Cell cycle phase dependent productivity of a recombinant Chinese hamster ovary cell line

[1]  Mohamed Al-Rubeai,et al.  Flow Cytometry Applications in Cell Culture , 2020 .

[2]  S. Sharfstein,et al.  Hyperosmotic Stress in Murine Hybridoma Cells: Effects on Antibody Transcription, Translation, Posttranslational Processing, and the Cell Cycle , 2008, Biotechnology progress.

[3]  P. Bork,et al.  Co-evolution of transcriptional and post-translational cell-cycle regulation , 2006, Nature.

[4]  Gavin Sherlock,et al.  Cell cycle: Complex evolution , 2006, Nature.

[5]  C. Smales,et al.  The cold-shock response in cultured mammalian cells: harnessing the response for the improvement of recombinant protein production. , 2006, Biotechnology and bioengineering.

[6]  Jussi Taipale,et al.  Identification of pathways regulating cell size and cell-cycle progression by RNAi , 2006, Nature.

[7]  S. R. Fox,et al.  A detailed understanding of the enhanced hypothermic productivity of interferon‐γ by Chinese‐hamster ovary cells , 2005, Biotechnology and applied biochemistry.

[8]  Kelvin H Lee,et al.  Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells. , 2005, Biotechnology and bioengineering.

[9]  Gyun Min Lee,et al.  Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 degrees C. , 2005, Biotechnology and bioengineering.

[10]  Gyun Min Lee,et al.  Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells. , 2003, Biotechnology and bioengineering.

[11]  W. Miller,et al.  Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: intracellular pH, cell size, apoptosis, and metabolism. , 2002, Biotechnology and bioengineering.

[12]  F. Gòdia,et al.  Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control. , 2001, Biotechnology and bioengineering.

[13]  G. Kretzmer,et al.  Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: a cell cycle phases analysis , 2001, Cytotechnology.

[14]  C. Hoy,et al.  Multiple cell culture factors can affect the glycosylation of Asn-184 in CHO-produced tissue-type plasminogen activator. , 2000, Biotechnology and bioengineering.

[15]  Mohamed Al-Rubeai,et al.  Relationship between cell size, cell cycle and specific recombinant protein productivity , 2000, Cytotechnology.

[16]  Sugiyono,et al.  Regulated autocrine growth of CHO cells , 2000, Cytotechnology.

[17]  J. Piret,et al.  Limitations to the amplification and stability of human tissue-type plasminogen activator expression by Chinese hamster ovary cells. , 2000, Biotechnology and bioengineering.

[18]  T. Warner.  Enhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting. , 1999, Glycobiology.

[19]  M. Al‐Rubeai,et al.  Use of cell cycle analysis to characterise growth and interferon-γ production in perfusion culture of CHO cells , 1999, Cytotechnology.

[20]  J E Bailey,et al.  Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells. , 1999, Biotechnology and bioengineering.

[21]  Jeno M. Scharer,et al.  Descriptive parameter evaluation in mammalian cell culture , 1998, Cytotechnology.

[22]  M. Fussenegger,et al.  A novel cytostatic process enhances the productivity of Chinese hamster ovary cells. , 1997, Biotechnology and bioengineering.

[23]  N. Toyoda,et al.  Changes in ovarian expression of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 messenger ribonucleic acids during ovulation in rat. , 1997, Endocrine journal.

[24]  D. James,et al.  Posttranslational processing of recombinant human interferon‐γ in animal expression systems , 1996, Protein science : a publication of the Protein Society.

[25]  T. Cartwright.  Animal cells as bioreactors: References , 1994 .

[26]  Z. Darżynkiewicz,et al.  CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo , 1994, European journal of immunology.

[27]  M. Gu,et al.  Foreign gene expression (β‐galactosidase) during the cell cycle phases in recombinant CHO cells , 1993, Biotechnology and bioengineering.

[28]  A. Bull,et al.  The effect of the dilution rate on CHO cell physiology and recombinant interferon‐γ production in glucose‐limited chemostat culture , 1993, Biotechnology and bioengineering.

[29]  E. Papoutsakis,et al.  Damaging agitation intensities increase DNA synthesis rate and alter cell‐cycle phase distributions of CHO cells , 1992, Biotechnology and bioengineering.

