Vision enhancement systems

Abstract This chapter provides an overview of visual system properties in health and disease, with an emphasis on the stages in visual-signal processing that are most commonly affected by disease and dysfunction. It then provides an overview of current approaches to vision restoration and of approaches that promise to migrate from the lab to the clinic in the coming years. In a third section, the potential roles for engineered cells and tissues in this restoration process are discussed. The chapter closes with an estimate of the developments that can be expected to occur in the next 5–10 years.

[1]  James Weiland,et al.  Neural responses elicited by electrical stimulation of the retina. , 2006, Transactions of the American Ophthalmological Society.

[2]  R. H. Propst,et al.  Visual perception elicited by electrical stimulation of retina in blind humans. , 1996, Archives of ophthalmology.

[3]  H. Kaplan,et al.  Human photoreceptor transplantation in retinitis pigmentosa. A safety study. , 1997, Archives of ophthalmology.

[4]  I. Johnstone,et al.  Wavelet Threshold Estimators for Data with Correlated Noise , 1997 .

[5]  E. Zrenner,et al.  Compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs , 2007, Graefe's Archive for Clinical and Experimental Ophthalmology.

[6]  Adeno-associated virus-vectored gene therapy for retinal disease. , 2005 .

[7]  S. B. Brummer,et al.  Activated Ir: An Electrode Suitable for Reversible Charge Injection in Saline Solution , 1983 .

[8]  Lyndon J. Brown,et al.  Performance analysis of stationary and discrete wavelet transform for action potential detection from sympathetic nerve recordings in humans , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[9]  R Clay Reid,et al.  Demonstration of artificial visual percepts generated through thalamic microstimulation , 2007, Proceedings of the National Academy of Sciences.

[10]  Alex Villalobos,et al.  All-optical control of neuronal function via optical delivery of light-sensitive proteins and optogenetic stimulation , 2012, Photonics West - Biomedical Optics.

[11]  J S Sunness,et al.  Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. , 1999, Ophthalmology.

[12]  F. Musiek,et al.  Central Auditory Mechanisms Associated with Cochlear Implantation: An Overview of Selected Studies and Comment , 2010, Cochlear implants international.

[13]  M. Schwartz,et al.  Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation. , 2008, Progress in brain research.

[14]  Chethan Pandarinath,et al.  Retinal prosthetic strategy with the capacity to restore normal vision , 2012, Proceedings of the National Academy of Sciences.

[15]  M. Mladejovsky,et al.  Artificial Vision for the Blind: Electrical Stimulation of Visual Cortex Offers Hope for a Functional Prosthesis , 1974, Science.

[16]  R. Ali,et al.  Gene supplementation therapy for recessive forms of inherited retinal dystrophies , 2011, Gene Therapy.

[17]  W. H. Dobelle,et al.  Artificial vision for the blind by electrical stimulation of the visual cortex. , 1979, Neurosurgery.

[18]  D. Bok,et al.  Transplantation of retinal pigment epithelial cells and immune response in the subretinal space. , 1998, Investigative ophthalmology & visual science.

[19]  Bin Wang,et al.  Pegaptanib for the treatment of age-related macular degeneration. , 2006, Experimental eye research.

[20]  Ling Gu,et al.  Targeted microinjection into cells and retina using optoporation. , 2011, Journal of biomedical optics.

[21]  Gislin Dagnelie,et al.  Phosphene Mapping Procedures for Prosthetic Vision , 1999 .

[22]  Theodore Leng,et al.  A model retinal interface based on directed neuronal growth for single cell stimulation , 2006, Biomedical microdevices.

[23]  H. Kaplan,et al.  Harvest and storage of adult human retinal pigment epithelial sheets. , 1997, Current eye research.

[24]  P. Gouras,et al.  Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. , 1989, Investigative ophthalmology & visual science.

[25]  R. Aramant,et al.  Photoreceptor and glial markers in human embryonic retina and in human embryonic retinal transplants to rat retina. , 1994, Brain research. Developmental brain research.

