Targeting MicroRNAs in Prevention and Treatment of Neurodegenerative Disorders

Preclinical Research

[1]  Preetam Ghosh,et al.  DISMIRA: Prioritization of disease candidates in miRNA-disease associations based on maximum weighted matching inference model and motif-based analysis , 2015, BMC Genomics.

[2]  Xiuping Liu,et al.  FOXP3-miR-146-NF-κB Axis and Therapy for Precancerous Lesions in Prostate. , 2015, Cancer research.

[3]  Yan Zhang,et al.  Three-dimensional regulation of transcription , 2015, Protein & Cell.

[4]  D. Houitte,et al.  The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases , 2015, The Journal of Neuroscience.

[5]  N. Berman,et al.  Differential response of miRNA-21 and its targets after traumatic brain injury in aging mice , 2014, Neurochemistry International.

[6]  W. Lukiw,et al.  Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS , 2014, Front. Neurol..

[7]  Y. Torrente,et al.  The involvement of microRNAs in neurodegenerative diseases , 2013, Front. Cell. Neurosci..

[8]  T. Möller,et al.  Presenilin 2 influences miR146 level and activity in microglia , 2013, Journal of neurochemistry.

[9]  E. Goodall,et al.  Neuronal dark matter: the emerging role of microRNAs in neurodegeneration , 2013, Front. Cell. Neurosci..

[10]  Anna M. Krichevsky,et al.  MiR-26b, Upregulated in Alzheimer's Disease, Activates Cell Cycle Entry, Tau-Phosphorylation, and Apoptosis in Postmitotic Neurons , 2013, The Journal of Neuroscience.

[11]  H. Ye,et al.  MicroRNA-98 induces an Alzheimer’s disease-like disturbance by targeting insulin-like growth factor 1 , 2013, Neuroscience Bulletin.

[12]  Hong Zhou,et al.  miR‐21 modulates the ERK–MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation , 2013, Journal of cellular biochemistry.

[13]  K. Sliwa,et al.  MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. , 2013, The Journal of clinical investigation.

[14]  H. Ohta,et al.  Roles of FGF20 in dopaminergic neurons and Parkinson's disease , 2013, Front. Mol. Neurosci..

[15]  J. Obeso,et al.  Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease , 2013, Cell Death and Disease.

[16]  Ping He,et al.  MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. , 2013, Human molecular genetics.

[17]  Z. Hong,et al.  miR‐21 represses FasL in microglia and protects against microglia‐mediated neuronal cell death following hypoxia/ischemia , 2012, Glia.

[18]  Hui Zhou,et al.  ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data , 2012, Nucleic Acids Res..

[19]  Wojciech J. Szlachcic,et al.  Mouse Models of Polyglutamine Diseases in Therapeutic Approaches: Review and Data Table. Part II , 2012, Molecular Neurobiology.

[20]  B. Ray,et al.  MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients* , 2012, The Journal of Biological Chemistry.

[21]  F. Coppedè,et al.  Genetics and Epigenetics of Parkinson's Disease , 2012, TheScientificWorldJournal.

[22]  J. Stenvang,et al.  The Therapeutic Potential of MicroRNAs in Cancer , 2012, Cancer journal.

[23]  Gang Wang,et al.  The potential role of microRNA-146 in Alzheimer's disease: biomarker or therapeutic target? , 2012, Medical hypotheses.

[24]  E. Olson,et al.  Inhibition of miR-15 Protects Against Cardiac Ischemic Injury , 2012, Circulation research.

[25]  W. Lukiw,et al.  Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome , 2011, Journal of toxicology and environmental health. Part A.

[26]  B. Hyman,et al.  Neuropathological alterations in Alzheimer disease. , 2011, Cold Spring Harbor perspectives in medicine.

[27]  James B. Uney,et al.  Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons , 2011, PloS one.

[28]  Danish Sayed,et al.  MicroRNAs in development and disease. , 2011, Physiological reviews.

