An improved synthesis of 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic acid for photoaffinity labeling

An improved synthesis of 4- [3-(trifluoromethyl)-3H-diazirin-3 -yl] benzoic acid, a key carbene precursor for photoaffinity labeling, was described. A new diazirine with amino group as a connective part was designed