Glioblastoma multiforme of the lateral ventricle: report of nine cases

Glioblastoma multiforme is the most common lethal primary central nervous system (CNS) tumour in adults and they are rarely seen as primary intraventricular tumours. We present nine cases with lateral ventricle glioblastoma multiforme treated in our department. Seven of the nine tumours were located at the body of the lateral ventricle, whereas the other tumours were arising from septum pellicidum. Five patients were operated through an anterior transcallosal approach and four patients were operated through frontal transcortical approach. Total tumour excision was achieved only in one patient. Median survival time was 18.8 months. Three patients were alive at the end of study, and received radiotherapy and chemotherapy. Our goal was the decompressive surgery for these tumours without harming eloquent structures. In our opinion, patient's life quality is critically important in the postoperative period for these mortal tumours with rapid progression.

[1]  H. Deda,et al.  Tumours of the lateral ventricle. A retrospective review of 112 cases operated upon 1970–1997 , 2006, Neurosurgical Review.

[2]  Thomas T. Lee,et al.  Third ventricular glioblastoma multiforme: Case report , 2005, Neurosurgical Review.

[3]  H. M. Zimmerman.  BRAIN TUMORS: THEIR INCIDENCE AND CLASSIFICATION IN MAN AND THEIR EXPERIMENTAL PRODUCTION , 1969 .

[4]  J. Shinoda,et al.  Tumors at the trigone of the lateral ventricle--clinical analysis of eight cases. , 1990, Neurologia medico-chirurgica.

[5]  F. Langmark,et al.  Neoplasms of the central nervous system in Norway , 1988, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[6]  J. Frost,et al.  Subarachnoid Neoplasia: incidence and Problems of Diagnosis , 1960, Southern medical journal.

[7]  Yuta Shibamoto,et al.  Influence of extent of surgery and tumor location on treatment outcome of patients with glioblastoma multiforme treated with combined modality approach , 2005, Journal of Neuro-Oncology.

[8]  G. Zuccaro,et al.  Lateral ventricle tumors in children: a series of 54 cases , 1999, Child's Nervous System.

[9]  J. Parisi,et al.  Lateral ventricular neoplasms of the brain: differential diagnosis based on clinical, CT, and MR findings. , 1990, AJNR. American journal of neuroradiology.

[10]  G. Pendl,et al.  Surgery of tumours of the lateral ventricle , 2005, Acta Neurochirurgica.

[11]  B. Kendall,et al.  Diagnosis of masses presenting within the ventricles on computed tomography , 2004, Neuroradiology.

[12]  J. R. Rich.  A survey of cerebrospinal fluid cytology. , 1969, Bulletin of the Los Angeles neurological societies.

[13]  H. Mehdorn,et al.  Glioblastoma multiforme-report of 267 cases treated at a single institution. , 2005, Surgical neurology.

[14]  M. Mikhael,et al.  Effect of the extent of surgical resection on survival and quality of life in patients with supratentorial glioblastomas and anaplastic astrocytomas. , 1987, Neurosurgery.

[15]  J. Vézina,et al.  Magnetic resonance imaging of lateral ventricular tumours. , 1995, Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes.

[16]  Paul Park,et al.  Well-circumscribed, minimally enhancing glioblastoma multiforme of the trigone: a case report and review of the literature. , 2005, AJNR. American journal of neuroradiology.

[17]  K. Ahn,et al.  Neuronal tumors of the central nervous system: radiologic findings and pathologic correlation. , 2002, Radiographics : a review publication of the Radiological Society of North America, Inc.