Graphene oxide-based magnetic fluorescent hybrids for drug delivery and cellular imaging.

A graphene oxide (GO)-based multifunctional hybrid has been developed for loading and delivery of anticancer drugs. The GO was functionalized by magnetic/fluorescent SiO2 microsphere via an amidation process. Doxorubicin (DOX) was chosen as a model drug to be loaded onto the GO via π-π stacking and hydrophobic interaction. The loading capacities of DOX to the GO-based magnetic fluorescent hybrids were investigated. The release profiles of DOX from the hybrids were depicted. The fluorescence images of the GO-based magnetic fluorescent hybrids indicated that the hybrids would be an effective drug carrier and a potential optical imaging tool. The application of the developed GO-based magnetic fluorescent hybrids for HepG2 cells demonstrated an excellent therapeutic effect of the DOX loaded hybrids to the target tumor.

[1]  Zhuang Liu,et al.  Nano-graphene oxide for cellular imaging and drug delivery , 2008, Nano research.

[2]  R. Ruoff,et al.  Graphene and Graphene Oxide: Synthesis, Properties, and Applications , 2010, Advanced materials.

[3]  M. Hummelgård,et al.  Real time monitoring of the drug release of rhodamine B on graphene oxide , 2011 .

[4]  Jing Li,et al.  Hemin-graphene hybrid nanosheets with intrinsic peroxidase-like activity for label-free colorimetric detection of single-nucleotide polymorphism. , 2011, ACS nano.

[5]  Zhijun Zhang,et al.  Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. , 2010, Small.

[6]  Yanli Chang,et al.  A Facile One‐step Method to Produce Graphene–CdS Quantum Dot Nanocomposites as Promising Optoelectronic Materials , 2010, Advanced materials.

[7]  H. Dai,et al.  Photothermally enhanced drug delivery by ultrasmall multifunctional FeCo/graphitic shell nanocrystals. , 2011, ACS nano.

[8]  Hongjie Dai,et al.  Supramolecular Chemistry on Water- Soluble Carbon Nanotubes for Drug Loading and Delivery , 2007 .

[9]  Yuan Ping,et al.  Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. , 2011, Small.

[10]  Zhuang Liu,et al.  PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. , 2008, Journal of the American Chemical Society.

[11]  Lin Li,et al.  Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study. , 2011, Chemical communications.

[12]  Andre K. Geim,et al.  The rise of graphene. , 2007, Nature materials.

[13]  H. Dai,et al.  Chemically Derived, Ultrasmooth Graphene Nanoribbon Semiconductors , 2008, Science.

[14]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[15]  Q. Ma,et al.  The Synthesis of Magnetic and Fluorescent Bi-functional Silica Composite Nanoparticles via Reverse Microemulsion Method , 2009, Journal of Fluorescence.

[16]  Fengmin Liu,et al.  Solid-state potentiometric H2S sensor combining NASICON with Pr6O11-doped SnO2 electrode , 2007 .

[17]  Hongbing Zhan,et al.  Lossless synthesis of graphene nanosheets decorated with tiny cadmium sulfide quantum dots with excellent nonlinear optical properties , 2010, Nanotechnology.

[18]  Z. Xiong,et al.  Pillaring chemically exfoliated graphene oxide with carbon nanotubes for photocatalytic degradation of dyes under visible light irradiation. , 2010, ACS nano.

[19]  Weihong Tan,et al.  A versatile graphene-based fluorescence "on/off" switch for multiplex detection of various targets. , 2011, Biosensors & bioelectronics.

[20]  Yuehe Lin,et al.  Graphene and graphene oxide: biofunctionalization and applications in biotechnology , 2011, Trends in Biotechnology.

[21]  Yang Xu,et al.  Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. , 2010, ACS nano.

[22]  Chengzhou Zhu,et al.  One-step, solvothermal synthesis of graphene-CdS and graphene-ZnS quantum dot nanocomposites and their interesting photovoltaic properties , 2010 .

[23]  Yan Li,et al.  Adsorption and removal of tetracycline antibiotics from aqueous solution by graphene oxide. , 2012, Journal of colloid and interface science.

[24]  Jun-Sung Kim,et al.  Cellular uptake of magnetic nanoparticle is mediated through energy-dependent endocytosis in A549 cells , 2006, Journal of veterinary science.

[25]  Yongsheng Chen,et al.  High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide , 2008 .

[26]  X. Su,et al.  Highly sensitive and selective detection of biothiols using graphene oxide-based "molecular beacon"-like fluorescent probe. , 2012, Analytica chimica acta.