CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses

CXCR4 identifies an immobilized BM precursor (i.e., transitional premonocyte [TpMo]) that proliferates and replenishes mature Ly6Chi monocytes in mice and humans. Upon entering the circulation, CXCR4 governs monocyte margination in the lung vasculature.

[1]  D. Metzger,et al.  Patrolling monocytes control tumor metastasis to the lung , 2015, Science.

[2]  S. Morrison,et al.  A perisinusoidal niche for extramedullary haematopoiesis in the spleen , 2015, Nature.

[3]  Hosung Jung,et al.  Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4 , 2015, PloS one.

[4]  C. Hedrick,et al.  Nonclassical patrolling monocyte function in the vasculature. , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[5]  S. Ganesan,et al.  CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs, lung, and blood in mice , 2015, European journal of immunology.

[6]  Steffen Jung,et al.  Macrophages: development and tissue specialization. , 2015, Annual review of immunology.

[7]  Jian Huang,et al.  CXCR4 Blockade Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats , 2015, Neonatology.

[8]  R. Weissleder,et al.  Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis , 2015, Science.

[9]  F. Ginhoux,et al.  Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L−/− reporter mouse by multiphoton intravital microscopy , 2015, Journal of leukocyte biology.

[10]  Michael Poidinger,et al.  High-dimensional analysis of the murine myeloid cell system , 2014, Nature Immunology.

[11]  F. Ginhoux,et al.  Monocytes and macrophages: developmental pathways and tissue homeostasis , 2014, Nature Reviews Immunology.

[12]  Sean C. Bendall,et al.  Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development , 2014, Cell.

[13]  T. Nagasawa.  CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4 , 2014, Journal of Molecular Medicine.

[14]  S. Pittaluga,et al.  A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor. , 2014, Blood.

[15]  Åsa K. Björklund,et al.  Full-length RNA-seq from single cells using Smart-seq2 , 2014, Nature Protocols.

[16]  D. Barber,et al.  Intravascular staining for discrimination of vascular and tissue leukocytes , 2014, Nature Protocols.

[17]  A. Miyawaki,et al.  Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators , 2013, Development.

[18]  F. Ginhoux,et al.  Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow , 2013, The Journal of experimental medicine.

[19]  Constance Auvynet,et al.  Pharmacological Inhibition of the Chemokine Receptor, CX3CR1, Reduces Atherosclerosis in Mice , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[20]  A. Chawla,et al.  Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes , 2013, Science.

[21]  S. Amigorena,et al.  Inflammatory dendritic cells in mice and humans. , 2013, Trends in immunology.

[22]  C. Combadière,et al.  CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice. , 2013, Blood.

[23]  J. Krijgsveld,et al.  Origin of monocytes and macrophages in a committed progenitor , 2013, Nature Immunology.

[24]  Jianzhu Chen,et al.  Human Fetal Hepatic Progenitor Cells Are Distinct from, but Closely Related to, Hematopoietic Stem/Progenitor Cells , 2013, Stem cells.

[25]  Sean C. Bendall,et al.  viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia , 2013, Nature Biotechnology.

[26]  F. Ginhoux,et al.  Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. , 2013, Immunity.

[27]  Leo M. Carlin,et al.  Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal , 2013, Cell.

[28]  Daniel G. Anderson,et al.  Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice , 2013, Circulation.

[29]  C. Scheiermann,et al.  Circadian control of the immune system , 2013, Nature Reviews Immunology.

[30]  A. Mildner,et al.  Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.

[31]  P. Rohrlich,et al.  Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry , 2012, Orphanet Journal of Rare Diseases.

[32]  K. Dhaliwal,et al.  Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury. , 2012, American journal of respiratory and critical care medicine.

[33]  L. Fiette,et al.  Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice. , 2012, Blood.

[34]  P. Libby,et al.  Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions , 2012, Circulation.

[35]  P. Libby,et al.  Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis , 2012, The Journal of experimental medicine.

[36]  E. Pamer,et al.  Monocyte recruitment during infection and inflammation , 2011, Nature Reviews Immunology.

[37]  L. Ng,et al.  Visualizing the neutrophil response to sterile tissue injury in mouse dermis reveals a three-phase cascade of events. , 2011, The Journal of investigative dermatology.

[38]  Daniel G. Anderson,et al.  Therapeutic siRNA silencing in inflammatory monocytes , 2011, Nature Biotechnology.

[39]  Wing-Cheong Wong,et al.  Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. , 2011, Blood.

[40]  F. Geissmann,et al.  The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes , 2011, Nature Immunology.

[41]  T. Hohl,et al.  Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. , 2011, Immunity.

[42]  R. Glenny,et al.  Stabilized Imaging of Immune Surveillance in the Mouse Lung , 2010, Nature Methods.

