Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000

Background We previously reported that the prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in Olmsted County, Minnesota, had risen significantly between 1940 and 1993. We sought to update the incidence and prevalence of these conditions in our region through 2000. Methods The Rochester Epidemiology Project allows population‐based studies of disease in county residents. CD and UC were defined by previously used criteria. County residents newly diagnosed between 1990 and 2000 were identified as incidence cases, and persons with these conditions alive and residing in the county on January 1, 2001, were identified as prevalence cases. All rates were adjusted to 2000 US Census figures for whites. Results In 1990–2000 the adjusted annual incidence rates for UC and CD were 8.8 cases per 100,000 (95% confidence interval [CI], 7.2–10.5) and 7.9 per 100,000 (95% CI, 6.3–9.5), respectively, not significantly different from rates observed in 1970–1979. On January 1, 2001, there were 220 residents with CD, for an adjusted prevalence of 174 per 100,000 (95% CI, 151–197), and 269 residents with UC, for an adjusted prevalence of 214 per 100,000 (95% CI, 188–240). Conclusion Although incidence rates of CD and UC increased after 1940, they have remained stable over the past 30 years. Since 1991 the prevalence of UC decreased by 7%, and the prevalence of CD increased about 31%. Extrapolating these figures to US Census data, there were ≈1.1 million people with inflammatory bowel disease in the US in 2000. (Inflamm Bowel Dis 2007)

[1]  A. Sonnenberg,et al.  Epidemiology of inflammatory bowel disease among U.S. military veterans. , 1991, Gastroenterology.

[2]  A Wajda,et al.  Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study. , 1999, American journal of epidemiology.

[3]  K. V. von Smitten,et al.  The incidence of Crohn's disease in the Helsinki metropolitan area during 1975-1985. , 1989, Annales chirurgiae et gynaecologiae.

[4]  D. Vicent,et al.  Incidence and prevalence of ulcerative colitis and Crohn's disease in urban and rural areas of Spain from 1981 to 1988. , 1994, Journal of clinical gastroenterology.

[5]  A. Thomson,et al.  Inflammatory bowel disease in northern Alberta. An epidemiologic study. , 1988, Journal of clinical gastroenterology.

[6]  J. Barton,et al.  Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983; marginal fall in ulcerative colitis, three-fold rise in Crohn's disease. , 1989, Gut.

[7]  A. Zinsmeister,et al.  Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. , 1998, Gastroenterology.

[8]  R. Newcombe,et al.  Incidence of ulcerative colitis in Cardiff over 20 years: 1968-87. , 1992, Gut.

[9]  R. Brummer,et al.  High incidence of inflammatory bowel disease in The Netherlands , 1998, Diseases of the colon and rectum.

[10]  R. Hiatt,et al.  Epidemiology of inflammatory bowel disease in a defined northern California population. , 1988, The Western journal of medicine.

[11]  L. Melton,et al.  History of the Rochester Epidemiology Project. , 1996, Mayo Clinic proceedings.

[12]  A. Zinsmeister,et al.  Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival , 2000, Gut.

[13]  W. Sandborn,et al.  Epidemiology of inflammatory bowel disease. , 2002, Gastroenterology clinics of North America.

[14]  C. Florén,et al.  Ulcerative colitis and indeterminate colitis in the city of Malmö, Sweden. A 25-year incidence study. , 1995, Scandinavian journal of gastroenterology.

[15]  G. Holmes,et al.  Crohn's disease in the city of Derby, 1951-85. , 1990, Gut.

[16]  H. Adami,et al.  The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. , 1991, Gastroenterology.

[17]  J. Lennard-jones,et al.  Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). , 1996, Gut.

[18]  E. Lindberg,et al.  The incidence of Crohn's disease is not decreasing in Sweden. , 1991, Scandinavian journal of gastroenterology.

[19]  J. Colombel,et al.  Incidence of inflammatory bowel disease in northern France (1988-1990). , 1994, Gut.

