Oxidative DNA damage is associated more with genome accessibility than spatial positioning in the nucleus

Reactive oxygen species (ROS) from cell metabolism and the exogenous environment cause macromolecule lesions, and they were implicated in many diseases (Ray, Huang, & Tsuji, 2012). ROS are oxygen c...

[1]  C. Burrows,et al.  Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq. , 2017, Journal of the American Chemical Society.

[2]  Eric Nestler,et al.  ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases , 2014, BMC Genomics.

[3]  Lilia M. Iakoucheva,et al.  Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation , 2012, Cell.

[4]  Fidel Ramírez,et al.  deepTools2: a next generation web server for deep-sequencing data analysis , 2016, Nucleic Acids Res..

[5]  Hong-yu Zhang,et al.  Oxidative DNA damage is important to the evolution of antibiotic resistance: evidence of mutation bias and its medicinal implications , 2013, Journal of biomolecular structure & dynamics.

[6]  B. Epe,et al.  Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions , 2010, Nucleic acids research.

[7]  Graphene oxide-methylene blue nanocomposite in photodynamic therapy of human breast cancer , 2018, Journal of biomolecular structure & dynamics.

[8]  A. Saboury,et al.  ROS-mediated heme degradation and cytotoxicity induced by iron nanoparticles: hemoglobin and lymphocyte cells as targets , 2018, Journal of biomolecular structure & dynamics.

[9]  M. Suyama,et al.  Genome-wide Profiling of 8-Oxoguanine Reveals Its Association with Spatial Positioning in Nucleus , 2014, DNA research : an international journal for rapid publication of reports on genes and genomes.

[10]  B. Steensel,et al.  Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells , 2015, EMBO reports.

[11]  A. Peters,et al.  Mechanisms of transcriptional repression by histone lysine methylation. , 2009, The International journal of developmental biology.

[12]  P. Flicek,et al.  Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. , 2010, Molecular cell.

[13]  P. Ray,et al.  Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. , 2012, Cellular signalling.

[14]  Enni Markkanen,et al.  Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. , 2010, DNA repair.