The C/EBP family of transcription factors.

[1]  Nobuaki Yoshida,et al.  Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages , 1995, Cell.

[2]  S. McKnight,et al.  Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. , 1995, Genes & development.

[3]  V. Baichwal,et al.  Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. Leutz,et al.  Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression. , 1994, Genes & development.

[5]  S. Ness,et al.  C/EBP beta regulation of the tumor necrosis factor alpha gene. , 1994, The Journal of clinical investigation.

[6]  J. Diehl,et al.  Identification of a C/EBP-Rel complex in avian lymphoid cells , 1994, Molecular and cellular biology.

[7]  M. Lane,et al.  CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. Buck,et al.  LAP (NF-IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region. , 1994, The Journal of clinical investigation.

[9]  M. Baer,et al.  C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[10]  D. Chaplin,et al.  Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1 beta gene. , 1994, Journal of immunology.

[11]  B. Ray,et al.  Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation , 1994, Molecular and cellular biology.

[12]  B. Ray,et al.  Expression of the gene encoding α1-acid glycoprotein in rabbit liver under acute-phase conditions involves induction and activation of β and δ CCAAT-enhancer-binding proteins , 1994 .

[13]  A. Diehl,et al.  Regenerative changes in C/EBPα and C/EBPß expression modulate binding to the C/EBP site in the c‐fos promoter , 1994 .

[14]  M. Buck,et al.  LAP (NF‐IL‐6), a tissue‐specific transcriptional activator, is an inhibitor of hepatoma cell proliferation. , 1994, The EMBO journal.

[15]  M. Yano,et al.  A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor , 1994, Molecular and cellular biology.

[16]  D. R. Wilson,et al.  The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain. , 1994, The Journal of biological chemistry.

[17]  T. Curran,et al.  Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region , 1994, Molecular and cellular biology.

[18]  W. Liao,et al.  Differential acute-phase response of rat kininogen genes involves type I and type II interleukin-6 response elements. , 1993, The Journal of biological chemistry.

[19]  M. Zakin,et al.  A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells. , 1993, The Journal of biological chemistry.

[20]  A. Baldwin,et al.  Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B , 1993, Molecular and Cellular Biology.

[21]  S. Akira,et al.  Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Plumb,et al.  C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene , 1993, Molecular and cellular biology.

[23]  U. Schibler,et al.  CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[24]  C. Trautwein,et al.  Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain , 1993, Nature.

[25]  C. Hsieh,et al.  trans-activation of the alpha 1-acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor. , 1993, The Journal of biological chemistry.

[26]  A. Baldwin,et al.  Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction. , 1993, Molecular and cellular biology.

[27]  C. Vinson,et al.  Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design. , 1993, Genes & development.

[28]  D. Ron,et al.  C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Ringwald,et al.  Synergistic activation of the chicken mim‐1 gene by v‐myb and C/EBP transcription factors. , 1993, The EMBO journal.

[30]  T. Graf,et al.  Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. , 1993, Genes & development.

[31]  D. R. Wilson,et al.  Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  A. Leutz,et al.  The NF‐M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. , 1993, The EMBO journal.

[33]  S. Akira,et al.  Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[34]  S. Akira,et al.  A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction , 1993, Molecular and cellular biology.

[35]  B. Müller-Hill,et al.  Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF‐1 that are involved in specific DNA binding. , 1993, The EMBO journal.

[36]  V. Maréchal,et al.  The DNA-binding domain of two bZIP transcription factors, the Epstein-Barr virus switch gene product EB1 and Jun, is a bipartite nuclear targeting sequence , 1993, Journal of virology.

[37]  R. Cortese,et al.  The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms , 1993 .

[38]  K. Struhl,et al.  The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex , 1992, Cell.

[39]  K. Calame,et al.  The C/EBP family of transcriptional activators is functionally important for Ig VH promoter activity in vivo and in vitro. , 1992, Journal of immunology.

[40]  A. Ruddell,et al.  a1/EBP: a leucine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer , 1992, Journal of virology.

[41]  A. Spradling,et al.  slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C EBP , 1992, Cell.

[42]  N. Raikhel,et al.  Nuclear localization signal(s) required for nuclear targeting of the maize regulatory protein Opaque-2. , 1992, The Plant cell.

[43]  P. Rørth,et al.  A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. , 1992, Blood.

[44]  S. McKnight,et al.  Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding. , 1992, The Journal of biological chemistry.

[45]  Andrew J. Bannister,et al.  Conserved motifs in Fos and Jun define a new class of activation domain. , 1992, Genes & development.

