Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia.

CONTEXT Traditionally, pneumonia developing in patients outside the hospital is categorized as community acquired, even if these patients have been receiving health care in an outpatient facility. Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired. OBJECTIVE To characterize the microbiology and outcomes among patients with culture-positive community-acquired pneumonia (CAP), health-care-associated pneumonia (HCAP), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP). DESIGN AND SETTING A retrospective cohort study based on a large US inpatient database. PATIENTS A total of 4,543 patients with culture-positive pneumonia admitted into 59 US hospitals between January 1, 2002, and December 31, 2003, and recorded in a large, multi-institutional database of US acute-care hospitals (Cardinal Health-Atlas Research Database; Cardinal Health Clinical Knowledge Services; Marlborough, MA). MAIN MEASURES Culture data (respiratory and blood), in-hospital mortality, length of hospital stay (LOS), and billed hospital charges. RESULTS Approximately one half of hospitalized patients with pneumonia had CAP, and > 20% had HCAP. Staphylococcus aureus was a major pathogen in all pneumonia types, with its occurrence markedly higher in the non-CAP groups than in the CAP group. Mortality rates associated with HCAP (19.8%) and HAP (18.8%) were comparable (p > 0.05), and both were significantly higher than that for CAP (10%, all p < 0.0001) and lower than that for VAP (29.3%, all p < 0.0001). Mean LOS varied significantly with pneumonia category (in order of ascending values: CAP, HCAP, HAP, and VAP; all p < 0.0001). Similarly, mean hospital charge varied significantly with pneumonia category (in order of ascending value: CAP, HCAP, HAP, and VAP; all p < 0.0001). CONCLUSIONS The present analysis justified HCAP as a new category of pneumonia. S aureus was a major pathogen of all pneumonias with higher rates in non-CAP pneumonias. Compared with CAP, non-CAP was associated with more severe disease, higher mortality rate, greater LOS, and increased cost.

[1]  D. McQuillen,et al.  Healthcare-associated pneumonia in adults: management principles to improve outcomes. , 2004, Infectious disease clinics of North America.

[2]  M. Niederman Review of treatment guidelines for community-acquired pneumonia. , 2004, The American journal of medicine.

[3]  E. Tacconelli,et al.  Methicillin-resistant Staphylococcus aureus bacteraemia diagnosed at hospital admission: distinguishing between community-acquired versus healthcare-associated strains. , 2004, The Journal of antimicrobial chemotherapy.

[4]  M. Woodhead,et al.  Guidelines for community-acquired pneumonia in the ICU , 2004, Current opinion in critical care.

[5]  R. Wunderink,et al.  Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin , 2004, Intensive Care Medicine.

[6]  Susan K. Johnson,et al.  Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. , 2003, JAMA.

[7]  John G. Bartlett,et al.  Update of Practice Guidelines for the Management of Community-Acquired Pneumonia in Immunocompetent Adults , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  Allan D. Stowers,et al.  Community-acquired Pneumonia: Compliance with Centers for Medicare and Medicaid Services, National Guidelines, and Factors Associated with Outcome , 2003, Southern medical journal.

[9]  P. Tambyah,et al.  Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection in Singapore Is Usually “Healthcare Associated” , 2003, Infection Control &#x0026; Hospital Epidemiology.

[10]  Jordi Rello,et al.  Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. , 2002, Chest.

[11]  Daniel J Sexton,et al.  Health CareAssociated Bloodstream Infections in Adults: A Reason To Change the Accepted Definition of Community-Acquired Infections , 2002, Annals of Internal Medicine.

[12]  W. Jarvis,et al.  Would Active Surveillance Cultures Help Control Healthcare-Related Methicillin-Resistant Staphylococcus aureus Infections? , 2002, Infection Control &#x0026; Hospital Epidemiology.

[13]  W. Lim,et al.  BTS Guidelines for the Management of Community Acquired Pneumonia in Adults , 2001, Thorax.

[14]  J. Hadler,et al.  Population-based incidence and characteristics of community-onset Staphylococcus aureus infections with bacteremia in 4 metropolitan Connecticut areas, 1998. , 2001, The Journal of infectious diseases.

[15]  Jean-Yves Fagon,et al.  Ventilator-associated pneumonia. , 2002, American journal of respiratory and critical care medicine.

[16]  T. File The epidemiology of respiratory tract infections. , 2000, Seminars in respiratory infections.

[17]  Michael J Fine,et al.  Practice Guidelines for the Management of Community-Acquired Pneumonia in Adults , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[18]  L. Mandell,et al.  Canadian guidelines for the initial management of community-acquired pneumonia: an evidence-based update by the Canadian Infectious Diseases Society and the Canadian Thoracic Society. The Canadian Community-Acquired Pneumonia Working Group. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  B. Cookson Methicillin-Resistant Staphylococcus aureus in the Community: New Battlefronts, or Are the Battles Lost? , 2000, Infection Control &#x0026; Hospital Epidemiology.

[20]  J. Bartlett,et al.  GUIDELINES FROM THE INFECTIOUS DISEASES SOCIETY OF AMERICA Community-Acquired Pneumonia in Adults: Guidelines for Management , 1998 .

[21]  J. Rello,et al.  The value of routine microbial investigation in ventilator-associated pneumonia. , 1997, American journal of respiratory and critical care medicine.

[22]  J. Guest,et al.  Community-acquired pneumonia: the annual cost to the National Health Service in the UK. , 1997, The European respiratory journal.

[23]  M. Fine,et al.  A prediction rule to identify low-risk patients with community-acquired pneumonia. , 1997, The New England journal of medicine.

[24]  M. Fine,et al.  Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. , 1996, JAMA.

[25]  Sankey V. Williams,et al.  Evaluation of the complication rate as a measure of quality of care in coronary artery bypass graft surgery. , 1995, JAMA.

[26]  G. Coffman,et al.  Admission and Mid-Stay MedisGroups® Scores as Predictors of Hospitalization Charges , 1991, Medical care.

[27]  L I Iezzoni,et al.  A clinical assessment of MedisGroups. , 1988, JAMA.

[28]  Mark A. Moskowitz,et al.  A Clinical Assessment of Medis-Groups , 1988 .

[29]  J M Hughes,et al.  CDC definitions for nosocomial infections, 1988. , 1988, American journal of infection control.

[30]  J. Enders,et al.  Infectious Diseases Society of America. , 1969, Antimicrobial agents and chemotherapy.

[31]  J. Bartlett Timing of antibiotic administration and outcomes for medicare patients hospitalized with community-acquired pneumonia , 2004 .

[32]  T. Marrie Community-Acquired Pneumonia , 2002, Springer US.

[33]  M. Fine,et al.  Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. , 2001, American journal of respiratory and critical care medicine.

[34]  J. Bartlett,et al.  Community-acquired pneumonia in adults: guidelines for management. The Infectious Diseases Society of America. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[35]  Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies. A consensus statement, American Thoracic Society, November 1995. , 1996, American journal of respiratory and critical care medicine.

[36]  L. Mandell,et al.  Hospital-acquired pneumonia in adults: Diagnosis, assessment of severity, initial antimicrobial therapy, and preventative strategies: A consensus statement , 1996 .

[37]  CDC definitions for nosocomial infections, 1988. , 1989, The American review of respiratory disease.