Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology.

[1]  S. Rai,et al.  Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor , 2013, Neuroscience.

[2]  Rakesh Shukla,et al.  A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats , 2013, Journal of Neuroimmunology.

[3]  Alberto Lleó,et al.  Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease , 2012, Acta Neuropathologica.

[4]  D. Souza,et al.  Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats. , 2012, Current Alzheimer research.

[5]  J. Trojanowski,et al.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. , 2012, Journal of medicinal chemistry.

[6]  Shakir Ali,et al.  Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats. , 2012, European journal of pharmacology.

[7]  F. van Leuven,et al.  Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease , 2012, International journal of Alzheimer's disease.

[8]  Rakesh Shukla,et al.  A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats. , 2012, Life sciences.

[9]  Hui Zheng,et al.  Role of APP and Aβ in synaptic physiology. , 2012, Current Alzheimer research.

[10]  I. Ferrer,et al.  PP2A and Alzheimer disease. , 2012, Current Alzheimer research.

[11]  E. Capetillo-Zarate,et al.  Intraneuronal Aβ Accumulation, Amyloid Plaques, and Synapse Pathology in Alzheimer’s Disease , 2012, Neurodegenerative Diseases.

[12]  A. C. Tramontina,et al.  Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia , 2012, Behavioural Brain Research.

[13]  Shakir Ali,et al.  Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain , 2011, Pharmacology Biochemistry and Behavior.

[14]  Yahui Kong,et al.  Oxidative Stress, Mitochondrial Dysfunction, and Aging , 2011, Journal of signal transduction.

[15]  Anja Kunze,et al.  Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies. , 2011, Biotechnology and bioengineering.

[16]  J. Ávila,et al.  Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[17]  E. Cemeli,et al.  Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type. , 2011, Toxicon : official journal of the International Society on Toxinology.

[18]  K. Chopra,et al.  Neurobiological aspects of Alzheimer's disease , 2011, Expert opinion on therapeutic targets.

[19]  F. Terro,et al.  Post-translational modifications of tau protein: Implications for Alzheimer's disease , 2011, Neurochemistry International.

[20]  J. Simpkins,et al.  An okadaic acid-induced model of tauopathy and cognitive deficiency , 2010, Brain Research.

[21]  D. Coulter,et al.  Axonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons , 2010, Proceedings of the National Academy of Sciences.

[22]  P. Dolan,et al.  The role of tau kinases in Alzheimer's disease. , 2010, Current opinion in drug discovery & development.

[23]  J. Simpkins,et al.  Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner , 2010, Brain Research.

[24]  Seung-Yong Yoon,et al.  Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model. , 2010, Biochemical and biophysical research communications.

[25]  Hyoung-Gon Lee,et al.  Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease , 2010, Neurobiology of Disease.

[26]  R. Veerhuis,et al.  Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease , 2010, Neurodegenerative Diseases.

[27]  G. Saxena,et al.  Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity , 2010, Brain Research.

[28]  G. Perkins,et al.  Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. , 2009, Biochimica et biophysica acta.

[29]  Leonard Petrucelli,et al.  The role of tau in neurodegeneration , 2009, Molecular Neurodegeneration.

[30]  J. Marcusson,et al.  Oxidative stress induces macroautophagy of amyloid beta-protein and ensuing apoptosis. , 2009, Free radical biology & medicine.

[31]  J. Simpkins,et al.  Mechanism of okadaic acid‐induced neuronal death and the effect of estrogens , 2009, Journal of neurochemistry.

[32]  Y. Huh,et al.  Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis , 2009, Neuroscience Letters.

[33]  R. Agrawal,et al.  Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain , 2008, Journal of Neuroimmunology.

[34]  J. Simpkins,et al.  Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection. , 2008, Endocrinology.

[35]  H. Tanila,et al.  Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A , 2008, Neurobiology of Disease.

[36]  M. Zvelebil,et al.  Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases* , 2008, Journal of Biological Chemistry.

