Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.
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S. Brady | J. Vacca | S. Gardell | J. Lin | E. A. Lyle | W C Lumma | J. Lynch | W. C. Lumma | B. J. Lucas | I. Chen | A. Naylor-Olsen | J P Vacca | J H Lin | H G Ramjit | G M Smith | J J Lynch | I W Chen | J. Cook | K J Stauffer | S D Lewis | S J Gardell | B J Lucas | E A Lyle | S D Appleby | A M Naylor-Olsen | S F Brady | J J Cook | M T Stranieri | M A Holahan | M. Holahan | K Vastag | K. Vastag | H. Ramjit | K. J. Stauffer | S. Lewis | S. Appleby | M. Stranieri | G. M. Smith | E. Lyle | K. Stauffer