Emerging Two-Dimensional Nanomaterials for Cancer Therapy.

Two-dimensional (2D) nanomaterials have drawn tremendous attentions due to their unique physicochemical properties and promising applications in the fields of electronics, energy storage, and catalysis. Recently, the biomedicine community has gradually started to recognize the great potential of these nanostructured materials for biomedical applications - in particular those related to cancer therapy. In this review, we provide a brief overview on a few representative 2D nanomaterials, discuss their preparation strategies and physicochemical properties, and highlight their applications in cancer nanomedicine. We expect that this review will shed some light on the new opportunities associated with 2D nanomaterials for biomedical research.

[1]  P. Kantoff,et al.  Cancer nanomedicine: progress, challenges and opportunities , 2016, Nature Reviews Cancer.

[2]  M. Devika,et al.  Review on Tin (II) Sulfide (SnS) Material: Synthesis, Properties, and Applications , 2015 .

[3]  Zhuang Liu,et al.  2D MoS2 Nanostructures for Biomedical Applications , 2018, Advanced healthcare materials.

[4]  V. Presser,et al.  Two‐Dimensional Nanocrystals Produced by Exfoliation of Ti3AlC2 , 2011, Advanced materials.

[5]  O. N. Oliveira,et al.  Nanomaterials for diagnosis: challenges and applications in smart devices based on molecular recognition. , 2014, ACS applied materials & interfaces.

[6]  J. Soler,et al.  Efficient implementation of a van der Waals density functional: application to double-wall carbon nanotubes. , 2008, Physical review letters.

[7]  Ya-Fan Zhao,et al.  Planar hexagonal B36 as a potential basis for extended single-atom layer boron sheets , 2014, Nature Communications.

[8]  F. Xia,et al.  Ultrafast graphene photodetector , 2009, CLEO/QELS: 2010 Laser Science to Photonic Applications.

[9]  O. Farokhzad,et al.  Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo , 2017, Theranostics.

[10]  A. Szuplewska,et al.  In vitro studies on cytotoxicity of delaminated Ti3C2 MXene. , 2017, Journal of hazardous materials.

[11]  Qing Hua Wang,et al.  Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. , 2012, Nature nanotechnology.

[12]  Jundong Shao,et al.  From Black Phosphorus to Phosphorene: Basic Solvent Exfoliation, Evolution of Raman Scattering, and Applications to Ultrafast Photonics , 2015 .

[13]  Alessandro Molle,et al.  Buckled two-dimensional Xene sheets. , 2017, Nature materials.

[14]  Alicia Fernandez-Fernandez,et al.  Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms , 2011, Applied biochemistry and biotechnology.

[15]  Lianzhou Wang,et al.  Break‐up of Two‐Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer , 2014, Advanced materials.

[16]  Liang Cheng,et al.  Organic-Base-Driven Intercalation and Delamination for the Production of Functionalized Titanium Carbide Nanosheets with Superior Photothermal Therapeutic Performance. , 2016, Angewandte Chemie.

[17]  J. Gómez‐Herrero,et al.  Recent Progress on Antimonene: A New Bidimensional Material , 2018, Advanced materials.

[18]  Zhuang Liu,et al.  PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. , 2008, Journal of the American Chemical Society.

[19]  Warren C W Chan,et al.  Mediating tumor targeting efficiency of nanoparticles through design. , 2009, Nano letters.

[20]  Hui-Ming Cheng,et al.  Chemical Vapor Deposition Growth and Applications of Two-Dimensional Materials and Their Heterostructures. , 2018, Chemical reviews.

[21]  Catherine J. Murphy,et al.  Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? , 2010, Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology.

[22]  S. Lebègue,et al.  Electronic structure of two-dimensional crystals from ab-initio theory , 2009, 0901.0440.

[23]  Yoshiyuki Kawazoe,et al.  Novel Electronic and Magnetic Properties of Two‐Dimensional Transition Metal Carbides and Nitrides , 2013 .

[24]  H. Summers,et al.  Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines , 2018, Advanced materials.

[25]  Mark C Hersam,et al.  Solution-Based Processing of Monodisperse Two-Dimensional Nanomaterials. , 2017, Accounts of chemical research.

[26]  G. Eda,et al.  Conducting MoS₂ nanosheets as catalysts for hydrogen evolution reaction. , 2013, Nano letters.

[27]  M. Uesaka,et al.  Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. , 2011, Nature nanotechnology.

[28]  Andrew Emili,et al.  Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. , 2012, Journal of the American Chemical Society.