[29]  P. Wong,et al.  Amyloid precursor protein processing and Alzheimer's disease. , 2011, Annual review of neuroscience.

[30]  Xavier Estivill,et al.  MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. , 2011, Human molecular genetics.

[31]  G. Hirokawa,et al.  Plasma miR-124 as a biomarker for cerebral infarction. , 2011, Biomedical research.

[32]  D. Rubinsztein,et al.  The Parkinson disease protein α-synuclein inhibits autophagy , 2011, Autophagy.

[33]  E. Olson,et al.  Transient Regenerative Potential of the Neonatal Mouse Heart , 2011, Science.

[34]  K. Kelnar,et al.  The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. , 2011, Nature medicine.

[35]  Peter T. Nelson,et al.  Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter , 2011, Acta Neuropathologica.

[36]  Huaxi Xu,et al.  APP processing in Alzheimer's disease , 2011, Molecular Brain.

[37]  S. Hébert,et al.  In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs , 2011, Journal of neurochemistry.

[38]  M. Skalej,et al.  Gliomas in adults. , 2010, Deutsches Arzteblatt international.

[39]  Luc Buée,et al.  Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. , 2010, Human molecular genetics.

[40]  Yuhai Zhao,et al.  Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease* , 2010, The Journal of Biological Chemistry.

[41]  K. Kelnar,et al.  Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. , 2010, Cancer research.

[42]  Guanghai Yang,et al.  MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). , 2010, Clinica chimica acta; international journal of clinical chemistry.

[43]  C. Barbato,et al.  MicroRNA-101 Regulates Amyloid Precursor Protein Expression in Hippocampal Neurons* , 2010, The Journal of Biological Chemistry.

[44]  James B Leverenz,et al.  Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2. , 2010, Brain : a journal of neurology.

[45]  Beat Meier,et al.  Prions , 2010 .

[46]  Juan Nunez-Iglesias,et al.  Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation , 2010, PloS one.

[47]  Epaminondas Doxakis,et al.  Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153 , 2010, The Journal of Biological Chemistry.

[48]  Yuhai Zhao,et al.  Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. , 2009, Journal of inorganic biochemistry.

[49]  Zhenghe Wang,et al.  microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. , 2009, Cancer research.

[50]  R. Nussbaum,et al.  A single nucleotide polymorphism in the 3′UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease , 2009, Neuroscience Letters.

[51]  Rossen Donev,et al.  Neuronal death in Alzheimer’s disease and therapeutic opportunities , 2009, Journal of cellular and molecular medicine.

[52]  Brian D Athey,et al.  New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites. , 2009, Genome research.

[53]  Reuven Agami,et al.  The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. , 2009, Genes & development.

[54]  J. Hardy,et al.  The genetics of Parkinson's syndromes: a critical review. , 2009, Current opinion in genetics & development.

[55]  Rory Johnson,et al.  Gene Dysregulation in Huntington’s Disease: REST, MicroRNAs and Beyond , 2009, NeuroMolecular Medicine.

[56]  S. Hébert,et al.  Alterations of the microRNA network cause neurodegenerative disease , 2009, Trends in Neurosciences.

[57]  Bo Zhang,et al.  Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells , 2009, BMC Molecular Biology.

[58]  D. Bartel.  MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[59]  Wei Liu,et al.  MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. , 2008, Cancer letters.

[60]  Walter J. Lukiw,et al.  An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells* , 2008, Journal of Biological Chemistry.

[61]  S. Booth,et al.  A miRNA Signature of Prion Induced Neurodegeneration , 2008, PloS one.

[62]  Mauro Biffoni,et al.  The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities , 2008, Nature Medicine.

[63]  Eric T. Wang,et al.  Alternative Isoform Regulation in Human Tissue Transcriptomes , 2008, Nature.

[64]  Alice Shapiro,et al.  MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. , 2008, Cancer research.

[65]  R. Shiekhattar,et al.  Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies , 2008, Proceedings of the National Academy of Sciences.

