Magnetic resonance-guided near-infrared tomography of the breast

The design and implementation of a multispectral, frequency-domain near infrared tomography system is outlined, which operates in a MRI magnet for utilization of MR-guided image reconstruction of tissue optical properties. Using long silica optical fiber bundles, measurements of light transmission through up to 12 cm of female breast tissue can be acquired simultaneously with MRI scans. The NIR system utilizes six optical wavelengths from 660 to 850 nm using intensity modulated diode lasers nominally working at 100 MHz. Photomultiplier tube detector gain levels are electronically controlled on a time scale of 200 ms, thereby allowing rapid switching of the source to locations around the tissue. There are no moving parts in the detection channels and for each source position, 15 PMTs operating in parallel allow sensitivity down to 0.5 pW/cm2 at the tissue surface. Images of breast tissue optical absorption and reduced scattering coefficients are obtained using a Newton-type reconstruction algorithm to solv...

[1]  Harry L. Graber,et al.  MRI-guided optical tomography: prospects and computation for a new imaging method , 1995 .

[2]  B. Pogue,et al.  Three-dimensional optical tomography: resolution in small-object imaging. , 2003, Applied optics.

[3]  B. Pogue,et al.  Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast. , 2001, Radiology.

[4]  B. Pogue,et al.  Spatially variant regularization improves diffuse optical tomography. , 1999, Applied optics.

[5]  Brian W. Pogue,et al.  Near-infrared diffuse tomography combined with a priori MRI structural information: testing a hybrid image reconstruction methodology with functional imaging of the rat cranium , 1999, Photonics West - Biomedical Optics.

[6]  Dr. Andreas von Deimling.  Neoplasia , 1997, Laboratory investigation; a journal of technical methods and pathology.

[7]  Brian W. Pogue,et al.  Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Britton Chance,et al.  TIME-CORRELATED SINGLE PHOTON COUNTING IMAGER FOR SIMULTANEOUS MAGNETIC RESONANCE AND NEAR-INFRARED MAMMOGRAPHY , 1998 .

[9]  D. Boas,et al.  Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans. , 2004, Optics letters.

[10]  R Esposito,et al.  Depth dependence of the analytical expression for the width of the point spread function (spatial resolution) in time-resolved transillumination. , 2001, Journal of biomedical optics.

[11]  B. Pogue,et al.  A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the , 2001 .

[12]  N. Chen,et al.  Simultaneous near-infrared diffusive light and ultrasound imaging. , 2001, Applied optics.

[13]  S. Arridge.  Optical tomography in medical imaging , 1999 .

[14]  Britton Chance,et al.  Diffuse optical tomography of highly heterogeneous media , 2001, IEEE Transactions on Medical Imaging.

[15]  K. Paulsen,et al.  Spatially varying optical property reconstruction using a finite element diffusion equation approximation. , 1995, Medical physics.

[16]  M. Schweiger,et al.  Photon-measurement density functions. Part 2: Finite-element-method calculations. , 1995, Applied optics.

[17]  K D Paulsen,et al.  Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite-element image reconstruction. , 2001, Applied optics.

[18]  S R Arridge,et al.  Optical tomographic reconstruction in a complex head model using a priori region boundary information. , 1999, Physics in medicine and biology.

[19]  Brian W. Pogue,et al.  Near-infrared breast tomography calibration with optoelastic tissue simulating phantoms , 2003, J. Electronic Imaging.

[20]  B. Pogue,et al.  Comparisons of three alternative breast modalities in a common phantom imaging experiment. , 2003, Medical physics.

[21]  D. Lübbers,et al.  Oxygen transport to tissue--V , 1984 .

[22]  V. Ntziachristos,et al.  MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. , 2002, Neoplasia.

[23]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[24]  B. Pogue,et al.  Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results. , 2003, Applied optics.

[25]  Duane F. Bruley,et al.  Oxygen transport to tissue , 1973 .

[26]  Sandra K. Soho,et al.  Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. , 2004, Journal of biomedical optics.

[27]  A. Dale,et al.  Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging. , 2003, Applied optics.

[28]  E. Miller,et al.  Tomographic optical breast imaging guided by three-dimensional mammography. , 2003, Applied optics.

[29]  Quing Zhu,et al.  Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound. , 2003, Optics letters.

[30]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[31]  B. Pogue,et al.  Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities , 2003 .

[32]  Yuji Nakamoto,et al.  Fluorodeoxyglucose uptake in the aortic wall at PET/CT: possible finding for active atherosclerosis. , 2003, Radiology.

[33]  E. Miller,et al.  Efficient determination of multiple regularization parameters in a generalized L-curve framework , 2002 .

[34]  Bruce J. Tromberg,et al.  Congruent MRI and Near-infrared Spectroscopy for Functional and Structural Imaging of Tumors , 2002, Technology in cancer research & treatment.

[35]  Sabrina S Wilson.  Radiology , 1938, Glasgow Medical Journal.