[20]  Anders Ekbom,et al.  Epidemiology of inflammatory bowel disease. , 1999, Nestle Nutrition workshop series. Clinical & performance programme.

[21]  F. Brahme,et al.  Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden. , 1975, Gastroenterology.

[22]  M. Vatn,et al.  Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. , 1996, Scandinavian journal of gastroenterology.

[23]  M. Tzardi,et al.  Ulcerative colitis is as common in Crete as in northern Europe: a 5-year prospective study. , 1996, European journal of gastroenterology & hepatology.

[24]  G. Järnerot,et al.  Ulcerative proctocolitis in Orebro, Sweden. A retrospective epidemiologic study, 1963-1987. , 1992, Scandinavian journal of gastroenterology.

[25]  G. Hellers,et al.  Incidence of ulcerative colitis in Stockholm County 1955-1979. , 1985, Scandinavian journal of gastroenterology.

[26]  R. Logan.  Inflammatory bowel disease incidence: up, down or unchanged? , 1998, Gut.

[27]  D. Palli,et al.  A population-based study of inflammatory bowel disease in Florence over 15 years (1978-92). , 1996, Scandinavian journal of gastroenterology.

[28]  G. Williams,et al.  Incidence of Crohn's disease in Cardiff over 60 years: 1986-1990 an update. , 1995, European journal of gastroenterology & hepatology.

[29]  L. Melton,et al.  Chronic ulcerative colitis: incidence and prevalence in a community. , 1987, Gut.

[30]  A. Lilienfeld,et al.  Trends in incidence rates of ulcerative colitis and Crohn's disease , 1984, Digestive Diseases and Sciences.

[31]  S. Kreiner,et al.  Incidence and prevalence of Crohn's disease in the county of Copenhagen, 1962-87: a sixfold increase in incidence. , 1992, Scandinavian journal of gastroenterology.

[32]  C. Probert,et al.  Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire. , 1992, Gut.

[33]  H. Drummond,et al.  Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland , 2001, European journal of gastroenterology & hepatology.

[34]  L. Elveback,et al.  Incidence of Crohn's disease in Olmsted County, Minnesota, 1935-1975. , 1980, American journal of epidemiology.

[35]  A. Sonnenberg,et al.  Geographic variation of inflammatory bowel disease within the United States. , 1991, Gastroenterology.

[36]  L. Kurland,et al.  Inflammatory colon disease in Rochester, Minnesota, 1935-1964. , 1972, Gastroenterology.

[37]  E. Oddsson,et al.  Inflammatory bowel disease in Iceland, 1980-89. A retrospective nationwide epidemiologic study. , 1998, Scandinavian journal of gastroenterology.

[38]  H T Sørensen,et al.  Change in incidence of Crohn's disease and ulcerative colitis in Denmark. A study based on the National Registry of Patients, 1981-1992. , 1997, International journal of epidemiology.

[39]  J. F. Fernández Rodriguez.  [Incidence of ulcerative colitis]. , 1972, Revista espanola de las enfermedades del aparato digestivo.

[40]  L. Melton,et al.  Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982. , 1988, Gut.

[41]  W. Chey,et al.  An epidemiologic study of inflammatory bowel disease in Rochester, New York. Hospital incidence. , 1990, Gastroenterology.

[42]  G. Corrao,et al.  Incidence of inflammatory bowel disease in Italy: a nationwide population-based study. Gruppo Italiano per lo Studio del Colon e del Retto (GISC) , 1996, International journal of epidemiology.

[43]  J. Kyle,et al.  Crohn's disease in the northeastern and northern Isles of Scotland: an epidemiological review. , 1992, Gastroenterology.

[44]  S. Kreiner,et al.  Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. , 1991, Scandinavian journal of gastroenterology.

[45]  R. Ahlquist,et al.  Increasing incidence of Crohn's disease. , 1983, American journal of surgery.

[46]  D. Chang,et al.  Incidence and prevalence of ulcerative colitis in the Songpa‐Kangdong District, Seoul, Korea, 1986–1997 , 2000 .