Hemolysin of enterohemorrhagic Escherichia coli: structure, transport, biological activity and putative role in virulence.

[1]  Lindsay S. Keir Shiga toxin associated hemolytic uremic syndrome. , 2015, Hematology/oncology clinics of North America.

[2]  Surveillance Protocol Shiga toxin-producing Escherichia coli (STEC) , 2015 .

[3]  L. Siegfried,et al.  [Cytolethal distending toxins]. , 2014, Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne.

[4]  Christine A. Pellino Characterization of Shiga Toxin Potency and Assembly , 2014 .

[5]  A. Mellmann,et al.  Enterohemorrhagic Escherichia coli Hemolysin Employs Outer Membrane Vesicles to Target Mitochondria and Cause Endothelial and Epithelial Apoptosis , 2013, PLoS pathogens.

[6]  M. Fischer,et al.  Prevalence of Hemolysin Genes and Comparison of ehxA Subtype Patterns in Shiga Toxin-Producing Escherichia coli (STEC) and Non-STEC Strains from Clinical, Food, and Animal Sources , 2013, Applied and Environmental Microbiology.

[7]  T. J. Wiles,et al.  The RTX pore-forming toxin α-hemolysin of uropathogenic Escherichia coli: progress and perspectives. , 2013, Future microbiology.

[8]  Hui Sun,et al.  Enterohemorrhagic Escherichia coli Specific Enterohemolysin Induced IL-1β in Human Macrophages and EHEC-Induced IL-1β Required Activation of NLRP3 Inflammasome , 2012, PloS one.

[9]  P. Fratamico,et al.  DNA sequence and analysis of a 90.1-kb plasmid in Shiga toxin-producing Escherichia coli (STEC) O145:NM 83-75. , 2012, Plasmid.

[10]  J. Terajima,et al.  Coordinate Control of the Locus of Enterocyte Effacement and Enterohemolysin Genes by Multiple Common Virulence Regulators in Enterohemorrhagic Escherichia coli , 2011, Infection and Immunity.

[11]  H. Karch,et al.  Enterohaemorrhagic Escherichia coli haemolysin is cleaved and inactivated by serine protease EspPα , 2011, Environmental microbiology.

[12]  P. Fratamico,et al.  The complete DNA sequence and analysis of the virulence plasmid and of five additional plasmids carried by Shiga toxin-producing Escherichia coli O26:H11 strain H30. , 2011, International journal of medical microbiology : IJMM.

[13]  Patrik Langehanenberg,et al.  Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells , 2010, Thrombosis and Haemostasis.

[14]  T. Obrig Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease , 2010, Toxins.

[15]  I. Linhartova,et al.  RTX proteins: a highly diverse family secreted by a common mechanism , 2010, FEMS microbiology reviews.

[16]  M. Kuehn,et al.  Biological functions and biogenesis of secreted bacterial outer membrane vesicles. , 2010, Annual review of microbiology.

[17]  S. Johnson,et al.  Pathophysiology of typical hemolytic uremic syndrome. , 2010, Seminars in thrombosis and hemostasis.

[18]  C. Czuprynski,et al.  N‐terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells , 2010, Cellular microbiology.

[19]  K. Irino,et al.  Set of virulence genes and genetic relatedness of O113 : H21 Escherichia coli strains isolated from the animal reservoir and human infections in Brazil. , 2010, Journal of medical microbiology.

[20]  M. Morigi,et al.  Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction , 2010, Pediatric Nephrology.

[21]  T. Whittam,et al.  Increased Adherence and Expression of Virulence Genes in a Lineage of Escherichia coli O157:H7 Commonly Associated with Human Infections , 2010, PloS one.

[22]  M. Kuehn,et al.  Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles , 2010, Microbiology and Molecular Biology Reviews.

[23]  B. Kemper,et al.  Vacuolisation of human microvascular endothelial cells by enterohaemorrhagic Escherichia coli , 2009, Thrombosis and Haemostasis.

