From Optogenetic Technologies to Neuromodulation Therapies

Translating optogenetic technologies into the clinic will encounter a number of technical, practical, and regulatory hurdles. The field of optogenetics has provided new insight into neuronal communication and complex brain function. Now, scientists eagerly anticipate clinical application of this technology, with the hope that it will help improve treatments for various neurological disorders. However, the translational hurdles are high. In this Perspective, we highlight the technical, practical, and regulatory hurdles that lie ahead along the path towards making optogenetic neuromodulation therapies a reality in the clinic.

[1]  D. Fairclough,et al.  Discrepancies between patient and physician estimates for the success of stem cell transplantation. , 2001, JAMA.

[2]  Patrick Degenaar,et al.  Optobionic vision—a new genetically enhanced light on retinal prosthesis , 2009, Journal of neural engineering.

[3]  E. Racine,et al.  Preparing the ethical future of deep brain stimulation. , 2009, Surgical neurology.

[4]  Jacob G. Bernstein,et al.  Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain , 2009, Neuron.

[5]  Karl Deisseroth,et al.  Optogenetics in Neural Systems , 2011, Neuron.

[6]  P. Stypulkowski,et al.  Electrical stimulation as therapy for neurological disorders , 2006, IEEE Engineering in Medicine and Biology Magazine.

[7]  A. Abeliovich,et al.  Reprogramming Therapeutics: iPS Cell Prospects for Neurodegenerative Disease , 2009, Neuron.

[8]  T. Foltynie,et al.  Gene therapy: a viable therapeutic strategy for Parkinson’s disease? , 2011, Journal of Neurology.

[9]  Jo Wixon,et al.  Gene therapy clinical trials worldwide to 2007—an update , 2007, The journal of gene medicine.

[10]  Karl Deisseroth,et al.  Functional Control of Transplantable Human ESC‐Derived Neurons Via Optogenetic Targeting , 2010, Stem cells.

[11]  Murtaza Z Mogri,et al.  Optical Deconstruction of Parkinsonian Neural Circuitry , 2009, Science.

[12]  Ki-Soo Park,et al.  Neural stem cells – a versatile tool for cell replacement and gene therapy in the central nervous system , 1999, Clinical genetics.

[13]  Edward S Boyden,et al.  Optogenetics and Translational Medicine , 2013, Science Translational Medicine.

[14]  R. Normann,et al.  Thermal Impact of an Active 3-D Microelectrode Array Implanted in the Brain , 2007, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[15]  Timothy Denison,et al.  An Implantable Optical Stimulation Delivery System for Actuating an Excitable Biosubstrate , 2011, IEEE Journal of Solid-State Circuits.