[37]  M. Asashima,et al.  Neural Stem Cells Improve Learning and Memory in Rats with Alzheimer’s Disease , 2008, Pathobiology.

[38]  Sotirios G. Ziavras,et al.  Robust scalability analysis and SPM case studies , 2008, The Journal of Supercomputing.

[39]  D. Nicholls,et al.  Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity , 2007, Journal of neuroscience research.

[40]  Yong Cheng,et al.  [Protective effect of (-) clausenamide against neurotoxicity induced by okadaic acid and beta-amyloid peptide25-35]. , 2007, Yao xue xue bao = Acta pharmaceutica Sinica.

[41]  J. Trojanowski,et al.  Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.

[42]  B. Platt,et al.  Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases , 2007, Journal of neurochemistry.

[43]  P. Rosenberg,et al.  NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors , 2007, Brain Research.

[44]  J. Toldi,et al.  Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders , 2007, Journal of the Neurological Sciences.

[45]  Cam Patterson,et al.  The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. , 2007, The Journal of clinical investigation.

[46]  K. Davies,et al.  Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. , 2006, The Biochemical journal.

[47]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[48]  M. J. Moyano,et al.  Protective effect of carvedilol on oxidative stress induced by okadaic acid in N1E-115 cells. , 2006, Pharmacological research.

[49]  Dong Hou Kim,et al.  BACE inhibitor reduces APP-β-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration , 2006, Neurobiology of Disease.

[50]  C. Gong,et al.  Concurrent alterations of O‐GlcNAcylation and phosphorylation of tau in mouse brains during fasting , 2006, The European journal of neuroscience.

[51]  D. Barros,et al.  Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats. , 2006, Chemico-biological interactions.

[52]  J. Tew,et al.  Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses. , 2006, Journal of periodontal research.

[53]  M. Kivipelto,et al.  High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice , 2005, FEBS letters.

[54]  Damian S Shin,et al.  Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. , 2005, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[55]  J. Simpkins,et al.  Role of Protein Phosphatases in Estrogen-Mediated Neuroprotection , 2005, The Journal of Neuroscience.

[56]  Haiyun Xu,et al.  Olanzapine Attenuates the Okadaic Acid-Induced Spatial Memory Impairment and Hippocampal Cell Death in Rats , 2005, Neuropsychopharmacology.

[57]  T. Robbins,et al.  Cognitive Sequelae of Intravenous Amphetamine Self-Administration in Rats: Evidence for Selective Effects on Attentional Performance , 2005, Neuropsychopharmacology.

[58]  Robert W Berry,et al.  Tau, tangles, and Alzheimer's disease. , 2005, Biochimica et biophysica acta.

[59]  I. Grundke‐Iqbal,et al.  Tau pathology in Alzheimer disease and other tauopathies. , 2005, Biochimica et biophysica acta.

[60]  C. Gong,et al.  Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit , 2004, Neuroscience.

[61]  G. Collingridge,et al.  Receptor trafficking and synaptic plasticity , 2004, Nature Reviews Neuroscience.

[62]  D. Westaway,et al.  Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. , 2004, Journal of psychiatry & neuroscience : JPN.

[63]  B. Winblad,et al.  Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain , 2004, Neuroreport.

[64]  Jian-Zhi Wang,et al.  Melatonin attenuates isoproterenol‐induced protein kinase A overactivation and tau hyperphosphorylation in rat brain , 2004, Journal of pineal research.

[65]  I. Santana,et al.  Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity , 2004, Journal of neurochemistry.

[66]  I. Grundke‐Iqbal,et al.  Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration , 2004, FEBS letters.

[67]  M. Ehlers,et al.  Learning from NMDA Receptor Trafficking: Clues to the Development and Maturation of Glutamatergic Synapses , 2004, Neurosignals.

[68]  N. Lagos,et al.  First evidence of Dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords. , 2004, Toxicon : official journal of the International Society on Toxinology.