[66]  Yunqing Li,et al.  microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. , 2008, Cancer research.

[67]  F. Slack,et al.  The let-7 microRNA reduces tumor growth in mouse models of lung cancer , 2008, Cell cycle.

[68]  K. Morris,et al.  RNA and transcriptional modulation of gene expression , 2008, Cell cycle.

[69]  Elena Cattaneo,et al.  A microRNA-based gene dysregulation pathway in Huntington's disease , 2008, Neurobiology of Disease.

[70]  G. Meister,et al.  The Argonaute protein family , 2008, Genome Biology.

[71]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[72]  Stijn van Dongen,et al.  miRBase: tools for microRNA genomics , 2007, Nucleic Acids Res..

[73]  G. Hannon,et al.  A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons , 2007, Science.

[74]  Sunit K. Singh.  miRNAs: from neurogeneration to neurodegeneration. , 2007, Pharmacogenomics.

[75]  F. Slack,et al.  The let-7 microRNA represses cell proliferation pathways in human cells. , 2007, Cancer research.

[76]  K. Ghoshal,et al.  MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. , 2007, Gastroenterology.

[77]  William Stafford Noble,et al.  Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project , 2007, Nature.

[78]  Xiaoxia Qi,et al.  Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA , 2007, Science.

[79]  A. Basu,et al.  Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis , 2007, Glia.

[80]  M. Farrer,et al.  Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication , 2007, Neurology.

[81]  Weiyun Zhu,et al.  Impact of tiny miRNAs on cancers. , 2007, World journal of gastroenterology.

[82]  K. Kosik.  The neuronal microRNA system , 2006, Nature Reviews Neuroscience.

[83]  Nikolaus Rajewsky,et al.  L(ou)sy miRNA targets? , 2006, Nature Structural &Molecular Biology.

[84]  D. Baltimore,et al.  NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses , 2006, Proceedings of the National Academy of Sciences.

[85]  A. Brice,et al.  A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling , 2006, Nature Cell Biology.

[86]  Helen Pearson.  Genetics: What is a gene? , 2006, Nature.

[87]  Stijn van Dongen,et al.  miRBase: microRNA sequences, targets and gene nomenclature , 2005, Nucleic Acids Res..

[88]  R. Plasterk,et al.  RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. , 2005, RNA.

[89]  S. Hammond.  Dicing and slicing , 2005, FEBS letters.

[90]  Kenneth S. Kosik,et al.  The Elegance of the MicroRNAs: A Neuronal Perspective , 2005, Neuron.

[91]  W. Lukiw,et al.  Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture. , 2005, Journal of inorganic biochemistry.

[92]  K. Kosik,et al.  MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. , 2005, Cancer research.

[93]  Haipeng Cheng,et al.  Spatial Segregation of γ-Secretase and Substrates in Distinct Membrane Domains* , 2005, Journal of Biological Chemistry.

[94]  A. Hüttenhofer,et al.  Non-coding RNAs: hope or hype? , 2005, Trends in genetics : TIG.

[95]  F. Slack,et al.  RAS Is Regulated by the let-7 MicroRNA Family , 2005, Cell.

[96]  Nicholas W Wood,et al.  A common LRRK2 mutation in idiopathic Parkinson's disease , 2005, The Lancet.

[97]  B. Cullen.  Transcription and processing of human microRNA precursors. , 2004, Molecular cell.

[98]  Sanghyuk Lee,et al.  MicroRNA genes are transcribed by RNA polymerase II , 2004, The EMBO journal.

[99]  V. Ambros.  The functions of animal microRNAs , 2004, Nature.

[100]  J. Cui,et al.  Cyclooxygenase-3 Gene Expression in Alzheimer Hippocampus and in Stressed Human Neural Cells , 2004, Neurochemical Research.

[101]  Pasko Rakic,et al.  Microarray analysis of microRNA expression in the developing mammalian brain , 2004, Genome Biology.

