Morphologic study of virus‐like particles in a case of acute leukemia

Virus‐like particles, grouped in clusters not bound by a membrane, were seen in electron micrographs of fresh leucoblasts of an acute leukemic patient. They consisted of large (100‐nm diameter), round particles apparently composed of subunits. Tubular structures (30–50‐nm diameter) were also seen in leucoblasts of the same patient. The two types of structures were never seen simultaneously in the same cell. The authors review the literature pertaining to the morphology of virus‐like particles associated with malignant hematologic disease.

[1]  G. Klein.  Herpesviruses and oncogenesis , 1972, Nature.

[2]  D. Barry,et al.  Cytochemistry of tubuloreticular structures in lymphocytes from patients with systemic lupus erythematosus and in cultured human lymphoid cells: comparison to a paramyxovirus. , 1973, Laboratory investigation; a journal of technical methods and pathology.

[3]  D. Barry,et al.  Induction of tubular structures in the endoplasmic reticulum of human lymphoid cells by treatment with 5-bromo-2'-deoxyuridine. , 1973, Journal of the National Cancer Institute.

[4]  M. Tavassoli,et al.  Virus-like particles in human myeloma without paraproteinemia. , 1973, Archives of pathology.

[5]  E. Beth,et al.  Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions. , 1972, Journal of the National Cancer Institute.

[6]  J. Baringer,et al.  Tubular aggregates in endoplasmic reticulum: evidence against their viral nature. , 1972, Journal of ultrastructure research.

[7]  C. Griscelli,et al.  Endothelial Intracisternal Tubular Inclusions in a Case of Chronic Encephalitis Associated with Immunological Deficiency , 1972 .

[8]  M. Prunieras,et al.  [Inclusions in endothelial cells and lymphocytes in the course of a case of dermatomyositis]. , 1971, Revue neurologique.

[9]  E. H. Lennette,et al.  Electron microscopic studies of coronavirus. , 1971, The Journal of general virology.

[10]  B. Uzman,et al.  Tubular arrays in the endoplasmic reticulum in human tumor cells. , 1971, Laboratory investigation; a journal of technical methods and pathology.

[11]  E. M. Jensen,et al.  A human leukocyte culture with an unusual cytoplasmic envelopment of herpes-type particles. , 1971, Cancer research.

[12]  C. Garon,et al.  Propagation and micromorphology of a human leukocyte culture (M-1) and of cultures derived from its transplantation in hamsters. , 1969, Cancer research.

[13]  G. Seman,et al.  Electron‐microscopic search for virus particles in patients with leukemia and lymphoma , 1968 .

[14]  G. Seman.  Abondantes particules d'aspect viral dans les cellules du sang de patients leucémiques. , 1968 .

[15]  E. Deharven.  Human leukemic cells in tissue culture: an electron microscope survey. , 1967 .

[16]  P. Levine,et al.  Relationship between clinical status of leukemic patients and virus‐like particles in their plasma , 1967, Cancer.

[17]  D. Wright,et al.  Demonstration of virus particles in biopsy material from cases of Burkitt's tumour. , 1966, European journal of cancer.

[18]  R. Manaker,et al.  Continuous cell culture from a patient with chronic myelogenous leukemia. II. Detection of a herpes-like virus by electron microscopy. , 1966, Journal of the National Cancer Institute.

[19]  J. White,et al.  Virus‐like particles in the peripheral blood cells of two patients with chediak higashi syndrome , 1966, Cancer.

[20]  R. Dourmashkin.  An electron microscopic study of Burkitt tumour biopsies. , 1965, European journal of cancer.

[21]  H. G. Taylor,et al.  Viruses and mycoplasma (PPLO) in human leukemia , 1965, Cancer.

[22]  M. Epstein,et al.  MORPHOLOGICAL AND BIOLOGICAL STUDIES ON A VIRUS IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA , 1965, The Journal of experimental medicine.

[23]  A. Dalton,et al.  ASSOCIATION OF ELECTRON-DENSE PARTICLES WITH HUMAN ACUTE LEUKEMIA. , 1964, Journal of the National Cancer Institute.

[24]  G. Ackerman,et al.  Morphological and histochemical studies of the leukemic cells from a patient with atypical myeloblastic leukemia with special reference to intracytoplasmic mucopolysaccharide vacuoles and fibrillar formation. , 1960, Blood.

[25]  W. Bernhard.  The detection and study of tumor viruses with the electron microscope. , 1960, Cancer research.