The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

[1]  Carol W. Greider,et al.  Telomere Dysfunction Increases Mutation Rate and Genomic Instability , 2001, Cell.

[2]  E. Blackburn,et al.  A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Margaret A. Strong,et al.  Telomere dysfunction triggers developmentally regulated germ cell apoptosis. , 2001, Molecular biology of the cell.

[4]  M. Cerone,et al.  Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability , 2001, Oncogene.

[5]  N. Marziliano,et al.  Pericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  D. Gottschling,et al.  The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku , 2001, Nature Genetics.

[7]  P. Finnon,et al.  Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals , 2000, The Journal of experimental medicine.

[8]  E. Blackburn,et al.  Telomere states and cell fates , 2000, Nature.

[9]  Peter M Lansdorp,et al.  Repair of telomeric DNA prior to replicative senescence , 2000, Mechanisms of Ageing and Development.

[10]  Elke Feldmann,et al.  DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining , 2000, Nucleic Acids Res..

[11]  C. Schmoor,et al.  Accumulation of short telomeres in human fibroblasts prior to replicative senescence. , 2000, Experimental Cell Research.

[12]  Heidi S. Liss,et al.  Subsenescent Telomere Lengths in Fibroblasts Immortalized by Limiting Amounts of Telomerase* , 2000, The Journal of Biological Chemistry.

[13]  M. Hemann,et al.  Telomere length, telomere-binding proteins, and DNA damage signaling. , 2000, Cold Spring Harbor symposia on quantitative biology.

[14]  L. Chin,et al.  Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation , 2000, Nature Genetics.

[15]  Lynda Chin,et al.  E.: “A Summary of , 1968 .

[16]  J. Griffith,et al.  Mammalian Telomeres End in a Large Duplex Loop , 1999, Cell.

[17]  E. Blackburn,et al.  Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[18]  D. Broccoli,et al.  p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. , 1999, Science.

[19]  M. Hande,et al.  Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice , 1999, The Journal of cell biology.

[20]  K. Kinzler,et al.  Genetic instabilities in human cancers , 1998, Nature.

[21]  P. Slijepcevic Telomeres and mechanisms of Robertsonian fusion , 1998, Chromosoma.

[22]  R. DePinho,et al.  Essential role of mouse telomerase in highly proliferative organs , 1998, Nature.

[23]  Robin C. Allshire,et al.  Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe , 1998, Nature.

[24]  Paul Nurse,et al.  Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination , 1998, Nature.

[25]  R. Ward,et al.  Short telomeres on human chromosome 17p. , 1998 .

[26]  R. Ward,et al.  Short telomeres on human chromosome 17p , 1998, Nature Genetics.

[27]  E. Blackburn,et al.  The telomere and telomerase: how do they interact? , 1999, Ciba Foundation symposium.

[28]  S. Bacchetti,et al.  Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability , 1997, Molecular and cellular biology.

[29]  María A Blasco,et al.  Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA , 1997, Cell.

[30]  D. Broccoli,et al.  Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2 , 1997, Nature Genetics.

[31]  J. Sedat,et al.  Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation , 1997, Science.

[32]  Bas van Steensel,et al.  Control of telomere length by the human telomeric protein TRF1 , 1997, Nature.

[33]  C B Harley,et al.  Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase , 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[34]  F. Ishikawa [Telomere and telomerase]. , 1996, Human Cell.

[35]  Thomas Ried,et al.  Multicolour spectral karyotyping of mouse chromosomes , 1996, Nature Genetics.

[36]  H. Tanke,et al.  Heterogeneity in telomere length of human chromosomes. , 1996, Human molecular genetics.

[37]  C. Greider,et al.  Telomere length regulation. , 1996, Annual review of biochemistry.

[38]  E. Blackburn,et al.  Runaway telomere elongation caused by telomerase RNA gene mutations , 1995, Nature.

[39]  T. Lange,et al.  Activation of telomerase in a human tumor. , 1994 .

[40]  T. de Lange Activation of telomerase in a human tumor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Haber,et al.  Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events , 1994, Molecular and cellular biology.

[42]  C B Harley,et al.  Telomere length predicts replicative capacity of human fibroblasts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[43]  B. Taylor,et al.  Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere. , 1991, Genomics.

[44]  D. Shore,et al.  Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length , 1990, Science.

[45]  E. Blackburn,et al.  Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Carol W. Greider,et al.  Identification of a specific telomere terminal transferase activity in tetrahymena extracts , 1985, Cell.

[47]  V. Chapman,et al.  Construction of a small Mus musculus repetitive DNA library: identification of a new satellite sequence in Mus musculus. , 1983, Nucleic acids research.

[48]  D C Ward,et al.  Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[49]  B. Mcclintock,et al.  The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion. , 1942, Proceedings of the National Academy of Sciences of the United States of America.

[50]  B. Mcclintock,et al.  The Stability of Broken Ends of Chromosomes in Zea Mays. , 1941, Genetics.

[51]  B. Mcclintock The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis. , 1939, Proceedings of the National Academy of Sciences of the United States of America.