[24]  M. Scott,et al.  Histone-like nucleoid-structuring protein represses transcription of the ehx operon carried by locus of enterocyte effacement-negative Shiga toxin-expressing Escherichia coli. , 2009, Microbial pathogenesis.

[25]  M. Morais,et al.  Evidence of Pathogenic Subgroups among Atypical Enteropathogenic Escherichia coli Strains , 2009, Journal of Clinical Microbiology.

[26]  A. Fruth,et al.  Molecular Analysis of Virulence Profiles and Shiga Toxin Genes in Food-Borne Shiga Toxin-Producing Escherichia coli , 2009, Applied and Environmental Microbiology.

[27]  L. Bakas,et al.  Relevance of Fatty Acid Covalently Bound to Escherichia coli α-Hemolysin and Membrane Microdomains in the Oligomerization Process* , 2009, The Journal of Biological Chemistry.

[28]  T. Whittam,et al.  Characterisation of atypical enteropathogenic E. coli strains of clinical origin , 2009, BMC Microbiology.

[29]  A. Mellmann,et al.  Intrahost genome alterations in enterohemorrhagic Escherichia coli. , 2009, Gastroenterology.

[30]  A. Mellmann,et al.  Shiga Toxin, Cytolethal Distending Toxin, and Hemolysin Repertoires in Clinical Escherichia coli O91 Isolates , 2009, Journal of Clinical Microbiology.

[31]  H. Karch,et al.  Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin , 2009, Molecular microbiology.

[32]  T. Whittam,et al.  Shiga Toxin–producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement , 2009, Emerging Infectious Diseases.

[33]  J. Gillespie,et al.  RpoS, H-NS, and DsrA influence EHEC hemolysin operon (ehxCABD) transcription in Escherichia coli O157:H7 strain EDL933. , 2008, FEMS microbiology letters.

[34]  A. Mellmann,et al.  Shiga toxin-negative attaching and effacing Escherichia coli: distinct clinical associations with bacterial phylogeny and virulence traits and inferred in-host pathogen evolution. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[35]  J. Terajima,et al.  Transcription of the ehx Enterohemolysin Gene Is Positively Regulated by GrlA, a Global Regulator Encoded within the Locus of Enterocyte Effacement in Enterohemorrhagic Escherichia coli , 2008, Journal of bacteriology.

[36]  T. Besser,et al.  Associations between bovine, human, and raw milk, and beef isolates of non-O157 Shiga toxigenic Escherichia coli within a restricted geographic area of the United States. , 2008, Journal of food protection.

[37]  A. Mellmann,et al.  Analysis of Collection of Hemolytic Uremic Syndrome- Enterohemorrhagic Escherichia coli , 2008 .

[38]  A. Mellmann,et al.  Shiga Toxin-Mediated Hemolytic Uremic Syndrome: Time to Change the Diagnostic Paradigm? , 2007, PloS one.

[39]  G. Attwood,et al.  Molecular Subtyping and Genetic Analysis of the Enterohemolysin Gene (ehxA) from Shiga Toxin-Producing Escherichia coli and Atypical Enteropathogenic E. coli , 2007, Applied and Environmental Microbiology.

[40]  A. Mellmann,et al.  Subtypes of the Plasmid-Encoded Serine Protease EspP in Shiga Toxin-Producing Escherichia coli: Distribution, Secretion, and Proteolytic Activity , 2007, Applied and Environmental Microbiology.

[41]  H. Karch,et al.  Identification of Unconventional Intestinal Pathogenic Escherichia coli Isolates Expressing Intermediate Virulence Factor Profiles by Using a Novel Single-Step Multiplex PCR , 2007, Applied and Environmental Microbiology.

[42]  A. Friedrich,et al.  Hemolysin from Shiga toxin-negative Escherichia coli O26 strains injures microvascular endothelium. , 2007, Microbes and infection.

