A Low-Cost Amperometric Glucose Sensor Based on PCB Technology

The most successful electrochemical sensor is the glucose sensor, which has transformed the management of diabetes. Microfabrication, inkjet and screen printing are used for the realization of electrochemical sensors. However, these can be costly, time-consuming, non-standardized processes, which may be hard to adapt for low-cost mass fabrication. In this paper, we extend our previous work on PCB-based electrochemical sensing, to the realization of amperometric glucose sensors. In vitro results are presented from a multielectrode platform with on-board counter and reference electrodes, in an effort to develop low-cost, PCB-based multiparametric, multi-modal sensor arrays. A sensitivity of 3.13 µAcm−2 mM−1 was achieved.

[1]  Liang Feng,et al.  The calibration of cellphone camera-based colorimetric sensor array and its application in the determination of glucose in urine. , 2015, Biosensors & bioelectronics.

[2]  T. Prodromakis,et al.  A PCB-based electrochemical glucose biosensing platform , 2016 .

[3]  Pietro Salvo,et al.  Potentiometric sensor for non invasive lactate determination in human sweat. , 2017, Analytica chimica acta.

[4]  Guang-Zhong Yang,et al.  Electrochemicay Sensor Designs for Biomedical Implants , 2018, Implantable Sensors and Systems.

[5]  Dachao Li,et al.  A flexible electrochemical glucose sensor with composite nanostructured surface of the working electrode , 2016 .

[6]  Qing Li,et al.  Simultaneous detection of lactate and glucose by integrated printed circuit board based array sensing chip. , 2013, Analytica chimica acta.

[7]  H. Mugishima,et al.  Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area. , 2008, Diabetes research and clinical practice.

[8]  Guang-Zhong Yang,et al.  Multi-parametric rigid and flexible, low-cost, disposable sensing platforms for biomedical applications. , 2018, Biosensors & bioelectronics.

[9]  A. Simonian,et al.  Glucose, lactate, and pyruvate biosensor arrays based on redox polymer/oxidoreductase nanocomposite thin-films deposited on photolithographically patterned gold microelectrodes , 2002 .

[10]  Guang-Zhong Yang,et al.  A tetrapolar bio-impedance sensing system for gastrointestinal tract monitoring , 2015, 2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks (BSN).

[11]  Alan S Campbell,et al.  Wearable non-invasive epidermal glucose sensors: A review. , 2018, Talanta.

[12]  Amay J Bandodkar,et al.  Non-invasive wearable electrochemical sensors: a review. , 2014, Trends in biotechnology.

[13]  Guang-Zhong Yang,et al.  A wearable multisensing patch for continuous sweat monitoring. , 2017, Biosensors & bioelectronics.

[14]  Robin H. Liu,et al.  Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection. , 2004, Analytical chemistry.

[15]  Daniel J. Sadler,et al.  Integrated microfluidic components on a printed wiring board platform , 2009 .

[16]  Anthony Guiseppi-Elie,et al.  An implantable biochip to influence patient outcomes following trauma-induced hemorrhage , 2011, Analytical and bioanalytical chemistry.

[17]  C. Radhakumary,et al.  Naked eye detection of glucose in urine using glucose oxidase immobilized gold nanoparticles. , 2011, Analytical chemistry.

[18]  Bioelectric Detection of DNA and the Automation of Molecular Diagnostics , 1999 .

[19]  Marta Novell,et al.  Paper-based potentiometric ion sensors constructed on ink-jet printed gold electrodes , 2016 .