[26]  P. Humphries,et al.  Gene-based therapies for dominantly inherited retinopathies , 2011, Gene Therapy.

[27]  J. R. Hughes,et al.  Brief, noninjurious electric waveform for stimulation of the brain. , 1955, Science.

[28]  Ling Gu,et al.  Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision , 2012 .

[29]  G. V. Wermeskerken,et al.  A comparison of intra- versus post-operatively acquired electrically evoked compound action potentials. , 2006 .

[30]  A. Milam,et al.  Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. , 1997, Archives of ophthalmology.

[31]  G Dagnelie,et al.  Human neural retinal transplantation. , 2000, Investigative ophthalmology & visual science.

[32]  K. Bartz-Schmidt,et al.  Transplantation of autologous iris pigment epithelium to the subretinal space in rabbits. , 1999, Transplantation.

[33]  Ida Lee,et al.  Platinization: a novel technique to anchor photosystem I reaction centres onto a metal surface at biological temperature and pH , 1996 .

[34]  P J Abbas,et al.  Using electrically evoked compound action potential thresholds to facilitate creating MAPs for children with the Nucleus CI24M. , 2000, Advances in oto-rhino-laryngology.

[35]  P. Gouras,et al.  Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization , 1994, Graefe's Archive for Clinical and Experimental Ophthalmology.

[36]  Gislin Dagnelie,et al.  Understanding the origin of visual percepts elicited by electrical stimulation of the human retina , 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

[37]  L. Benowitz,et al.  Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells , 2006, Nature Neuroscience.

[38]  I. Ahmad,et al.  Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat. , 2000, Biochemical and biophysical research communications.

[39]  J. Heckenlively,et al.  Clinical findings and common symptoms in retinitis pigmentosa. , 1988, American journal of ophthalmology.

[40]  Jean Delbeke,et al.  Measurement of evoked potentials after electrical stimulation of the human optic nerve. , 2010, Investigative ophthalmology & visual science.

[41]  B. Roska,et al.  Optogenetic therapy for retinitis pigmentosa , 2011, Gene Therapy.

[42]  M. Mladejovsky,et al.  ‘Braille’ reading by a blind volunteer by visual cortex stimulation , 1976, Nature.

[43]  T. Léveillard,et al.  Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. J. Warren,et al.  Functional reorganization of primary visual cortex induced by electrical stimulation in the cat , 2005, Vision Research.

[45]  N. Cohen,et al.  Cochlear Implants , 2019, The SAGE Encyclopedia of Human Communication Sciences and Disorders.

[46]  A. Y. Chow,et al.  Subretinal electrical stimulation of the rabbit retina , 1997, Neuroscience Letters.

[47]  W H Dobelle,et al.  Fabrication of large arrays of cortical electrodes for use in man. , 1977, Journal of biomedical materials research.

[48]  Fan-Gang Zeng,et al.  Auditory Prostheses: Past, Present, and Future , 2004 .

[49]  H. Kaplan,et al.  Retinal pigment epithelial transplantation in age-related macular degeneration. , 1998, Retina.

[50]  Lucas H M Mens,et al.  Advances in Cochlear Implant Telemetry: Evoked Neural Responses, Electrical Field Imaging, and Technical Integrity , 2007, Trends in amplification.

[51]  A. Adolph,et al.  Function and Structure in Retinal Transplants , 1994, Journal of neural transplantation & plasticity.

[52]  M. Zarbin,et al.  Preparation and transplantation of photoreceptor sheets , 1998 .

[53]  A. Aguayo,et al.  Growth and Connectivity of Axotomized Retinal Neurons in Adult Rats with Optic Nerves Substituted by PNS Grafts Linking the Eye and the Midbrain a , 1987, Annals of the New York Academy of Sciences.

[54]  R. Aramant,et al.  Donor age influences on the success of retinal grafts to adult rat retina. , 1988, Investigative ophthalmology & visual science.

[55]  R. Lund,et al.  Preservation of vision following cell-based therapies in a model of retinal degenerative disease , 2004, Vision Research.