[43]  A. Mellmann,et al.  Structural and functional differences between disease-associated genes of enterohaemorrhagic Escherichia coli O111. , 2007, International journal of medical microbiology : IJMM.

[44]  H. Karch,et al.  Complete sequence of the large virulence plasmid pSFO157 of the sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H- strain 3072/96. , 2006, International journal of medical microbiology : IJMM.

[45]  L. Beutin,et al.  Dissemination and persistence of Shiga toxin-producing Escherichia coli (STEC) strains on French dairy farms. , 2006, Veterinary microbiology.

[46]  J. Harel,et al.  Identification of Virulence Genes Linked with Diarrhea Due to Atypical Enteropathogenic Escherichia coli by DNA Microarray Analysis and PCR , 2006, Journal of Clinical Microbiology.

[47]  A. Siitonen,et al.  Molecular and phenotypic profiling of sorbitol-fermenting Escherichia coli O157:H- human isolates from Finland. , 2006, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[48]  T. Besser,et al.  Expression of Putative Virulence Factors of Escherichia coli O157:H7 Differs in Bovine and Human Infections , 2006, Infection and Immunity.

[49]  A. Friedrich,et al.  Cytolethal Distending Toxin in Escherichia coli O157:H7: Spectrum of Conservation, Structure, and Endothelial Toxicity , 2006, Journal of Clinical Microbiology.

[50]  A. Friedrich,et al.  New aspects in the pathogenesis of enteropathic hemolytic uremic syndrome. , 2006, Seminars in thrombosis and hemostasis.

[51]  S. Wai,et al.  Release of the type I secreted α‐haemolysin via outer membrane vesicles from Escherichia coli , 2006 .

[52]  B. Finlay,et al.  A Positive Regulatory Loop Controls Expression of the Locus of Enterocyte Effacement-Encoded Regulators Ler and GrlA , 2005, Journal of bacteriology.

[53]  H. Karch,et al.  Enterohaemorrhagic Escherichia coli in human medicine. , 2005, International journal of medical microbiology : IJMM.

[54]  A. Mellmann,et al.  Enterohemorrhagic Escherichia coli in human infection: in vivo evolution of a bacterial pathogen. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[55]  C. Czuprynski,et al.  Mannheimia haemolytica Leukotoxin Induces Apoptosis of Bovine Lymphoblastoid Cells (BL-3) via a Caspase-9-Dependent Mitochondrial Pathway , 2005, Infection and Immunity.

[56]  H. Karch,et al.  Consequences of enterohaemorrhagic Escherichia coli infection for the vascular endothelium , 2005, Thrombosis and Haemostasis.

[57]  P. Tarr,et al.  Shiga-toxin-producing and haemolytic uraemic syndrome , 2005 .

[58]  P. Tarr,et al.  Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome , 2005, The Lancet.

[59]  M. Blanco,et al.  Phenotypic and genotypic characteristics of non-O157 Shiga toxin-producing Escherichia coli (STEC) from Swiss cattle. , 2005, Veterinary microbiology.

[60]  H. Karch,et al.  Cytolethal Distending Toxin from Shiga Toxin-Producing Escherichia coli O157 Causes Irreversible G2/M Arrest, Inhibition of Proliferation, and Death of Human Endothelial Cells , 2005, Infection and Immunity.

[61]  Lutz Schmitt,et al.  Type 1 protein secretion in bacteria, the ABC-transporter dependent pathway (Review) , 2005, Molecular membrane biology.

[62]  P. Srimanote,et al.  A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli , 2004, The Journal of experimental medicine.

[63]  C. Dorman H-NS: a universal regulator for a dynamic genome , 2004, Nature Reviews Microbiology.

[64]  L. Beutin,et al.  Characterization of Shiga Toxin-Producing Escherichia coli Strains Isolated from Human Patients in Germany over a 3-Year Period , 2004, Journal of Clinical Microbiology.

