Plumbagin binds to epidermal growth factor receptor and mitigate the effects of epidermal growth factor micro-environment in PANC-1 cells

[1]  Sridhar Muthusami,et al.  Screening of MMP-2 Inhibiting Phytoconstituents for The Development of Newer Pancreatic Cancer Modalities. , 2023, Protein and peptide letters.

[2]  W. Park,et al.  Phyto-targeting the CEMIP expression as a strategy to prevent pancreatic cancer metastasis. , 2022, Current pharmaceutical design.

[3]  M. Maak,et al.  Pankreaskarzinom , 2021, Therapeutische Umschau.

[4]  W. Park,et al.  A review on the role of epidermal growth factor signaling in the development, progression and treatment of cervical cancer. , 2021, International journal of biological macromolecules.

[5]  T. Pawlik Pancreatic Cancer. , 2021, Surgical oncology clinics of North America.

[6]  J. Devar,et al.  Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance , 2021, Frontiers in Oncology.

[7]  J. Mecklin,et al.  Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer , 2021, Scientific Reports.

[8]  P. Saha,et al.  Downregulation of Hyaluronic acid-CD44 signaling pathway in cervical cancer cell by natural polyphenols Plumbagin, Pongapin and Karanjin , 2021, Molecular and Cellular Biochemistry.

[9]  Y. Yarden,et al.  EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance , 2021, Cancers.

[10]  G. Balasubramaniam,et al.  An epidemiological review of pancreatic cancer with special reference to India , 2021 .

[11]  Sridhar Muthusami,et al.  Acetogenin Extracted from Annona muricata Prevented the Actions of EGF in PA-1 Ovarian Cancer Cells. , 2020, Protein and peptide letters.

[12]  B. Biswal,et al.  Prooxidative activity of plumbagin induces apoptosis in human pancreatic ductal adenocarcinoma cells via intrinsic apoptotic pathway. , 2020, Toxicology in vitro : an international journal published in association with BIBRA.

[13]  Zhifu Sun,et al.  Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan‐cancer analysis , 2020, Cancer communications.

[14]  Zemin Zhang,et al.  GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis , 2019, Nucleic Acids Res..

[15]  Prashanth Rawla,et al.  Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors , 2019, World journal of oncology.

[16]  B. Sirohi,et al.  Indian council of medical research consensus document for the management of pancreatic cancer , 2019, Indian Journal of Medical and Paediatric Oncology.

[17]  D. Laheru,et al.  Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summary. , 2017, Journal of oncology practice.

[18]  Stephen L. Abrams,et al.  Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells. , 2015, Advances in biological regulation.

[19]  Dong Shik Lee,et al.  EGFR expression in pancreatic intraepithelial neoplasia and ductal adenocarcinoma. , 2015, International journal of clinical and experimental pathology.

[20]  Shufeng Zhou,et al.  Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells , 2015, Drug design, development and therapy.

[21]  A. Avan,et al.  EGFR as a potential target for the treatment of pancreatic cancer: dilemma and controversies. , 2014, Current drug targets.

[22]  W. Park,et al.  EGF-induced expression of Fused Toes Homolog (FTS) facilitates epithelial-mesenchymal transition and promotes cell migration in ME180 cervical cancer cells. , 2014, Cancer letters.

[23]  Zuyao Yang,et al.  Gemcitabine Plus Erlotinib for Advanced Pancreatic Cancer: A Systematic Review with Meta-Analysis , 2013, PloS one.

[24]  A. Verma,et al.  Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF‐κB signaling pathways , 2012, International journal of cancer.

[25]  Xiaogang Li,et al.  Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3. , 2012, Molecular medicine reports.

[26]  Stephen C Peiper,et al.  Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma , 2012, Cancer.

[27]  E. Giannoni,et al.  Anoikis: an emerging hallmark in health and diseases , 2012, The Journal of pathology.

[28]  J. Kim,et al.  Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells , 2010, BMC Cancer.

[29]  Arthur J. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[30]  M. Binker,et al.  EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2. , 2009, Biochemical and biophysical research communications.

[31]  Helmut Friess,et al.  Gefitinib ('Iressa', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. , 2004, International journal of oncology.

[32]  W. Goddard,et al.  UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations , 1992 .

[33]  M. Reni,et al.  Chemotherapy in elderly patients with pancreatic cancer: Efficacy, feasibility and future perspectives. , 2019, Cancer treatment reviews.

[34]  M. Hidalgo,et al.  More than a Gel & Hyaluronic Acid, a Central Component in the Microenvironment of Pancreatic Cancer , 2018 .

[35]  Arthur J Olson,et al.  Small-molecule library screening by docking with PyRx. , 2015, Methods in molecular biology.