[56]  Gislin Dagnelie,et al.  Electrically elicited visual evoked potentials in Argus II retinal implant wearers. , 2013, Investigative ophthalmology & visual science.

[57]  David J. Warren,et al.  Cortical implants for the blind , 1996 .

[58]  T. Velte,et al.  A computational model of electrical stimulation of the retinal ganglion cell , 1999, IEEE Transactions on Biomedical Engineering.

[59]  Stanley J. Wiegand,et al.  Intraretinal Transplantation for Rod-Cell Replacement in Light-Damaged Retinas , 1989, Journal of neural transplantation.

[60]  A. Milam,et al.  Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa. , 1999, Investigative ophthalmology & visual science.

[61]  M. Young,et al.  Stem cells in the mammalian eye: a tool for retinal repair , 2005, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[62]  K Heimann,et al.  Successful long-term implantation of electrically inactive epiretinal microelectrode arrays in rabbits. , 1999, Retina.

[63]  G. Dagnelie Retinal implants: emergence of a multidisciplinary field. , 2012, Current opinion in neurology.

[64]  W. Tao,et al.  Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device. , 2004, Tissue engineering.

[65]  L. S. Robblee,et al.  Assessment of capacitor electrodes for intracortical neural stimulation , 1985, Journal of Neuroscience Methods.

[66]  B. Hoefflinger,et al.  The development of subretinal microphotodiodes for replacement of degenerated photoreceptors. , 1997, Ophthalmic research.

[67]  Jean Bennett,et al.  Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[68]  J. Bennett,et al.  Development of Mitochondrial Gene Replacement Therapy , 2004, Journal of bioenergetics and biomembranes.

[69]  P. Campochiaro,et al.  Nonviral ocular gene transfer , 2005, Gene Therapy.

[70]  P. Gouras,et al.  Long-term photoreceptor transplants in dystrophic and normal mouse retina. , 1994, Investigative ophthalmology & visual science.

[71]  D Hickingbotham,et al.  Bipolar surface electrical stimulation of the vertebrate retina. , 1994, Archives of ophthalmology.

[72]  Philip Troyk,et al.  Looking ahead: planning for the first human intracortical visual prosthesis by using pilot data from focus groups of potential users , 2011, Disability and rehabilitation. Assistive technology.

[73]  F. Horak,et al.  Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. , 2011, Archives of neurology.

[74]  D.B. McCreery,et al.  Charge density and charge per phase as cofactors in neural injury induced by electrical stimulation , 1990, IEEE Transactions on Biomedical Engineering.

[75]  Peter Gouras,et al.  Retinal cell transplantation in the macula: New techniques , 1996, Vision Research.

[76]  Benoît Gérard,et al.  Pattern recognition with the optic nerve visual prosthesis. , 2003, Artificial organs.

[77]  Weng Tao,et al.  Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[78]  R. Lund,et al.  Transplantation of retinal pigment epithelial, photoreceptor and other cells as treatment for retinal degeneration. , 1997, Experimental eye research.

[79]  P. Rosenfeld,et al.  Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucentis) for neovascular age-related macular degeneration. , 2006, Ophthalmology.

[80]  M. Humayun,et al.  Allogenic fetal retinal pigment epithelial cell transplant in a patient with geographic atrophy. , 1999, Retina.

[81]  H Ueno,et al.  Retinal functional change caused by adenoviral vector-mediated transfection of LacZ gene. , 1998, Human gene therapy.

[82]  D. Beebe,et al.  Controlled microfluidic interfaces , 2005, Nature.

[83]  G. Fujii,et al.  Limited macular translocation , 2001, Eye.

[84]  J E Turner,et al.  Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation. , 1988, Experimental eye research.

[85]  P. Gouras,et al.  Survival and Synapse Formation of Transplanted Rat Rods , 1991, Journal of neural transplantation & plasticity.

[86]  Joseph F. Rizzo,et al.  Ocular implants for the blind , 1996 .

[87]  J. Weiland,et al.  Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. , 1999, Investigative ophthalmology & visual science.

