Elimination of carbamazepine in a non-sterile fungal bioreactor.

A properly configured bioreactor is in need to transfer the fungal biodegradation of recalcitrant pollutants into real applications. In this study, a novel plate bioreactor was designed to eliminate carbamazepine (CBZ), a widely concerned pharmaceutical, with the white rot fungus Phanerochaete chrysosporium grown on polyether foam under non-sterile conditions. The bioreactor was operated in both sequence batch and continuous modes. It was found that the sufficient supply with nutrients is crucial for an effective elimination of CBZ. Given the conditions, a high elimination of CBZ (60-80%) was achieved. The effective elimination was stable in a continuous operation for a long term (around 100 days). The high elimination of CBZ could also be achieved under real conditions with the effluent from a municipal wastewater treatment plant.

[1]  G. Feijoo,et al.  Oxidative Degradation of Azo Dyes by Manganese Peroxidase under Optimized Conditions , 2003, Biotechnology progress.

[2]  H. Okamura,et al.  Elimination of carbamazepine by repeated treatment with laccase in the presence of 1-hydroxybenzotriazole. , 2010, Journal of hazardous materials.

[3]  H. Okamura,et al.  Elimination and detoxification of triclosan by manganese peroxidase from white rot fungus. , 2010, Journal of hazardous materials.

[4]  T. Vicent,et al.  Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR. , 2010, Journal of hazardous materials.

[5]  J. Fick,et al.  Removal of oseltamivir (Tamiflu) and other selected pharmaceuticals from wastewater using a granular bioplastic formulation entrapping propagules of Phanerochaete chrysosporium. , 2010, Chemosphere.

[6]  G. Feijoo,et al.  EVALUATION OF TWO FUNGAL STRAINS FOR THE DEGRADATION OF PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) , 2010 .

[7]  K. Fukushi,et al.  Factors governing performance of continuous fungal reactor during non-sterile operation--the case of a membrane bioreactor treating textile wastewater. , 2009, Chemosphere.

[8]  Qingxiang Yang,et al.  Degradation of synthetic reactive azo dyes and treatment of textile wastewater by a fungi consortium reactor , 2009 .

[9]  John Crittenden,et al.  Oxidation of organics in retentates from reverse osmosis wastewater reuse facilities. , 2009, Water research.

[10]  A. Ledin,et al.  Fate of carbamazepine during water treatment. , 2009, Environmental science & technology.

[11]  N. Durán,et al.  Fungal Diversity and Use in Decomposition of Environmental Pollutants , 2005, Critical reviews in microbiology.

[12]  G. Feijoo,et al.  Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase , 2011, Biodegradation.

[13]  Y. Hadar,et al.  Overproduction of lignin peroxidase by Phanerochaete chrysosporium (BKM-F-1767) under nonlimiting nutrient conditions , 1993, Applied and environmental microbiology.

[14]  W. Jaeger,et al.  Clinical importance of hepatic cytochrome P450 in drug metabolism. , 1995, Drug metabolism reviews.

[15]  Damia Barcelo,et al.  Degradation of carbamazepine by Trametes versicolor in an air pulsed fluidized bed bioreactor and identification of intermediates. , 2012, Water research.

[16]  Y. Qian,et al.  Competition strategies for the incubation of white rot fungi under non-sterile conditions , 2008 .

[17]  I. Donelli,et al.  Influence of Culture Medium on Fungal Biomass Composition and Biosorption Effectiveness , 2011, Current Microbiology.

[18]  M. Sarrà,et al.  Development of a continuous process to adapt the textile wastewater treatment by fungi to industrial conditions , 2008 .

[19]  X. Wen,et al.  Degradation of tetracycline and oxytetracycline by crude lignin peroxidase prepared from Phanerochaete chrysosporium--a white rot fungus. , 2009, Chemosphere.

[20]  S. Geissen,et al.  Prediction of carbamazepine in sewage treatment plant effluents and its implications for control strategies of pharmaceutical aquatic contamination. , 2010, Chemosphere.

[21]  Jean-Louis Habib Jiwan,et al.  Elimination of endocrine disrupting chemicals nonylphenol and bisphenol A and personal care product ingredient triclosan using enzyme preparation from the white rot fungus Coriolopsis polyzona. , 2007, Chemosphere.

[22]  J. Libra,et al.  Competition strategies for the decolorization of a textile-reactive dye with the white-rot fungi Trametes versicolor under non-sterile conditions. , 2003, Biotechnology and bioengineering.

[23]  H. Okamura,et al.  Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation , 2010, Biodegradation.

[24]  M. Tien,et al.  Lignin peroxidase of Phanerochaete chrysosporium , 1988 .

[25]  Gloria Caminal,et al.  Degradation of naproxen and carbamazepine in spiked sludge by slurry and solid-phase Trametes versicolor systems. , 2010, Bioresource technology.

[26]  F. Spina,et al.  Scale-up of a bioprocess for textile wastewater treatment using Bjerkandera adusta. , 2010, Bioresource technology.

[27]  O. Kusakabe,et al.  Biodegradation characteristics of pharmaceutical substances by whole fungal culture Trametes versicolor and its laccase. , 2010 .

[28]  Sven-Uwe Geissen,et al.  In vitro degradation of carbamazepine and diclofenac by crude lignin peroxidase. , 2010, Journal of hazardous materials.

[29]  Y. Terashima,et al.  Activities of ligninolytic enzymes of the white rot fungus, Phanerochaete chrysosporium and its recalcitrant substance degradability , 1996 .

[30]  M. Fountoulakis,et al.  Pharmaceuticals and health care products in wastewater effluents: the example of carbamazepine , 2003 .

[31]  D. Bathen,et al.  Physical waves in adsorption technology—an overview , 2003 .

[32]  P. Blánquez,et al.  Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR. , 2010, Bioresource technology.

[33]  T. Vicent,et al.  White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR. , 2010, Chemosphere.

[34]  S. Geissen,et al.  Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies. , 2008, Chemosphere.

[35]  H. Cabana,et al.  Immobilization of laccase from the white rot fungus Coriolopsis polyzona and use of the immobilized biocatalyst for the continuous elimination of endocrine disrupting chemicals. , 2009, Bioresource technology.