[46]  P. Sharp,et al.  The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[47]  J. Haas,et al.  Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif. , 1992, Journal of immunology.

[48]  M. Guertin,et al.  Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the α1-fetoprotein gene. Further analysis of C/EBPβ and C/EBPγ , 1992 .

[49]  P. Vogt,et al.  Nuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Rosenfeld,et al.  Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ , 1992, Science.

[51]  S. Freytag,et al.  Reciprocal Regulation of Adipogenesis by Myc and C/EBPα , 1992, Science.

[52]  M. Lane,et al.  Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. , 1992, Genes & development.

[53]  M. Nishizawa,et al.  cDNA clones encoding leucine‐zipper proteins which interact with G‐CSF gene promoter element 1‐binding protein , 1992, FEBS letters.

[54]  D. Ron,et al.  CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. , 1992, Genes & development.

[55]  S. Akira,et al.  A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[56]  S. Akira,et al.  Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. , 1992, Blood.

[57]  U. Schibler,et al.  A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA , 1991, Cell.

[58]  P. S. Kim,et al.  X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. , 1991, Science.

[59]  J. Wijnholds,et al.  Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene. , 1991, Nucleic acids research.

[60]  R. Umek,et al.  Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. , 1991, Genes & development.

[61]  P. Johnson,et al.  A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. , 1991, Genes & development.

[62]  J E Darnell,et al.  The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[63]  C. Shih,et al.  An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP , 1991, Molecular and cellular biology.

[64]  R. Umek,et al.  CCAAT-enhancer binding protein: a component of a differentiation switch. , 1991, Science.

[65]  P S Kim,et al.  X-ray scattering indicates that the leucine zipper is a coiled coil. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[66]  D. Ron,et al.  A family of constitutive C/EBP‐like DNA binding proteins attenuate the IL‐1 alpha induced, NF kappa B mediated trans‐activation of the angiotensinogen gene acute‐phase response element. , 1990, The EMBO journal.

[67]  G. Fey,et al.  A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6 , 1990, Molecular and cellular biology.

[68]  H. Lei,et al.  Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family , 1990, Molecular and cellular biology.

[69]  J. Liu,et al.  The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP) , 1990, Molecular and cellular biology.

[70]  R. Cortese,et al.  IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C EBP , 1990, Cell.

[71]  U. Schibler,et al.  LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. , 1990, Genes & development.

[72]  W. DeGrado,et al.  Design of DNA-binding peptides based on the leucine zipper motif. , 1990, Science.

[73]  S. McKnight,et al.  Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP. , 1990, Science.

[74]  P. S. Kim,et al.  Sequence-specific DNA binding by a short peptide dimer. , 1990, Science.

[75]  K. Calame,et al.  Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. , 1990, Genes & development.

[76]  D. Crothers,et al.  Molecular characterization of the GCN4-DNA complex. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[77]  S. McKnight,et al.  Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene. , 1990, Genes & development.

[78]  S. Akira,et al.  Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene , 1990, Molecular and cellular biology.

[79]  S. Akira,et al.  A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family. , 1990, The EMBO journal.

[80]  P. Dervan,et al.  Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving. , 1990, Science.

[81]  P. S. Kim,et al.  Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. , 1990, Biochemistry.

[82]  G. Ciliberto,et al.  Constitutive and IL‐6‐induced nuclear factors that interact with the human C‐reactive protein promoter. , 1990, The EMBO journal.

[83]  S. McKnight,et al.  Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP. , 1989, Science.

[84]  S. McKnight,et al.  Scissors-grip model for DNA recognition by a family of leucine zipper proteins. , 1989, Science.

[85]  T. Kouzarides,et al.  Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding , 1989, Nature.

[86]  J. Gordon,et al.  Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. , 1989, Genes & development.

[87]  P. S. Kim,et al.  Evidence that the leucine zipper is a coiled coil. , 1989, Science.

[88]  S. McKnight,et al.  Isolation of a recombinant copy of the gene encoding C/EBP. , 1988, Genes & development.

[89]  S. McKnight,et al.  The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. , 1988, Science.

[90]  S. McKnight,et al.  Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. , 1987, Genes & development.

[91]  K. Struhl,et al.  Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast , 1986, Cell.

[92]  H. Hurst.  Transcription factors 1: bZIP proteins. , 1995, Protein profile.

[93]  S. McKnight,et al.  Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. , 1991, Trends in biochemical sciences.

[94]  K. Kaestner,et al.  Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein. , 1990, Proceedings of the National Academy of Sciences of the United States of America.