[88]  R. Greenberg,et al.  An implantable neuro-stimulator device for a retinal prosthesis , 1999, 1999 IEEE International Solid-State Circuits Conference. Digest of Technical Papers. ISSCC. First Edition (Cat. No.99CH36278).

[89]  S. Ball,et al.  Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin , 1999, Vision Research.

[90]  A. Hodges,et al.  Update on cochlear implantation. , 1996, Otolaryngologic clinics of North America.

[91]  P. Gouras,et al.  Transplantation of RPE in age-related macular degeneration: Observations in disciform lesions and dry RPE atrophy , 1997, Graefe's Archive for Clinical and Experimental Ophthalmology.

[92]  S. Seregard,et al.  Long-term outcome of RPE allografts to the subretinal space of rabbits. , 1999, Acta ophthalmologica Scandinavica.

[93]  E. Maynard,et al.  A technique to prevent dural adhesions to chronically implanted microelectrode arrays , 2000, Journal of Neuroscience Methods.

[94]  M. Silverman,et al.  Photoreceptor transplants increase host cone survival in the retinal degeneration (rd) mouse. , 1997, Ophthalmic research.

[95]  O. Mimura,et al.  Apoptotic Death of β Cells after Optic Nerve Transection in Adult Cats , 2003, The Journal of Neuroscience.

[96]  H. M. Petry,et al.  Preliminary report: indications of improved visual function after retinal sheet transplantation in retinitis pigmentosa patients. , 1999, American journal of ophthalmology.

[97]  Carolyn J. Brown,et al.  Relationships Between Electrically Evoked Potentials and Loudness Growth in Bilateral Cochlear Implant Users , 2012, Ear and hearing.

[98]  Jessy D. Dorn,et al.  The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis. , 2013, JAMA ophthalmology.

[99]  S. Thanos,et al.  Neurobiology of the regenerating retina and its functional reconnection with the brain by means of peripheral nerve transplants in adult rats. , 1997, Survey of ophthalmology.

[100]  B. Jones,et al.  Effect of shape and coating of a subretinal prosthesis on its integration with the retina. , 2009, Experimental eye research.

[101]  W. Reichert,et al.  Polyimides as biomaterials: preliminary biocompatibility testing. , 1993, Biomaterials.

[102]  M. Humayun,et al.  Histologic correlation of human neural retinal transplantation. , 2000, Investigative ophthalmology & visual science.

[103]  Y. Fukuda,et al.  Functional recovery of vision in regenerated optic nerve fibers , 1998, Vision Research.

[104]  R. Hornig,et al.  Clinical stability of a new method for fixation and explanation of epiretinal implants , 2010, Acta ophthalmologica.

[105]  R. Aramant,et al.  Intact sheets of fetal retina transplanted to restore damaged rat retinas. , 1998, Investigative ophthalmology & visual science.

[106]  R. L. Green,et al.  INTRAVITREAL BIOCOMPATIBILITY OF MUSSEL ADHESIVE PROTEIN: A Preliminary Study , 1990, Retina.

[107]  Wentai Liu,et al.  Retinal Prosthesis , 2018, Essentials in Ophthalmology.

[108]  T. Léveillard,et al.  Inherited retinal degenerations: therapeutic prospects. , 2004, Biology of the cell.

[109]  H. Quigley,et al.  Stem cells to replace the optic nerve , 2004, Eye.

[110]  Guido F. Smoorenburg,et al.  Speech Perception in Nucleus CI24M Cochlear Implant Users with Processor Settings Based on Electrically Evoked Compound Action Potential Thresholds , 2002, Audiology and Neurotology.

[111]  Malini Narayanan Nadig Development of a silicon retinal implant: cortical evoked potentials following focal stimulation of the rabbit retina with light and electricity , 1999, Clinical Neurophysiology.

[112]  C. Kufta,et al.  Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. , 1996, Brain : a journal of neurology.

[113]  M. Cerro,et al.  The Transplantation of Human Fetal Neuroretinal Cells in Advanced Retinitis Pigmentosa Patients: Results of a Long-Term Safety Study , 1999, Experimental Neurology.