[65]  H. Karch,et al.  Phenotypic and Genotypic Analyses of Enterohemorrhagic Escherichia coli O145 Strains from Patients in Germany , 2004, Journal of Clinical Microbiology.

[66]  M. Karmali Infection by shiga toxin-producing Escherichia coli , 2004, Molecular biotechnology.

[67]  W. Goebel,et al.  Oligomerization of Escherichia coli haemolysin (HlyA) is involved in pore formation , 1993, Molecular and General Genetics MGG.

[68]  W. Goebel,et al.  The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytes , 1988, Molecular and General Genetics MGG.

[69]  Denisse L. Leyton,et al.  Transfer Region of pO113 from Enterohemorrhagic Escherichia coli: Similarity with R64 and Identification of a Novel Plasmid-Encoded Autotransporter, EpeA , 2003, Infection and Immunity.

[70]  F. Goñi,et al.  Asp‐863 is a key residue for calcium‐dependent activity of Escherichia coli RTX toxin α‐haemolysin , 2003, FEBS letters.

[71]  A. Friedrich,et al.  Shiga Toxin 1c-Producing Escherichia coli Strains: Phenotypic and Genetic Characterization and Association with Human Disease , 2003, Journal of Clinical Microbiology.

[72]  I. Chinen,et al.  Serotypes and Shiga toxin genotypes among Escherichia coli isolated from animals and food in Argentina and Brazil. , 2003, Veterinary microbiology.

[73]  M. Scott,et al.  Mutations in hns reduce the adherence of Shiga toxin-producing E. coli 091:H21 strain B2F1 to human colonic epithelial cells and increase the production of hemolysin. , 2003, Microbial pathogenesis.

[74]  Tetsuya Hayashi,et al.  Escherichia coli , 1983, CABI Compendium.

[75]  A. Aperia,et al.  Dual effects of Escherichia coliα-hemolysin on rat renal proximal tubule cells , 2002 .

[76]  C. Gualerzi,et al.  Temperature- and H-NS-Dependent Regulation of a Plasmid-Encoded Virulence Operon Expressing Escherichia coli Hemolysin , 2002, Journal of bacteriology.

[77]  R. Hengge-aronis,et al.  Signal Transduction and Regulatory Mechanisms Involved in Control of the σS (RpoS) Subunit of RNA Polymerase , 2002, Microbiology and Molecular Biology Reviews.

[78]  Tatsuo Yamamoto,et al.  Enterohemolysin operon of Shiga toxin‐producing Escherichia coli: a virulence function of inflammatory cytokine production from human monocytes , 2002, FEBS letters.

[79]  F. Goñi,et al.  His-859 Is an Essential Residue for the Activity and pH Dependence of Escherichia coli RTX Toxin α-Hemolysin* , 2002, The Journal of Biological Chemistry.

[80]  L. Trabulsi,et al.  10.321/eid0805.Typical and Atypical Enteropathogenic Escherichia coli , 2002, Emerging infectious diseases.

[81]  Jianguo Xu,et al.  [Serological investigations on patients with hemolytic uremic syndromes due to enterohemorrhagic Escherichia coli O157:H7 infection]. , 2002, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.

[82]  P. Kuhnert,et al.  RTX toxins in Pasteurellaceae. , 2002, International journal of medical microbiology : IJMM.

[83]  L. Beutin,et al.  The bacteriophage-associated ehly1 and ehly2 determinants from Escherichia coli O26:H- strains do not encode enterohemolysins per se but cause release of the ClyA cytolysin. , 2002, International journal of medical microbiology : IJMM.

[84]  P. Srimanote,et al.  Characterization of Saa, a Novel Autoagglutinating Adhesin Produced by Locus of Enterocyte Effacement-Negative Shiga-ToxigenicEscherichia coli Strains That Are Virulent for Humans , 2001, Infection and Immunity.

