Multiwalled Carbon Nanotubes Decorated with Fe3O4 Nanoparticles for Efficacious Doxycycline Delivery

Multiwalled carbon nanotubes (MWCNTs) based nanovectors have flourished when we furnish them with iron oxide (Fe3O4) nanoparticles (NPs) and an antibiotic, doxycycline (Doxy), as Doxy-MWCNTs/Fe3O4 conjugates. Doxycycline is a broad-spectrum antibiotic prescribed worldwide for treating a variety of infectious agents. However, limited drug bioavailability with unacceptable efficacy and safety profiles are the prime drawbacks of Doxy. To combat these pitfalls, we have employed and appraised the developed conjugates. Magnetic measurement studies have revealed superparamagnetic behavior of Fe3O4 NP-embellished MWCNTs. Successful loading of Doxy onto the Fe3O4 NP-embellished MWCNTs’ exterior have been imparted by transmission electron microscope image and Raman spectra. While Fourier transform-infrared and ultraviolet–visible spectrographs have corroborated composition and explored the probable mechanism of conjugation between Doxy and MWCNTs/Fe3O4. Zeta-potential studies demonstrated surface charges of constit...