AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans.

Chicoric acid is a dicaffeoyl ester with many bioactivities, including antioxidation, antidiabetes, and anti-inflammation. A previous study reported that chicoric acid extended the lifespan in Caenorhabditis elegans; however, the mechanism behind the effect of chicoric acid on the extended lifespan remains unknown. Consistent with the previous report, chicoric acid (25 and 50 μM) extended the maximum lifespan compared to the control (17.5 ± 3.3 and 15.6 ± 5%, respectively; p < 0.001 for both). The declines of the pumping rate and locomotive activity, two indicators of aging, were delayed by chicoric acid. Moreover, chicoric acid enhanced resistance to oxidative stress in C. elegans. It was further determined that the extended lifespan by chicoric acid was in part via aak-2 [a homologue of adenosine monophosphate (AMP)-activated protein kinase] and skn-1 (a homologue of nuclear factor erythroid 2-related factor 2). The current findings suggest that chicoric acid has the potential to be used as an anti-aging bioactive compound.

[1]  p-Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans. , 2018, Journal of the science of food and agriculture.

[2]  D. Mcclements,et al.  Development of Functional or Medical Foods for Oral Administration of Insulin for Diabetes Treatment: Gastroprotective Edible Microgels. , 2018, Journal of agricultural and food chemistry.

[3]  Jolene Zheng,et al.  Caenorhabditis elegans: A Convenient In Vivo Model for Assessing the Impact of Food Bioactive Compounds on Obesity, Aging, and Alzheimer's Disease. , 2018, Annual review of food science and technology.

[4]  Seung-Jae V. Lee,et al.  Western Blot Analysis of C. elegans Proteins. , 2018, Methods in molecular biology.

[5]  H. Chang,et al.  Transcription factors CEP‐1/p53 and CEH‐23 collaborate with AAK‐2/AMPK to modulate longevity in Caenorhabditis elegans. , 2017, Aging cell.

[6]  Kee-Hong Kim,et al.  Piceatannol extends the lifespan of Caenorhabditis elegans via DAF‐16 , 2017, BioFactors.

[7]  Zhongwei Li,et al.  O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans , 2017, Scientific Reports.

[8]  Huai-Rong Luo,et al.  Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[9]  Yutang Wang,et al.  Pharmacokinetics, tissue distribution, and plasma protein binding study of chicoric acid by HPLC-MS/MS. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  P. Sangwan,et al.  Upregulation of Th1 Polarization by Taraxacum officinale in Normal and Immune Suppressed Mice , 2016 .

[11]  D. Mcclements,et al.  Delivery of dietary triglycerides to Caenorhabditis elegans using lipid nanoparticles: Nanoemulsion-based delivery systems. , 2016, Food chemistry.

[12]  Jeremy J. Yang,et al.  Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans. , 2016, Journal of medicinal food.

[13]  K. Carvajal,et al.  AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators , 2016, PloS one.

[14]  B. A. Akhoon,et al.  Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans , 2015, AGE.

[15]  Michael J. Steinbaugh,et al.  SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. , 2015, Free radical biology & medicine.

[16]  Nektarios Tavernarakis,et al.  Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans , 2015, Nature.

[17]  Nektarios Tavernarakis,et al.  20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Hyun-Jun Nam,et al.  Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans , 2014, Proceedings of the National Academy of Sciences.

[19]  T. Ishii,et al.  Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice. , 2014, Molecular nutrition & food research.

[20]  M. Driscoll,et al.  Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves. , 2014, Journal of agricultural and food chemistry.

[21]  C. Pan,et al.  Hydroxycinnamic acids in Crepidiastrum denticulatum protect oxidative stress-induced retinal damage. , 2014, Journal of agricultural and food chemistry.

[22]  F. Casas,et al.  Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans , 2013, PloS one.

[23]  E. Liebau,et al.  The Glutathione Reductase GSR-1 Determines Stress Tolerance and Longevity in Caenorhabditis elegans , 2013, PLoS ONE.

[24]  Linda Partridge,et al.  Ageing as a Risk Factor for Disease , 2012, Current Biology.

[25]  Stuart K. Kim,et al.  An Engineering Approach to Extending Lifespan in C. elegans , 2012, PLoS genetics.

[26]  A. Salminen,et al.  AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network , 2012, Ageing Research Reviews.

[27]  Hong Wu,et al.  Influence of several postharvest processing methods on polyphenol oxidase activity and cichoric acid content of Echinacea purpurea roots , 2011 .

[28]  G. Manning,et al.  Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB , 2011, Nature.

[29]  Kyung-Jin Min,et al.  Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. , 2010, Rejuvenation research.

[30]  W. Robinson,et al.  Design, synthesis, and biological evaluation of novel hybrid dicaffeoyltartaric/diketo acid and tetrazole-substituted L-chicoric acid analogue inhibitors of human immunodeficiency virus type 1 integrase. , 2010, Journal of medicinal chemistry.

[31]  J. Auwerx,et al.  AMP-activated protein kinase and its downstream transcriptional pathways , 2010, Cellular and Molecular Life Sciences.

[32]  G. Sykiotis,et al.  Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease , 2010, Science Signaling.

[33]  M. Driscoll,et al.  Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 , 2010, PloS one.

[34]  Jennifer M. A. Tullet,et al.  Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans , 2008, Cell.

[35]  Theresa Stiernagle.  Maintenance of C. elegans. , 2006, WormBook : the online review of C. elegans biology.

[36]  Kunihiro Matsumoto,et al.  Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[37]  J. Apfeld,et al.  The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. , 2004, Genes & development.

[38]  T. Blackwell,et al.  SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. , 2003, Genes & development.

[39]  N. Holbrook,et al.  Oxidants, oxidative stress and the biology of ageing , 2000, Nature.

[40]  B. Lakowski,et al.  The genetics of caloric restriction in Caenorhabditis elegans. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Koutarou D. Kimura,et al.  daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. , 1997, Science.

[42]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[43]  D. Harman.  Free‐Radical Theory of Aging , 1992, Mutation research.