[85]  Getting ADC to paediatricians in developing countries , 2001, Archives of disease in childhood.

[86]  S. Djordjevic,et al.  The detection of Shiga toxin-producing Escherichia coli in diagnostic bovine faecal samples using vancomycin-cefixime-cefsulodin blood agar and PCR. , 2001, FEMS microbiology letters.

[87]  S. Bhakdi,et al.  Interaction of Escherichia coli hemolysin with biological membranes. A study using cysteine scanning mutagenesis. , 2001, European journal of biochemistry.

[88]  L. Trabulsi,et al.  10.321/eid0805.Typical and Atypical Enteropathogenic Escherichia coli , 2002, Emerging infectious diseases.

[89]  R. Welch,et al.  RTX toxin structure and function: a story of numerous anomalies and few analogies in toxin biology. , 2001, Current topics in microbiology and immunology.

[90]  J. Samuel,et al.  Interaction of Shiga toxins with human brain microvascular endothelial cells: cytokines as sensitizing agents. , 1999, The Journal of infectious diseases.

[91]  J. Lanser,et al.  Molecular Characterization of a Shiga ToxigenicEscherichia coli O113:H21 Strain Lacking eaeResponsible for a Cluster of Cases of Hemolytic-Uremic Syndrome , 1999, Journal of Clinical Microbiology.

[92]  R B Hill,et al.  The interaction between RTX toxins and target cells. , 1999, Trends in microbiology.

[93]  T. Beveridge Structures of Gram-Negative Cell Walls and Their Derived Membrane Vesicles , 1999, Journal of bacteriology.

[94]  S. McEwen,et al.  Associations between Virulence Factors of Shiga Toxin-ProducingEscherichia coli and Disease in Humans , 1999, Journal of Clinical Microbiology.

[95]  H. Karch,et al.  Non-O157:H7 pathogenic Shiga toxin-producing Escherichia coli: phenotypic and genetic profiling of virulence traits and evidence for clonality. , 1999, The Journal of infectious diseases.

[96]  Jian Fei Wang,et al.  Actinobacillus actinomycetemcomitansLeukotoxin Induces Apoptosis in HL-60 Cells , 1998, Infection and Immunity.

[97]  Guy Plunkett,et al.  The complete DNA sequence and analysis of the large virulence plasmid of Escherichia coli O157:H7. , 1998, Nucleic acids research.

[98]  J. Colbourne,et al.  Evolution of Enterohemorrhagic Escherichia coli Hemolysin Plasmids and the Locus for Enterocyte Effacement in Shiga Toxin-Producing E. coli , 1998, Infection and Immunity.

[99]  P. Stanley,et al.  Acylation of Escherichia coli Hemolysin: A Unique Protein Lipidation Mechanism Underlying Toxin Function , 1998, Microbiology and Molecular Biology Reviews.

[100]  Jian Fei Wang,et al.  RTX Toxins Recognize a β2 Integrin on the Surface of Human Target Cells* , 1997, The Journal of Biological Chemistry.

[101]  F. D. Del Castillo,et al.  The Escherichia coli K‐12 sheA gene encodes a 34‐kDa secreted haemolysin , 1997, Molecular microbiology.

[102]  Y. Takeda Enterohaemorrhagic Escherichia coli. , 1997, World health statistics quarterly. Rapport trimestriel de statistiques sanitaires mondiales.

[103]  R. Welch,et al.  Association of RTX toxins with erythrocytes , 1996, Infection and immunity.

[104]  H. Karch,et al.  Enterohemolytic phenotypes and genotypes of shiga toxin-producing Escherichia coli O111 strains from patients with diarrhea and hemolytic-uremic syndrome , 1996, Journal of clinical microbiology.

[105]  R. Benz,et al.  Pore-forming properties of the plasmid-encoded hemolysin of enterohemorrhagic Escherichia coli O157:H7. , 1996, European journal of biochemistry.

