Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents.
暂无分享,去创建一个
J. Reynisson | I. Leung | E. Leung | D. Barker | Chatchakorn Eurtivong | L. Pilkington | Ivanhoe K. H. Leung | M. van Rensburg | H. Brar | Nabangshu Sharma | Emily K. Paulin | Reuben White | Shaun W P Rees | Chris Sun Xu
[1] J. Reynisson,et al. The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening , 2018, Molecular informatics.
[2] M. Takemoto,et al. A novel role of the antitumor agent tricyclodecan‐9‐yl‐xanthogenate as an open channel blocker of KCNQ1/KCNE1 , 2018, European journal of pharmacology.
[3] J. Reynisson,et al. Virtual screening and biophysical studies lead to HSP90 inhibitors. , 2017, Bioorganic & medicinal chemistry letters.
[4] O. Lavrik,et al. New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties. , 2016, Bioorganic & medicinal chemistry.
[5] M. E. Castelli,et al. High-level production of Bacillus cereus phospholipase C in Corynebacterium glutamicum. , 2015, Journal of biotechnology.
[6] M. Brimble,et al. Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation , 2015 .
[7] Tian Zhu,et al. Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis. , 2013, Journal of medicinal chemistry.
[8] D. Hwang,et al. Phospholipase signalling networks in cancer , 2012, Nature Reviews Cancer.
[9] Andreas Bender,et al. Recognizing Pitfalls in Virtual Screening: A Critical Review , 2012, J. Chem. Inf. Model..
[10] R. M. Adibhatla,et al. Tricyclodecan-9-yl-Xanthogenate (D609) Mechanism of Actions: A Mini-Review of Literature , 2012, Neurochemical Research.
[11] A. Molinari,et al. Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells , 2012, Breast Cancer Research.
[12] Yunde Zhao. Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants. , 2012, Molecular plant.
[13] Patricia González‐Bulnes,et al. 2-aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLC(Bc). , 2010, Bioorganic & medicinal chemistry.
[14] Dong-Seok Kim,et al. UVB-activated indole-3-acetic acid induces apoptosis of PC-3 prostate cancer cells. , 2010, Anticancer research.
[15] Yun Zhang,et al. Targeting phosphatidylcholine-specific phospholipase C for atherogenesis therapy. , 2010, Trends in cardiovascular medicine.
[16] M. Pisanu,et al. Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells , 2010, Breast Cancer Research.
[17] P. Workman,et al. The identification of novel PLC-gamma inhibitors using virtual high throughput screening. , 2009, Bioorganic & medicinal chemistry.
[18] Thomas Stützle,et al. Empirical Scoring Functions for Advanced Protein-Ligand Docking with PLANTS , 2009, J. Chem. Inf. Model..
[19] C. Carson,et al. Tadalafil in the treatment of erectile dysfunction , 2008, Therapeutics and clinical risk management.
[20] D. Gupta,et al. Virtual high throughput screening (vHTS) - A perspective , 2008, Bioinformation.
[21] S. Canevari,et al. Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells. , 2008, Cancer research.
[22] N. Goodey,et al. Structural studies examining the substrate specificity profiles of PC-PLC(Bc) protein variants. , 2006, Archives of biochemistry and biophysics.
[23] Kyoung-Chan Park,et al. Hydrogen peroxide is a mediator of indole‐3‐acetic acid/horseradish peroxidase‐induced apoptosis , 2006, FEBS letters.
[24] Marcel L Verdonk,et al. General and targeted statistical potentials for protein–ligand interactions , 2005, Proteins.
[25] D. Frank Hsu,et al. Consensus Scoring Criteria for Improving Enrichment in Virtual Screening , 2005, J. Chem. Inf. Model..
[26] Richard D. Taylor,et al. Improved protein–ligand docking using GOLD , 2003, Proteins.
[27] P. Wardman. Indole-3-acetic acids and horseradish peroxidase: a new prodrug/enzyme combination for targeted cancer therapy. , 2002, Current pharmaceutical design.
[28] Stephen R. Johnson,et al. Molecular properties that influence the oral bioavailability of drug candidates. , 2002, Journal of medicinal chemistry.
[29] Shaomeng Wang,et al. How Does Consensus Scoring Work for Virtual Library Screening? An Idealized Computer Experiment , 2001, J. Chem. Inf. Comput. Sci..
[30] J. Jaffrezou,et al. Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells. , 2000, The Biochemical journal.
[31] P. Hergenrother,et al. A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. , 2000, The Journal of organic chemistry.
[32] P. Hergenrother,et al. Catalytic cycle of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. Solvent viscosity, deuterium isotope effects, and proton inventory studies. , 1999, Biochemistry.
[33] G. V. Paolini,et al. Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes , 1997, J. Comput. Aided Mol. Des..
[34] M. Roberts,et al. Cloning, overexpression, refolding, and purification of the nonspecific phospholipase C from Bacillus cereus. , 1997, Protein expression and purification.
[35] Huili Chen,et al. CHANGES OF PHOSPHATIDYLCHOLINE‐SPECIFIC PHOSPHOLIPASE C IN HEPATOCARCINOGENESIS AND IN THE PROLIFERATION AND DIFFERENTIATION OF RAT LIVER CANCER CELLS , 1997, Cell biology international.
[36] P Willett,et al. Development and validation of a genetic algorithm for flexible docking. , 1997, Journal of molecular biology.
[37] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[38] S. Martin,et al. Design, Synthesis, and Evaluation of Phospholipid Analogs as Inhibitors of the Bacterial Phospholipase C from Bacillus cereus , 1994 .
[39] Marina Lasagni,et al. New molecular descriptors for 2D and 3D structures. Theory , 1994 .
[40] Edward Hough,et al. High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus , 1989, Nature.
[41] C. Little,et al. Increased arachidonic acid metabolites from cells in culture after treatment with the phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus. , 1987, Prostaglandins.
[42] J. Bomalaski,et al. Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phospholipase C in mammalian cells. , 1986, Biochemical and biophysical research communications.
[43] C. Little,et al. Inhibition of Bacillus cereus phospholipase C by univalent anions. , 1982, The Biochemical journal.
[44] C. Vines. Phospholipase C. , 2012, Advances in experimental medicine and biology.
[45] Tudor I. Oprea,et al. Compound collection preparation for virtual screening. , 2012, Methods in molecular biology.
[46] G. Oliva,et al. Virtual screening and its integration with modern drug design technologies. , 2008, Current medicinal chemistry.
[47] Kyoung-Chan Park,et al. Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. , 2004, Cellular signalling.
[48] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.
[49] T. N. Bhat,et al. The Protein Data Bank , 2000, Nucleic Acids Res..
[50] E. Amtmann. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. , 1996, Drugs under experimental and clinical research.