[114]  H. Sawai,et al.  Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Stimulate Growth of Axonal Branches from Regenerating Retinal Ganglion Cells , 1996, The Journal of Neuroscience.

[115]  K. Bartz-Schmidt,et al.  Descemet's membrane as membranous support in RPE/IPE transplantation. , 1997, Current eye research.

[116]  E. Bamberg,et al.  Channelrhodopsin-2, a directly light-gated cation-selective membrane channel , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[117]  G. Loeb,et al.  Visual sensations produced by intracortical microstimulation of the human occipital cortex , 1990, Medical and Biological Engineering and Computing.

[118]  S. B. Brummer,et al.  Electrical stimulation of the nervous system: The principle of safe charge injection with noble metal electrodes , 1975 .

[119]  Gislin Dagnelie,et al.  Visual perception in a blind subject with a chronic microelectronic retinal prosthesis , 2003, Vision Research.

[120]  J E Turner,et al.  Newborn rat retinal cells transplanted into a retinal lesion site in adult host eyes. , 1986, Brain research.

[121]  B. Ehinger,et al.  Partial and full-thickness neuroretinal transplants. , 1999, Experimental eye research.

[122]  A. Ho,et al.  Stem cell therapy for retinal disease , 2012, Current opinion in ophthalmology.

[123]  J. Mortimer,et al.  Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode , 1998, Brain Research.

[124]  M. Lavail,et al.  Protection of mouse photoreceptors by survival factors in retinal degenerations. , 1998, Investigative ophthalmology & visual science.

[125]  L. Levin Neuroprotection and regeneration in glaucoma. , 2005, Ophthalmology clinics of North America.

[126]  B. Schobert,et al.  Halorhodopsin is a light-driven chloride pump. , 1982, The Journal of biological chemistry.

[127]  Robert Lanza,et al.  Long‐Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration , 2009, Stem cells.

[128]  Artur V. Cideciyan,et al.  Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy , 2010, Progress in Retinal and Eye Research.

[129]  S. Kelly,et al.  Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. , 2003, Investigative ophthalmology & visual science.

[130]  S. Kochanek,et al.  Autologous transplantation of genetically modified iris pigment epithelial cells: A promising concept for the treatment of age-related macular degeneration and other disorders of the eye , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[131]  R D Ross,et al.  Is perception of light useful to the blind patient? , 1998, Archives of ophthalmology.

[132]  J. Ison,et al.  Intraretinal grafting restores visual function in light-blinded rats. , 1991, Neuroreport.

[133]  Alfred Stett,et al.  Subretinal electronic chips allow blind patients to read letters and combine them to words , 2010, Proceedings of the Royal Society B: Biological Sciences.

[134]  Jean Bennett,et al.  Gene therapy restores vision in a canine model of childhood blindness , 2001, Nature Genetics.

[135]  S. D'Anna,et al.  Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats. , 1997, Investigative ophthalmology & visual science.

[136]  Douglas S Kim,et al.  Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration , 2008, Nature Neuroscience.

[137]  M. Strube,et al.  Relation of Electrically Evoked Compound Action Potential Thresholds to Behavioral T- and C-Levels in Children with Cochlear Implants , 2009, Ear and hearing.

[138]  Thomas Laube,et al.  A method and technical equipment for an acute human trial to evaluate retinal implant technology , 2005, Journal of neural engineering.

[139]  M. Elman,et al.  Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. , 2003, Transactions of the American Ophthalmological Society.

[140]  R. Lund,et al.  Reinnervation of the pretectum in adult rats by regenerated retinal ganglion cell axons: anatomical and functional studies. , 2002, Progress in brain research.

[141]  E Peli,et al.  Image enhancement for the visually impaired: the effects of enhancement on face recognition. , 1994, Journal of the Optical Society of America. A, Optics, image science, and vision.

[142]  J. Weiland,et al.  Pattern electrical stimulation of the human retina , 1999, Vision Research.