[69]  I. Santana,et al.  Cytochrome c oxidase is decreased in Alzheimer’s disease platelets , 2004, Neurobiology of Aging.

[70]  K. Ng,et al.  Novel effects on memory observed following unilateral intracranial administration of okadaic acid, cyclosporin A, FK506 and [MeVal4]CyA , 2003, Brain Research.

[71]  R. Nitsch,et al.  Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. , 2003, The American journal of pathology.

[72]  W. Liu,et al.  Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal , 2003, Cell Death and Differentiation.

[73]  I. Grundke‐Iqbal,et al.  Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices , 2003, Neuroscience Letters.

[74]  R. Veerhuis,et al.  The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications. , 2002, Drugs of today.

[75]  B. Herman,et al.  Apoptosis and successful aging , 2002, Mechanisms of Ageing and Development.

[76]  Jian-Zhi Wang,et al.  Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin. , 2002, Acta pharmacologica Sinica.

[77]  I. Grundke‐Iqbal,et al.  Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid‐treated SY5Y cells , 2001, FEBS letters.

[78]  T. Hirai,et al.  Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT , 2001, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[79]  S. Lees-Miller,et al.  Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity* , 2001, The Journal of Biological Chemistry.

[80]  S. Hatem,et al.  Cumulative inactivation of the outward potassium current: a likely mechanism underlying electrical memory in human atrial myocytes. , 2001, Journal of molecular and cellular cardiology.

[81]  Weiqin Zhao,et al.  Concentration-Dependent Effects of Protein Phosphatase (PP) Inhibitors Implicate PP1 and PP2A in Different Stages of Memory Formation , 2001, Neurobiology of Learning and Memory.

[82]  J. Kuret,et al.  C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. , 2000, Journal of cell science.

[83]  G. Barrionuevo,et al.  Protein Phosphatase-Mediated Regulation of Protein Kinase C during Long-Term Depression in the Adult Hippocampus In Vivo , 2000, The Journal of Neuroscience.

[84]  M. Gurney,et al.  Tau Phosphorylation at Serine 396 and Serine 404 by Human Recombinant Tau Protein Kinase II Inhibits Tau's Ability to Promote Microtubule Assembly* , 2000, The Journal of Biological Chemistry.

[85]  M. Mather,et al.  Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria , 2000, Biochemical and biophysical research communications.

[86]  T. Suuronen,et al.  Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells. , 2000, Biochemical pharmacology.

[87]  J. Wegiel,et al.  Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain , 2000, The Journal of Biological Chemistry.

[88]  G. Wilcock,et al.  The cholinergic hypothesis of Alzheimer’s disease: a review of progress , 1999, Journal of neurology, neurosurgery, and psychiatry.

[89]  C. Arias,et al.  The Protein Phosphatase Inhibitor Okadaic Acid Induces Heat Shock Protein Expression and Neurodegeneration in Rat Hippocampusin Vivo , 1998, Experimental Neurology.

[90]  R. Quirion,et al.  Amyloid β‐Peptide Inhibits High‐Affinity Choline Uptake and Acetylcholine Release in Rat Hippocampal Slices , 1998 .

[91]  Y. Nakamura,et al.  Basic and clinical studies on the measurement of tau protein in cerebrospinal fluid as a biological marker for Alzheimer's disease and related disorders: multicenter study in Japan. , 1998, Methods and findings in experimental and clinical pharmacology.

[92]  M. Emmerling,et al.  Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide. , 1997, Immunopharmacology.

[93]  H. Paudel.  The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. , 1997, The Journal of biological chemistry.

[94]  R. Nitsch.  From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease. , 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[95]  P. Francis.  Pyramidal neurone modulation: a therapeutic target for Alzheimer's disease. , 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[96]  A. Novelli,et al.  Inhibition of protein phosphatases induces IGF‐1‐blocked neurotrophin‐insensitive neuronal apoptosis , 1996, FEBS letters.