[106]  H. Karch,et al.  Analysis of the EHEC hly operon and its location in the physical map of the large plasmid of enterohaemorrhagic Escherichia coli O157:h7. , 1996, Microbiology.

[107]  R. Welch,et al.  Characterization of an RTX toxin from enterohemorrhagic Escherichia coli O157:H7 , 1996, Infection and immunity.

[108]  R. Welch,et al.  Biological effects of RTX toxins: the possible role of lipopolysaccharide. , 1995, Trends in microbiology.

[109]  R. Welch,et al.  Battling against host phagocytes: the wherefore of the RTX family of toxins? , 1995, Infectious agents and disease.

[110]  S. Gottesman,et al.  A small RNA acts as an antisilencer of the H-NS-silenced rcsA gene of Escherichia coli. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[111]  L. Beutin,et al.  Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933 , 1995, Infection and immunity.

[112]  P. Stanley,et al.  Fatty acylation of two internal lysine residues required for the toxic activity of Escherichia coli hemolysin. , 1994, Science.

[113]  L. Beutin,et al.  The large-sized plasmids of enterohemorrhagic Escherichia coli O157 strains encode hemolysins which are presumably members of the E. coli alpha-hemolysin family. , 1994, FEMS microbiology letters.

[114]  L. Beutin,et al.  Characterization and sequence of a 33-kDa enterohemolysin (Ehly 1)-associated protein in Escherichia coli. , 1993, Gene.

[115]  L. Beutin,et al.  Isolation of enterohemolysin (Ehly2)-associated sequences encoded on temperate phages of Escherichia coli. , 1993, Gene.

[116]  V. V. van Hinsbergh,et al.  Tumor necrosis factor and interleukin-1 induce expression of the verocytotoxin receptor globotriaosylceramide on human endothelial cells: implications for the pathogenesis of the hemolytic uremic syndrome. , 1992, Blood.

[117]  J. Issartel,et al.  Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation , 1991, Nature.

[118]  M. Ozel,et al.  Enterohemolysin production is associated with a temperate bacteriophage in Escherichia coli serogroup O26 strains , 1990, Journal of bacteriology.

[119]  W. Seeger,et al.  Effects of Escherichia coli hemolysin on endothelial cell function , 1990, Infection and immunity.

[120]  S. Bhakdi,et al.  Effects of Escherichia coli hemolysin on human monocytes. Cytocidal action and stimulation of interleukin 1 release. , 1990, The Journal of clinical investigation.

[121]  L. Beutin,et al.  Close association of verotoxin (Shiga-like toxin) production with enterohemolysin production in strains of Escherichia coli , 1989, Journal of clinical microbiology.

[122]  S. Bhakdi,et al.  Potent leukocidal action of Escherichia coli hemolysin mediated by permeabilization of target cell membranes , 1989, The Journal of experimental medicine.

[123]  L. Becker,et al.  The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections. , 1988, Human pathology.

[124]  R. Welch,et al.  Transcriptional organization of the Escherichia coli hemolysin genes , 1988, Journal of bacteriology.

[125]  L. Beutin,et al.  Enterohemolysin, a new type of hemolysin produced by some strains of enteropathogenic E. coli (EPEC). , 1988, Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology.

[126]  N. Mackman,et al.  Escherichia coli hemolysin may damage target cell membranes by generating transmembrane pores , 1986, Infection and immunity.

[127]  W. Goebel,et al.  Transport of hemolysin across the outer membrane of Escherichia coli requires two functions , 1983, Journal of bacteriology.

[128]  W. Goebel,et al.  Cloning and functional characterization of the plasmid-encoded hemolysin determinant of Escherichia coli , 1982, Journal of bacteriology.

[129]  W. Kunicki-Goldfinger,et al.  [Escherichia coli hemolysins]. , 1955, Acta microbiologica Polonica.