[143]  B. Carter,et al.  Adeno-associated virus vectors in clinical trials. , 2005, Human gene therapy.

[144]  R. Aramant,et al.  Transplantation of Neuroblastic Progenitor Cells as a Sheet Preserves and Restores Retinal Function , 2005, Seminars in ophthalmology.

[145]  R. Quian Quiroga,et al.  Single-trial event-related potentials with wavelet denoising , 2003, Clinical Neurophysiology.

[146]  P. Gouras,et al.  Long-Term Outcome of RPE Allografts in Non-Immunosuppressed Patients with AMD , 1999, European journal of ophthalmology.

[147]  W. H. Dobelle Artificial vision for the blind by connecting a television camera to the visual cortex. , 2000, ASAIO journal.

[148]  W. Hauswirth,et al.  Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[149]  M. Verp,et al.  Growth of human fetal retinal pigment epithelium as microspheres , 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

[150]  A. Sher,et al.  Photovoltaic Retinal Prosthesis with High Pixel Density , 2012, Nature Photonics.

[151]  Y. Fukuda,et al.  Survival and axonal regeneration of retinal ganglion cells in adult cats , 2002, Progress in Retinal and Eye Research.

[152]  Daniel Palanker,et al.  Migration of retinal cells through a perforated membrane: implications for a high-resolution prosthesis. , 2004, Investigative ophthalmology & visual science.

[153]  M. Elman,et al.  Thrombolytic therapy for central retinal vein occlusion: results of a pilot study. , 1997, Transactions of the American Ophthalmological Society.

[154]  D. Edell,et al.  Factors influencing the biocompatibility of insertable silicon microshafts in cerebral cortex , 1992, IEEE Transactions on Biomedical Engineering.

[155]  Feng Zhang,et al.  Multimodal fast optical interrogation of neural circuitry , 2007, Nature.

[156]  S. Wiegand,et al.  Intraocular retinal transplants. , 1985, Investigative ophthalmology & visual science.

[157]  J. Goldberg,et al.  Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement. , 2012, Ophthalmology.

[158]  Ida Lee,et al.  Biomolecular Electronics: Vectorial Arrays of Photosynthetic Reaction Centers , 1997 .

[159]  R. Eckmiller Learning retina implants with epiretinal contacts. , 1997, Ophthalmic research.

[160]  Manuel del Cerro,et al.  Water escape performance of adult RCS dystrophic and congenic rats: a functional and histomorphometric study , 1996, Brain Research.

[161]  K. Deisseroth,et al.  eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications , 2008, Brain cell biology.

[162]  Terence R Flotte,et al.  Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study. , 2003, Human gene therapy.

[163]  Q. Ren,et al.  Mechanical Analysis and Fabrication of a Penetrating Silicon Microprobe as an Artificial Optic Nerve Visual Prosthesis , 2012, The International journal of artificial organs.

[164]  J. T. Ernest,et al.  A new model of retinal pigment epithelium transplantation with microspheres. , 1999, Archives of ophthalmology.

[165]  G. Brindley,et al.  The sensations produced by electrical stimulation of the visual cortex , 1968, The Journal of physiology.

[166]  D. B. Clarke,et al.  Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats , 1998, Vision Research.

[167]  Edward S Boyden,et al.  Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[168]  B. Jones,et al.  Retinal remodeling during retinal degeneration. , 2005, Experimental eye research.

[169]  C. Kufta,et al.  Visuotopic mapping through a multichannel stimulating implant in primate V1. , 2005, Journal of neurophysiology.

[170]  Richard A. Normann,et al.  Simulation of a phosphene-based visual field: Visual acuity in a pixelized vision system , 2006, Annals of Biomedical Engineering.

[171]  W. Hauswirth,et al.  Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa. , 1998, Investigative ophthalmology & visual science.

[172]  A. Y. Chow,et al.  The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. , 2004, Archives of ophthalmology.

[173]  M. Humayun,et al.  Molecular photovoltaics and the photoactivation of mammalian cells , 2005, IEEE Transactions on NanoBioscience.

