论文信息 - XenoSite server: a web-available site of metabolism prediction tool

XenoSite server: a web-available site of metabolism prediction tool

UNLABELLED Cytochrome P450 enzymes (P450s) are metabolic enzymes that process the majority of FDA-approved, small-molecule drugs. Understanding how these enzymes modify molecule structure is key to the development of safe, effective drugs. XenoSite server is an online implementation of the XenoSite, a recently published computational model for P450 metabolism. XenoSite predicts which atomic sites of a molecule--sites of metabolism (SOMs)--are modified by P450s. XenoSite server accepts input in common chemical file formats including SDF and SMILES and provides tools for visualizing the likelihood that each atomic site is a site of metabolism for a variety of important P450s, as well as a flat file download of SOM predictions. AVAILABILITY AND IMPLEMENTATION XenoSite server is available at http://swami.wustl.edu/xenosite.

Sanjay Joshua Swamidass | S. Joshua Swamidass | Matthew K. Matlock | Tyler B. Hughes | S. Joshua Joshua Swamidass

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