[43]  Andrew E. Gelman,et al.  In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation , 2010, Proceedings of the National Academy of Sciences.

[44]  J. Casanova,et al.  Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors , 2010, Immunity.

[45]  M. Pittet,et al.  Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. , 2010, Circulation.

[46]  F. Tacke,et al.  Comparison of gene expression profiles between human and mouse monocyte subsets. , 2010, Blood.

[47]  P. Libby,et al.  Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites , 2009, Science.

[48]  D. Link,et al.  CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. , 2009, Blood.

[49]  I. Weissman,et al.  CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. , 2009, Blood.

[50]  N. Van Rooijen,et al.  Mobilization and Margination of Bone Marrow Gr-1high Monocytes during Subclinical Endotoxemia Predisposes the Lungs toward Acute Injury1 , 2009, The Journal of Immunology.

[51]  S. Ratcliffe,et al.  GEEQBOX: A MATLAB Toolbox for Generalized Estimating Equations and Quasi-Least Squares , 2008 .

[52]  T. Hohl,et al.  Monocyte-mediated defense against microbial pathogens. , 2008, Annual review of immunology.

[53]  Michael Hahsler,et al.  Getting Things in Order: An Introduction to the R Package seriation , 2008 .

[54]  A. Cumano,et al.  Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior , 2007, Science.

[55]  Steffen Jung,et al.  Monocytes give rise to mucosal, but not splenic, conventional dendritic cells , 2007, The Journal of experimental medicine.

[56]  F. Tacke,et al.  Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. , 2007, The Journal of clinical investigation.

[57]  Paul A Clemons,et al.  The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease , 2006, Science.

[58]  E. Pamer,et al.  Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 , 2006, Nature Immunology.

[59]  K. Ley,et al.  Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[60]  L. Notarangelo,et al.  Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome. , 2004, Blood.

[61]  K. Malcolm,et al.  Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. , 2004, Blood.

[62]  S. Rankin,et al.  Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. , 2003, Immunity.

[63]  J. Hogg,et al.  A novel method to quantify the turnover and release of monocytes from the bone marrow using the thymidine analog 5'-bromo-2'-deoxyuridine. , 2003, American journal of physiology. Cell physiology.

[64]  R. Gorlin,et al.  Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease , 2003, Nature Genetics.

[65]  Dominique Schols,et al.  AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. , 2002, The American journal of pathology.

[66]  W. Kuebler,et al.  The Marginated Pool , 2002, European Surgical Research.

[67]  W. Reith,et al.  Conditional gene targeting in macrophages and granulocytes using LysMcre mice , 1999, Transgenic Research.

[68]  J. Hogg,et al.  Polymorphonuclear leukocyte transit times in bone marrow during streptococcal pneumonia. , 1996, The American journal of physiology.

[69]  J. Hogg,et al.  Comparison of neutrophil and capillary diameters and their relation to neutrophil sequestration in the lung. , 1993, Journal of applied physiology.

[70]  W. Macnee,et al.  New perspectives on basic mechanisms in lung disease. 2. Neutrophil traffic in the lungs: role of haemodynamics, cell adhesion, and deformability. , 1993, Thorax.

[71]  D. Rogers.  New perspectives on basic mechanisms in lung disease , 1992 .

[72]  S. Nishikawa,et al.  Expression and function of c-kit in hemopoietic progenitor cells , 1991, The Journal of experimental medicine.

[73]  J. Hogg.  Neutrophil kinetics and lung injury. , 1987, Physiological reviews.

[74]  R. van Furth,et al.  Distribution of blood monocytes between a marginating and a circulating pool , 1986, The Journal of experimental medicine.

[75]  J. Hogg,et al.  Effect of pulmonary blood flow on the exchange between the circulating and marginating pool of polymorphonuclear leukocytes in dog lungs. , 1982, The Journal of clinical investigation.

[76]  R. van Furth,et al.  Characteristics of human mononuclear phagocytes. , 1979, Blood.

[77]  E. Schultz,et al.  Pulmonary capillary length in dogs, cat and rabbit. , 1968, Respiration physiology.

[78]  H. Bierman,et al.  The release of leukocytes and platelets from the pulmonary circulation by epinephrine. , 1952, Blood.

[79]  F. Ginhoux,et al.  CXCR 4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses , 2016 .

[80]  M. Looney,et al.  Live imaging of the lung. , 2014, Annual review of physiology.

[81]  A. Mildner,et al.  A close encounter of the third kind: monocyte-derived cells. , 2013, Advances in immunology.

[82]  J. Casanova,et al.  Human CD 14 dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR 7 and TLR 8 Receptors , 2010 .

[83]  D. Rittirsch,et al.  Immunodesign of experimental sepsis by cecal ligation and puncture , 2008, Nature Protocols.