Carbon repression in Aspergilli.

Many microorganisms prefer easily metabolizable carbon sources over alternative, less readily metabolized carbon sources. One of the mechanisms to achieve this is repression of the synthesis of enzymes related to catabolism of the alternative carbon sources, i.e. carbon repression. It is now clear that in Aspergillus nidulans and Aspergillus niger the repressor protein CREA plays a major role in carbon repression. CREA inhibits transcription of many target genes by binding to specific sequences in the promoter of these genes. Unfortunately there is little information on other components of the signalling pathway that triggers repression by CREA. In this review we summarize the current understanding of carbon repression in Aspergilli.

[1]  J. Kelly,et al.  Analysis of mutations in the creA gene involved in carbon catabolite repression in Aspergillus nidulans. , 1996, Canadian journal of microbiology.

[2]  J. Visser,et al.  Characterisation of the Aspergillus nidulans frA1 mutant: hexose phosphorylation and apparent lack of involvement of hexokinase in glucose repression. , 1996, FEMS microbiology letters.

[3]  D. Ramón,et al.  Purification and regulation of the synthesis of a β-xylosidase from Aspergillus nidulans , 1996 .

[4]  C. Scazzocchio,et al.  Carbon catabolite repression in Aspergillus nidulans: a review , 1995 .

[5]  S. Zeilinger,et al.  Crel, the carbon catabolite repressor protein from Trichoderma reesei , 1995, FEBS letters.

[6]  D. Stillman,et al.  Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[7]  George,et al.  An extreme creA mutation in Aspergillus nidulans has severe effects on D-glucose utilization. , 1995, Microbiology.

[8]  S. Fillinger,et al.  The basal level of transcription of the alc genes in the ethanol regulon in Aspergillus nidulans is controlled both by the specific transactivator AlcR and the general carbon catabolite repressor CreA , 1995, FEBS letters.

[9]  E. Espeso,et al.  Carbon regulation of penicillin biosynthesis in Aspergillus nidulans: A minor effect of mutations in creB and creC , 1995 .

[10]  J. Visser,et al.  Cloning, characterization and expression of pepF, a gene encoding a serine carboxypeptidase from Aspergillus niger. , 1994, Gene.

[11]  J. Thevelein.  Signal transduction in yeast , 1994, Yeast.

[12]  J. Visser,et al.  Arabinase gene expression in Aspergillus niger: indications for coordinated regulation. , 1994, Microbiology.

[13]  B. Felenbok,et al.  The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR‐specific transactivator. , 1994, The EMBO journal.

[14]  J. Visser,et al.  Regulation of the xylanase‐encoding xlnA gene of Aspergilius tubigensis , 1994, Molecular microbiology.

[15]  G. Nanda,et al.  Physiological studies on xylose induction and glucose repression of xylanolytic enzymes in Aspergillus sydowii MG49 , 1994 .

[16]  E. Espeso,et al.  In vitro binding of the two‐finger repressor CreA to several consensus and non‐consensus sites at the ipnA upstream region is context dependent , 1994, FEBS letters.

[17]  C. Scazzocchio,et al.  Two different, adjacent and divergent zinc finger binding sites are necessary for CREA‐mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans. , 1994, The EMBO journal.

[18]  E. Espeso,et al.  pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene. , 1993, The EMBO journal.

[19]  J. Kelly,et al.  The Aspergillus niger carbon catabolite repressor encoding gene, creA. , 1993, Gene.

[20]  J. Kelly,et al.  Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon cataboiite repression in Aspergillus nidulans , 1993, Molecular microbiology.

[21]  J. Gancedo.  Carbon catabolite repression in yeast. , 1992, European journal of biochemistry.

[22]  E. Espeso,et al.  Carbon catabolite repression can account for the temporal pattern of expression of a penicillin biosynthetic gene in Aspergillus nidulans , 1992, Molecular microbiology.

[23]  J. Kelly,et al.  Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans , 1991, Molecular and cellular biology.

[24]  M. Hynes,et al.  The amdR product and a CCAAT-binding factor bind to adjacent, possibly overlapping DNA sequences in the promoter region of the Aspergillus nidulans amdS gene. , 1991, Nucleic acids research.

[25]  J. Visser,et al.  Glycerol catabolism in Aspergillus nidulans. , 1991, Journal of general microbiology.

[26]  H. Ronne,et al.  Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. , 1990, The EMBO journal.

[27]  D. Tollervey,et al.  Notes An inversion truncating the creA gene of Aspergillus niduians results in carbon catabolite derepression , 1990 .

[28]  R. Dean,et al.  Regulation of the Aspergillus nidulans pectate lyase gene (pelA). , 1989, The Plant cell.

[29]  J. Kelly,et al.  The regulation of phosphoenolpyruvate carboxykinase and the NADP-linked malic enzyme in Aspergillus nidulans. , 1981, Journal of general microbiology.

[30]  H. Arst,et al.  Carbon catabolite repression in Aspergillos nidulans. , 1975, European journal of biochemistry.

[31]  Y. Hah,et al.  Regulation of β-glucosidase biosynthesis in Aspergillus nidulans , 1996 .

[32]  H. Ronne.  Glucose repression in fungi. , 1995, Trends in genetics : TIG.

[33]  Kelly Jm,et al.  Carbon catabolite repression. , 1994 .

[34]  F. Piñaga,et al.  Xylanase production in Aspergillus nidulans: induction and carbon catabolite repression , 1994 .