RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
暂无分享,去创建一个
Douglas A Lauffenburger | Kevin M Haigis | D. Lauffenburger | K. Haigis | Roli Mandhana | Pamela K Kreeger | Roli Mandhana | Shannon K Alford | P. Kreeger | Shannon K. Alford
[1] B. LaFleur,et al. TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer , 2008, Clinical Cancer Research.
[2] H. Wiley,et al. Multiple Mechanisms Are Responsible for Transactivation of the Epidermal Growth Factor Receptor in Mammary Epithelial Cells* , 2008, Journal of Biological Chemistry.
[3] Douglas A. Lauffenburger,et al. Common effector processing mediates cell-specific responses to stimuli , 2007, Nature.
[4] Aihua Li,et al. Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype , 2005, Clinical & Experimental Metastasis.
[5] S. Christmas,et al. Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro. , 2000, Cytokine.
[6] A. Wolfman,et al. Endogenous c-N-Ras Provides a Steady-state Anti-apoptotic Signal* , 2000, The Journal of Biological Chemistry.
[7] L. Augenlicht,et al. Oncogenic Ras Promotes Butyrate-induced Apoptosis through Inhibition of Gelsolin Expression* , 2004, Journal of Biological Chemistry.
[8] Jonathan Melamed,et al. Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence , 2008, Cell.
[9] John G. Albeck,et al. Cue-Signal-Response Analysis of TNF-Induced Apoptosis by Partial Least Squares Regression of Dynamic Multivariate Data , 2004, J. Comput. Biol..
[10] D. Hommes,et al. New cytokine therapeutics for inflammatory bowel disease. , 2004, Cytokine.
[11] B. Kowalski,et al. Partial least-squares regression: a tutorial , 1986 .
[12] R. Coffey,et al. Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium , 2007, Journal of cellular physiology.
[13] L. Samson,et al. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. , 2008, The Journal of clinical investigation.
[14] T. Jacks,et al. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS: gelsolin complex , 2007, Oncogene.
[15] D. Lauffenburger,et al. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor‐α , 2008, Hepatology.
[16] T. Muto,et al. Genetic Alterations in Ulcerative Colitis‐associated Neoplasia Focusing on APC, K‐ras Gene and Microsatellite Instability , 1999, Japanese journal of cancer research : Gann.
[17] S. Shirasawa,et al. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. , 1993, Science.
[18] Melissa L. Kemp,et al. Quantitative Network Signal Combinations Downstream of TCR Activation Can Predict IL-2 Production Response1 , 2007, The Journal of Immunology.
[19] Eytan Domany,et al. A module of negative feedback regulators defines growth factor signaling , 2007, Nature Genetics.
[20] Alan Wells,et al. EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation , 2007, Journal of Cell Science.
[21] D. Lauffenburger,et al. A Compendium of Signals and Responses Triggered by Prodeath and Prosurvival Cytokines*S , 2005, Molecular & Cellular Proteomics.
[22] S. Keyse,et al. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases , 2007, Oncogene.
[23] Y. Nakamura,et al. Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.
[24] J. Downward. Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.
[25] D. Lauffenburger,et al. The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine Cascade , 2006, Cell.
[26] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[27] S. Soond,et al. ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking , 2005, Journal of Cell Science.
[28] C. Der,et al. Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38 , 2002, Molecular and Cellular Biology.
[29] S. Aaronson,et al. A novel dual specificity phosphatase induced by serum stimulation and heat shock. , 1994, The Journal of biological chemistry.
[30] M. Barbacid,et al. RAS oncogenes: the first 30 years , 2003, Nature Reviews Cancer.
[31] Martin Vingron,et al. A systems biological approach suggests that transcriptional feedback regulation by dual‐specificity phosphatase 6 shapes extracellular signal‐related kinase activity in RAS‐transformed fibroblasts , 2009, The FEBS journal.
[32] D. Lauffenburger,et al. A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis , 2005, Science.
[33] B. Vogelstein,et al. Prevalence of ras gene mutations in human colorectal cancers , 1987, Nature.
[34] Pietro Ghezzi,et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[35] Michael B. Yaffe,et al. Data-driven modelling of signal-transduction networks , 2006, Nature Reviews Molecular Cell Biology.
[36] J. Mayberry,et al. Colorectal cancer complicating ulcerative colitis: a review , 2000, American Journal of Gastroenterology.
[37] G. Kollias,et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. , 1999, Immunity.
[38] Forest M. White,et al. Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data , 2006, PLoS Comput. Biol..
[39] D. Notterman,et al. GROα Is Highly Expressed in Adenocarcinoma of the Colon and Down-Regulates Fibulin-1 , 2006, Clinical Cancer Research.
[40] A. Sweet-Cordero,et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon , 2008, Nature Genetics.