[102]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature Reviews Genetics.

[103]  R. Nussbaum,et al.  Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 , 2004, Science.

[104]  David W. Miller,et al.  L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System* , 2003, Journal of Biological Chemistry.

[105]  Andrea Crotti,et al.  Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes , 2003, Nature Genetics.

[106]  R. Ravid,et al.  Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639 , 2003, The European journal of neuroscience.

[107]  Bin Liu,et al.  Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention , 2003, Journal of Pharmacology and Experimental Therapeutics.

[108]  C. Croce,et al.  Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[109]  T. Tuschl,et al.  Identification of Novel Genes Coding for Small Expressed RNAs , 2001, Science.

[110]  Elena Cattaneo,et al.  Loss of normal huntingtin function: new developments in Huntington's disease research , 2001, Trends in Neurosciences.

[111]  Shinsei Minoshima,et al.  Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase , 2000, Nature Genetics.

[112]  G P Bates,et al.  Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[113]  M. Citron,et al.  Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation* , 1999, The Journal of Biological Chemistry.

[114]  Stanley B. Prusiner,et al.  Nobel Lecture: Prions , 1998 .

[115]  Nigel J. Cairns,et al.  Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies , 1998, Neuroscience Letters.

[116]  A. Giese,et al.  Role of Microglia in Neuronal Cell Death in Prion Disease , 1998, Brain pathology.

[117]  P. Lansbury,et al.  A detergent-insoluble membrance compartment contains Aβ in vivo , 1998, Nature Medicine.

[118]  M. Polymeropoulos,et al.  Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23 , 1996, Science.

[119]  H. Braak,et al.  Evolution of the neuropathology of Alzheimer's disease , 1996, Acta neurologica Scandinavica. Supplementum.

[120]  L. Mucke,et al.  Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease (*) , 1995, The Journal of Biological Chemistry.

[121]  M. Vitek,et al.  Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis , 1991, Neurobiology of Aging.

[122]  J. Bamford,et al.  Classification and natural history of clinically identifiable subtypes of cerebral infarction , 1991, The Lancet.

[123]  R. Neve,et al.  The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain , 1990, Neuron.

[124]  S. Younkin,et al.  Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR , 1990, Neuron.

[125]  O. Hobert,et al.  Diverse functions of microRNAs in nervous system development. , 2012, Current topics in developmental biology.

[126]  B. de Strooper,et al.  Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. , 2012, Cold Spring Harbor perspectives in medicine.

[127]  S. Khoo,et al.  Plasma-based circulating MicroRNA biomarkers for Parkinson's disease. , 2012, Journal of Parkinson's disease.

[128]  G. Schratt,et al.  MicroRNA function in the nervous system. , 2011, Progress in molecular biology and translational science.

[129]  Sam Griffiths-Jones,et al.  miRBase: the microRNA sequence database. , 2006, Methods in molecular biology.

[130]  J. Caboche,et al.  [Role of dopamine in Huntington's disease]. , 2006, Medecine sciences : M/S.

[131]  R. Tanzi,et al.  Genetic heterogeneity of gene defects responsible for familial Alzheimer disease , 2005, Genetica.

[132]  Haipeng Cheng,et al.  Spatial segregation of gamma-secretase and substrates in distinct membrane domains. , 2005, The Journal of biological chemistry.

[133]  Ronald W Davis,et al.  A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. , 2004, Developmental cell.

[134]  Sam Griffiths-Jones,et al.  The microRNA Registry , 2004, Nucleic Acids Res..

[135]  N. Dhalla,et al.  Pathogenesis of atherosclerosis: A multifactorial process. , 2002, Experimental and clinical cardiology.

[136]  J. Trojanowski,et al.  Neurodegenerative tauopathies. , 2001, Annual review of neuroscience.

[137]  R A Crowther,et al.  Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. , 1998, Neuroscience letters.

[138]  P. Lansbury,et al.  A detergent-insoluble membrane compartment contains A beta in vivo. , 1998, Nature medicine.