Differentiation of complex vapor mixtures using versatile DNA-carbon nanotube chemical sensor arrays.

Vapor sensors based on functionalized carbon nanotubes (NTs) have shown great promise, with high sensitivity conferred by the reduced dimensionality and exceptional electronic properties of the NT. Critical challenges in the development of NT-based sensor arrays for chemical detection include the demonstration of reproducible fabrication methods and functionalization schemes that provide high chemical diversity to the resulting sensors. Here, we outline a scalable approach to fabricating arrays of vapor sensors consisting of NT field effect transistors functionalized with single-stranded DNA (DNA-NT). DNA-NT sensors were highly reproducible, with responses that could be described through equilibrium thermodynamics. Target analytes were detected even in large backgrounds of volatile interferents. DNA-NT sensors were able to discriminate between highly similar molecules, including structural isomers and enantiomers. The sensors were also able to detect subtle variations in complex vapors, including mixtures of structural isomers and mixtures of many volatile organic compounds characteristic of humans.

[1]  A. Hill,et al.  The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves , 1910 .

[2]  M. Fukuda,et al.  Elucidation of chemical compounds responsible for foot malodour , 1990, The British journal of dermatology.

[3]  C. Wysocki,et al.  Cross-adaptation of sweaty-smelling 3-methyl-2-hexenoic acid by its ethyl esters is determined by structural similarity , 1996 .

[4]  Craig A. Grimes,et al.  Gas sensing characteristics of multi-wall carbon nanotubes , 2001 .

[5]  Riichiro Saito,et al.  Raman spectroscopy on isolated single wall carbon nanotubes , 2002 .

[6]  Alexander Star,et al.  Electronic Detection of Specific Protein Binding Using Nanotube FET Devices , 2003 .

[7]  Qian Wang,et al.  Toward Large Arrays of Multiplex Functionalized Carbon Nanotube Sensors for Highly Sensitive and Selective Molecular Detection. , 2003, Nano letters.

[8]  Y. J. Chen,et al.  Low-resistance gas sensors fabricated from multiwalled carbon nanotubes coated with a thin tin oxide layer , 2004 .

[9]  G. Preti,et al.  An investigation of human apocrine gland secretion for axillary odor precursors , 1992, Journal of Chemical Ecology.

[10]  Vikram Joshi,et al.  Nanoelectronic Carbon Dioxide Sensors , 2004 .

[11]  Antonello Cutolo,et al.  Alcohol detection using carbon nanotubes acoustic and optical sensors , 2004 .

[12]  Andrew I. Spielman,et al.  Analysis of characteristic human female axillary odors: Qualitative comparison to males , 1996, Journal of Chemical Ecology.

[13]  M. Strano,et al.  Near-infrared optical sensors based on single-walled carbon nanotubes , 2004, Nature materials.

[14]  E. Brenna,et al.  Biocatalytic preparation of natural flavours and fragrances. , 2005, Trends in biotechnology.

[15]  Alan Gelperin,et al.  DNA-decorated carbon nanotubes for chemical sensing , 2005, Nano letters.

[16]  E. S. Snow,et al.  Chemical Detection with a Single-Walled Carbon Nanotube Capacitor , 2005, Science.

[17]  Chengbu Liu,et al.  Novel chemical sensor for cyanides: boron-doped carbon nanotubes. , 2006, The journal of physical chemistry. B.

[18]  Alexander Star,et al.  Gas sensor array based on metal-decorated carbon nanotubes. , 2006, The journal of physical chemistry. B.

[19]  R. Marchelli,et al.  Chirality as a tool in nucleic acid recognition: principles and relevance in biotechnology and in medicinal chemistry. , 2007, Chirality.

[20]  Yehudit Hasin,et al.  Genetic Elucidation of Human Hyperosmia to Isovaleric Acid , 2007, PLoS biology.

[21]  Douglas R. Kauffman,et al.  Carbon nanotube gas and vapor sensors. , 2008, Angewandte Chemie.

[22]  Luisa Torsi,et al.  A sensitivity-enhanced field-effect chiral sensor. , 2008, Nature materials.

[23]  H. Chan,et al.  Self-assembly of perfunctionalized beta-cyclodextrins on a quartz crystal microbalance for real-time chiral recognition. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[24]  C. Wysocki,et al.  Analyses of volatile organic compounds from human skin , 2008, The British journal of dermatology.

[25]  M. Klein,et al.  Probing the structure of DNA-carbon nanotube hybrids with molecular dynamics. , 2007, Nano letters.

[26]  C. Wysocki,et al.  Cross-adaptation of a model human stress-related odour with fragrance chemicals and ethyl esters of axillary odorants: gender-specific effects. , 2009 .

[27]  Chiral sensing using a complementary metal-oxide semiconductor-integrated three-transducer microsensor system. , 2009, Analytical chemistry.

[28]  Gianluca Piazza,et al.  Nanoenabled microelectromechanical sensor for volatile organic chemical detection , 2009 .

[29]  D. Pribat,et al.  Carbon nanotubes based transistors as gas sensors: State of the art and critical review , 2009 .

[30]  Chongwu Zhou,et al.  Wafer-scale fabrication of separated carbon nanotube thin-film transistors for display applications. , 2009, Nano letters.

[31]  Alphus D. Wilson,et al.  Applications and Advances in Electronic-Nose Technologies , 2009, Sensors.

[32]  Axel Kohlmeyer,et al.  Free energy landscape of a DNA-carbon nanotube hybrid using replica exchange molecular dynamics. , 2009, Nano letters.

[33]  M. Klein,et al.  The nature of DNA-base-carbon-nanotube interactions. , 2010, Small.

[34]  Ye Lu,et al.  DNA-decorated graphene chemical sensors , 2010 .

[35]  Douglas R. Kauffman,et al.  Understanding the sensor response of metal-decorated carbon nanotubes. , 2010, Nano letters.

[36]  A. T. Johnson,et al.  Optimized photolithographic fabrication process for carbon nanotube devices , 2011 .

[37]  Alan Gelperin,et al.  Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins. , 2011, ACS nano.

[38]  Toward quantifying the electrostatic transduction mechanism in carbon nanotube molecular sensors. , 2012, Journal of the American Chemical Society.

[39]  A. Gelperin,et al.  DNA-decorated carbon nanotube-based FETs as ultrasensitive chemical sensors: Discrimination of homologues, structural isomers, and optical isomers , 2012 .

[40]  Jeffrey Bokor,et al.  Comparative study of solution-processed carbon nanotube network transistors , 2012 .