Validation of an Insulin Infusion Nomogram for Intensive Glucose Control in Critically Ill Patients

Study Objective. To evaluate the effectiveness, safety, and associated patient outcomes of a simplified, nurse‐directed insulin nomogram designed to achieve intensive blood glucose level control (target range 90–144 mg/dl).

[1]  James D Dziura,et al.  Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit. , 2004, Diabetes care.

[2]  W. Lanier,et al.  Glucose modulation of ischemic brain injury: review and clinical recommendations. , 1996, Mayo Clinic proceedings.

[3]  E. Ohman,et al.  Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. , 2001, Chest.

[4]  P. Dodek,et al.  Intravenous insulin nomogram improves blood glucose control in the critically ill , 2001, Critical care medicine.

[5]  Miet Schetz,et al.  Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control* , 2003, Critical care medicine.

[6]  K. Alberti,et al.  Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST). , 1999, Stroke.

[7]  K. Jablonski,et al.  Unrecognized Diabetes Among Hospitalized Patients , 1998, Diabetes Care.

[8]  J Herlitz,et al.  Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. , 1995, Journal of the American College of Cardiology.

[9]  M. Mlynarek,et al.  An Insulin Infusion Protocol in Critically Ill Cardiothoracic Surgery Patients , 2004, The Annals of pharmacotherapy.

[10]  P. Kochanek,et al.  Promising strategies to minimize secondary brain injury after head trauma , 2003, Critical care medicine.

[11]  G. Grunkemeier,et al.  Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. , 2003, The Journal of thoracic and cardiovascular surgery.

[12]  A. Malhotra,et al.  Stress-induced hyperglycemia. , 2001, Critical care clinics.

[13]  B. Bistrian,et al.  Intensive insulin therapy in critically ill patients. , 2002, The New England journal of medicine.

[14]  A. M. J. Woolfson,et al.  Control of blood glucose during nutritional support in Ill patients , 2005, Intensive Care Medicine.

[15]  Salmaan Kanji,et al.  Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adults , 2004, Intensive Care Medicine.