[174]  Jessy D. Dorn,et al.  The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss , 2013, British Journal of Ophthalmology.

[175]  James D. Weiland,et al.  Bioadhesives for intraocular use. , 2000 .

[176]  S. E. Hughes,et al.  Transplantation of photoreceptors to light-damaged retina. , 1989, Investigative ophthalmology & visual science.

[177]  W. Inhoffen,et al.  In vivo assessment of subretinally implanted microphotodiode arrays in cats by optical coherence tomography and fluorescein angiography , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[178]  Mari Dezawa,et al.  Role of Schwann cells in retinal ganglion cell axon regeneration , 2000, Progress in Retinal and Eye Research.

[179]  K. Horch,et al.  Mobility performance with a pixelized vision system , 1992, Vision Research.

[180]  G. Dagnelie,et al.  Toward an artificial eye , 1996 .

[181]  F. Gage,et al.  Widespread Integration and Survival of Adult-Derived Neural Progenitor Cells in the Developing Optic Retina , 1998, Molecular and Cellular Neuroscience.

[182]  W. Hauswirth,et al.  Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa , 1998, Nature Medicine.

[183]  Karsten König,et al.  Cell biology: Targeted transfection by femtosecond laser , 2002, Nature.

[184]  A. Dizhoor,et al.  Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration , 2006, Neuron.

[185]  Matthijs Killian,et al.  AutoNRTTM: An automated system that measures ECAP thresholds with the Nucleus® FreedomTM cochlear implant via machine intelligence , 2007, Artif. Intell. Medicine.

[186]  Wentai Liu,et al.  Architecture Tradeoffs in High Density Microstimulators for Retinal Prosthesis , 2005, Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005..

[187]  Karl Deisseroth,et al.  Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa , 2010, Science.

[188]  Paul J. Abbas,et al.  The clinical application of potentials evoked from the peripheral auditory system , 2008, Hearing Research.

[189]  Gislin Dagnelie,et al.  Visual prosthetics 2006: assessment and expectations , 2006 .

[190]  Jessy D. Dorn,et al.  Blind subjects implanted with the Argus II retinal prosthesis are able to improve performance in a spatial-motor task , 2010, British Journal of Ophthalmology.

[191]  M. D. del Cerro,et al.  The first decade of continuous progress in retinal transplantation , 1997, Microscopy research and technique.

[192]  Peter Gouras,et al.  Retroviral gene transfer into retinal pigment epithelial cells followed by transplantation into rat retina. , 1995 .

[193]  E. Boyden,et al.  Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution , 2007, PloS one.

[194]  W. Dobelle,et al.  Phosphenes produced by electrical stimulation of human occipital cortex, and their application to the development of a prosthesis for the blind , 1974, The Journal of physiology.

[195]  B. Roska,et al.  Gene therapy in ophthalmology: validation on cultured retinal cells and explants from postmortem human eyes. , 2011, Human gene therapy.

[196]  P. Gouras,et al.  Transplantation of cultured human retinal epithelium to Bruch's membrane of the owl monkey's eye. , 1985, Current eye research.

[197]  D. van der Kooy,et al.  Retinal stem cells in the adult mammalian eye. , 2000, Science.

[198]  D. J. Warren,et al.  A neural interface for a cortical vision prosthesis , 1999, Vision Research.

[199]  Gislin Dagnelie,et al.  Psychophysical evaluation for visual prosthesis. , 2008, Annual review of biomedical engineering.

[200]  G. Peyman,et al.  A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring. , 1991, Ophthalmic surgery.

[201]  G. Feng,et al.  Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits , 2006, The Journal of Neuroscience.

[202]  R. Masland,et al.  Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin , 2008, Proceedings of the National Academy of Sciences.

[203]  K W Horch,et al.  Reading speed with a pixelized vision system. , 1992, Journal of the Optical Society of America. A, Optics and image science.

[204]  S. Seregard,et al.  Cyclosporine treatment of RPE allografts in the rabbit subretinal space. , 2000, Acta ophthalmologica Scandinavica.