[30]  M S Croughan,et al.  Reversible removal and hydrodynamic phenomena in CHO microcarrier cultures. , 1990, Biotechnology and bioengineering.

[31]  H. Stockinger,et al.  Cell cycle-dependent DHFR and t-PA production in cotransfected, MTX-amplified CHO cells revealed by dual-laser flow cytometry. , 1990, Experimental cell research.

[32]  F. Castellino,et al.  Appearance of plasminogen activator activity during a synchronous cycle of a rat adenocarcinoma cell line, PA-III. , 1987, Experimental cell research.

[33]  G. Stein,et al.  Recombinant DNA and Cell Proliferation , 1984 .

[34]  A J Sinskey,et al.  Large‐scale Production of Mammalian Cells and Their Products: Engineering Principles and Barriers to Scale‐up , 1983, Annals of the New York Academy of Sciences.

[35]  Z. Werb,et al.  Regulation of protein secretion in Chinese hamster ovary cells by cell cycle position and cell density. Plasminogen activator, procollagen fibronectin. , 1982, Experimental cell research.

[36]  R. Schimke,et al.  S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D. Loskutoff,et al.  Intracellular plasminogen activator activity in growing and quiescent cells , 1978, Journal of cellular physiology.

[38]  J. Bertino,et al.  Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter. , 1978, The Journal of biological chemistry.

[39]  John Paul,et al.  Tissue culture: Methods and applications: Ed. by Paul F. Kruse, Jr and M. K. Patterson, Jr. 1973. New York and London: Academic Press. Pp. xxvii and 868; 264 text figs. £10.15. , 1974 .

[40]  J. Smith,et al.  Do cells cycle? , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. Kimble,et al.  Cell cycle-dependent expression of the CHO2 antigen, a minus-end directed kinesin-like motor in mammalian cells , 2005, Protoplasma.

[42]  D. Kompala,et al.  Foreign protein expression from S phase specific promoters in continuous cultures of recombinant CHO cells , 2004, Cytotechnology.

[43]  I. Chevalot,et al.  Production of a membrane-bound proteins, the human gamma-glutamyl transferase, by CHO cells cultivated on microcarriers, in aggregates and in suspension , 2004, Cytotechnology.

[44]  P. Gray,et al.  Enhanced productivity of G1 phase Chinese hamster ovary cells using the GADD153 promoter , 2004, Biotechnology Letters.

[45]  Mohamed Al-Rubeai,et al.  Modulation of Cell Cycle for Enhancement of Antibody Productivity in Perfusion Culture of NS0 Cells , 2003, Biotechnology progress.

[46]  Sónia Sá Santos,et al.  Cell Growth Arrest by Nucleotides, Nucleosides and Bases as a Tool for Improved Production of Recombinant Proteins , 2003, Biotechnology progress.

[47]  G Stephanopoulos,et al.  Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. , 2001, Biotechnology and bioengineering.

[48]  M. Moo-young,et al.  Hybridoma growth and productivity: effects of conditioned medium and of inoculum size , 1999, Cytotechnology.

[49]  S. Ueda,et al.  Recombinant porcine follicle stimulating hormone produced in baculovirus-insect cells induces rat ovulation in vivo and gene expression of tissue plasminogen activator in vitro. , 1998, Research in veterinary science.

[50]  J. Scharer,et al.  Thickness shear mode acoustic assay for plasminogen activators , 1998 .

[51]  Y. Chisti,et al.  Tissue-type plasminogen activator: characteristics, applications and production technology. , 1996, Biotechnology advances.

[52]  M. Tuite,et al.  Protein folding in the secretory pathway of animal cells. , 1995 .

[53]  Y. Assaraf,et al.  Characterization by flow cytometry of fluorescein-methotrexate transport in Chinese hamster ovary cells. , 1989, Cytometry.

[54]  L. Johnson.  2 – Expression of Dihydrofolate Reductase and Thymidylate Synthase Genes in Mammalian Cells , 1984 .

[55]  H. J. Phillips.  Dye Exclusion Tests for Cell Viability , 1973 .