Distinct features of fast oscillations in phasic and tonic rapid eye movement sleep

Spatiotemporal activity patterns of neurones are organized by different types of coherent network oscillations. Frequency content and cross‐frequency coupling of cortical oscillations are strongly state‐dependent, indicating that different patterns of wakefulness or sleep, respectively, support different cognitive or mnestic processes. It is therefore crucial to analyse specific sleep patterns with respect to their oscillations, including interaction between fast and slow rhythms. Here we report the oscillation profile of phasic rapid eye movement (REM), a form of REM sleep which has been implicated in hippocampus‐dependent memory processing. In all analysed frequency bands (theta, gamma and fast gamma, respectively) we find higher frequencies and higher power in phasic REM compared to tonic REM or wakefulness. Theta‐phase coupling of fast oscillations, however, was highest in tonic REM, followed by phasic REM and wakefulness. Our data suggest different roles of phasic and tonic REM for information processing or memory formation during sleep.

[1]  Adriano B L Tort,et al.  Theta phase modulates multiple layer-specific oscillations in the CA1 region. , 2012, Cerebral cortex.

[2]  Nikolai Axmacher,et al.  Memory processes during sleep: beyond the standard consolidation theory , 2009, Cellular and Molecular Life Sciences.

[3]  Jan Born,et al.  Slow oscillations orchestrating fast oscillations and memory consolidation. , 2011, Progress in brain research.

[4]  N. Katayama,et al.  Instantaneous acceleration and amplification of hippocampal theta wave coincident with phasic pontine activities during REM sleep , 2005, Brain Research.

[5]  Alexei L. Vyssotski,et al.  EEG gamma frequency and sleep–wake scoring in mice: Comparing two types of supervised classifiers , 2010, Brain Research.

[6]  R. Knight,et al.  The functional role of cross-frequency coupling , 2010, Trends in Cognitive Sciences.

[7]  S. Datta,et al.  Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity , 2004, The Journal of Neuroscience.

[8]  C. H. Vanderwolf,et al.  Two types of cerebral activation during active sleep: relations to behavior , 1977, Brain Research.

[9]  Adriano B. L. Tort,et al.  Theta–gamma coupling increases during the learning of item–context associations , 2009, Proceedings of the National Academy of Sciences.

[10]  Sean M Montgomery,et al.  Theta and Gamma Coordination of Hippocampal Networks during Waking and Rapid Eye Movement Sleep , 2008, The Journal of Neuroscience.

[11]  G. Buzsáki,et al.  Hippocampal CA1 pyramidal cells form functionally distinct sublayers , 2011, Nature Neuroscience.

[12]  G. Buzsáki,et al.  Neuronal Oscillations in Cortical Networks , 2004, Science.

[13]  Alexei L. Vyssotski,et al.  Selective Coupling between Theta Phase and Neocortical Fast Gamma Oscillations during REM-Sleep in Mice , 2011, PloS one.

[14]  H. Eichenbaum,et al.  Measuring phase-amplitude coupling between neuronal oscillations of different frequencies. , 2010, Journal of neurophysiology.

[15]  G. Buzsáki,et al.  A neural coding scheme formed by the combined function of gamma and theta oscillations. , 2008, Schizophrenia bulletin.