[97]  T. Radebaugh,et al.  Behavioral Approaches to the Treatment of Alzheimer's Disease: Research Strategies , 1996, International Psychogeriatrics.

[98]  U. Wagner,et al.  Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. , 1996, Journal of cell science.

[99]  D. Gurwitz,et al.  Activation of m1 Muscarinic Acetylcholine Receptor Regulates τ Phosphorylation in Transfected PC12 Cells , 1996, Journal of neurochemistry.

[100]  Simon Lovestone,et al.  Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells , 1994, Current Biology.

[101]  J. Trojanowski,et al.  Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau , 1994, Neuron.

[102]  T. Murakami,et al.  Characterization of multiple molecular forms of Mg(2+)-dependent protein phosphatase from Saccharomyces cerevisiae. , 1994, Journal of biochemistry.

[103]  Weiqin Zhao,et al.  Effect of PKC inhibitors and activators on memory , 1994, Behavioural Brain Research.

[104]  I. Grundke‐Iqbal,et al.  Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain , 1993, Journal of neurochemistry.

[105]  C. Arias,et al.  Okadaic Acid Induces Early Changes in Microtubule‐Associated Protein 2 and γ Phosphorylation Prior to Neurodegeneration in Cultured Cortical Neurons , 1993, Journal of neurochemistry.

[106]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[107]  M. Lanotte,et al.  The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. , 1991, Experimental cell research.

[108]  R. Huganir,et al.  Regulation of neurotransmitter receptor desensitization by protein phosphorylation , 1990, Neuron.

[109]  R. Black,et al.  Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation. , 1990, Archives of neurology.

[110]  S. DeKosky,et al.  Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity , 1990, Annals of neurology.

[111]  A. Takai,et al.  Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. , 1988, The Biochemical journal.

[112]  A. Takai,et al.  Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin , 1987, FEBS letters.

[113]  A. Procter,et al.  Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease , 1986, Neuroscience Letters.

[114]  M. Esiri,et al.  Alzheimer's disease Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities , 1982, Journal of the Neurological Sciences.

[115]  Jianhua Shi,et al.  PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. , 2010, Journal of Alzheimer's disease : JAD.

[116]  Jian-Zhi Wang,et al.  Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. , 2010, Journal of Alzheimer's disease : JAD.

[117]  G. Perry,et al.  Mitochondria: a therapeutic target in neurodegeneration. , 2010, Biochimica et biophysica acta.

[118]  H. Manev,et al.  Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9 , 2007, Journal of Molecular Neuroscience.

[119]  Akihiko Takashima,et al.  GSK-3 is essential in the pathogenesis of Alzheimer's disease. , 2006, Journal of Alzheimer's disease : JAD.

[120]  S. Konermann,et al.  Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients. , 2006, Acta Neuropathologica.

[121]  A. Komori,et al.  Expression of the tumor necrosis factorα gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes , 2005, Journal of Cancer Research and Clinical Oncology.

[122]  D. Butterfield,et al.  The Glutamatergic System and Alzheimer’s Disease , 2003, CNS drugs.

[123]  M. L. Souto,et al.  Okadaic acid, useful tool for studying cellular processes. , 2002, Current medicinal chemistry.

[124]  T. Nabeshima,et al.  Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats , 2001, Journal of Neural Transmission.

[125]  R. Veerhuis,et al.  Neuroinflammation and Alzheimer disease: clinical and therapeutic implications. , 2000, Alzheimer disease and associated disorders.

[126]  A. Komori,et al.  Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. , 1997, Journal of cancer research and clinical oncology.

[127]  A. Novelli,et al.  The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons. , 1991, Life sciences.

[128]  P. Cohen.  The structure and regulation of protein phosphatases. , 1989, Annual review of biochemistry.

[129]  P. Whitehouse,et al.  Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders. , 1987, Journal of neural transmission. Supplementum.