[29]  Y. Li,et al.  Two‐Dimensional Boron Crystals: Structural Stability, Tunable Properties, Fabrications and Applications , 2017 .

[30]  Andre K. Geim,et al.  The rise of graphene. , 2007, Nature materials.

[31]  C. Fernandes,et al.  Tumor Microenvironment Targeted Nanotherapy , 2018, Front. Pharmacol..

[32]  Qiyuan He,et al.  Recent Advances in Ultrathin Two-Dimensional Nanomaterials. , 2017, Chemical reviews.

[33]  F. Wang,et al.  Two dimensional hexagonal boron nitride (2D-hBN): synthesis, properties and applications , 2017 .

[34]  Laura M Ensign,et al.  PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. , 2016, Advanced drug delivery reviews.

[35]  H. Su,et al.  Phosphorene: from theory to applications , 2016 .

[36]  Yu Chen,et al.  Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead , 2018, Advanced science.

[37]  O. Farokhzad,et al.  A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins , 2014, Nano letters.

[38]  Bing Wang,et al.  Metabolism of nanomaterials in vivo: blood circulation and organ clearance. , 2013, Accounts of chemical research.

[39]  Martin Pumera,et al.  Transition metal dichalcogenides (MoS2, MoSe2, WS2 and WSe2) exfoliation technique has strong influence upon their capacitance , 2015 .

[40]  X. Ji,et al.  Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging‐Guided Combinatorial Chemo‐Photothermal Therapy , 2017, Advanced functional materials.

[41]  Han Zhang,et al.  A Novel Top‐Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging‐Guided Cancer Therapy , 2018, Advanced materials.

[42]  Mark C. Hersam,et al.  Synthesis and chemistry of elemental 2D materials , 2017 .

[43]  Liangbing Hu,et al.  Approaching the limits of transparency and conductivity in graphitic materials through lithium intercalation. , 2014, Nature communications.

[44]  J. Rao Shedding light on tumors using nanoparticles. , 2008, ACS nano.

[45]  Hua Zhang,et al.  2D nanomaterials: graphene and transition metal dichalcogenides. , 2018, Chemical Society reviews.

[46]  Chuanqi Peng,et al.  Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density. , 2016, Angewandte Chemie.

[47]  S. Haigh,et al.  Tin(II) Sulfide (SnS) Nanosheets by Liquid-Phase Exfoliation of Herzenbergite: IV-VI Main Group Two-Dimensional Atomic Crystals. , 2015, Journal of the American Chemical Society.

[48]  William C Zamboni,et al.  Nanoparticles and the mononuclear phagocyte system: pharmacokinetics and applications for inflammatory diseases. , 2014, Current rheumatology reviews.

[49]  D. Gu,et al.  Two-Dimensional Nanomaterials for Gas Sensing Applications: The Role of Theoretical Calculations , 2018, Nanomaterials.

[50]  Wei Tao,et al.  Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects , 2016, Theranostics.

[51]  Jing Lin,et al.  Two-dimensional transition metal carbides and nitrides (MXenes) for biomedical applications. , 2018, Chemical Society reviews.

[52]  Yury Gogotsi,et al.  2D metal carbides and nitrides (MXenes) for energy storage , 2017 .

[53]  Yury Gogotsi,et al.  25th Anniversary Article: MXenes: A New Family of Two‐Dimensional Materials , 2014, Advanced materials.

[54]  D. Fan,et al.  Black phosphorus analogue tin sulfide nanosheets: synthesis and application as near-infrared photothermal agents and drug delivery platforms for cancer therapy. , 2018, Journal of materials chemistry. B.

[55]  Yao-Xin Lin,et al.  Polydopamine‐Modified Black Phosphorous Nanocapsule with Enhanced Stability and Photothermal Performance for Tumor Multimodal Treatments , 2018, Advanced science.

[56]  H. Zeng,et al.  Semiconducting Group 15 Monolayers: A Broad Range of Band Gaps and High Carrier Mobilities. , 2016, Angewandte Chemie.

[57]  H. Hillebrecht,et al.  Boron: elementary challenge for experimenters and theoreticians. , 2009, Angewandte Chemie.

[58]  Dan Peer,et al.  Progress and challenges towards targeted delivery of cancer therapeutics , 2018, Nature Communications.

[59]  L. Nazar,et al.  Interwoven MXene Nanosheet/Carbon‐Nanotube Composites as Li–S Cathode Hosts , 2017, Advanced materials.

[60]  O. Farokhzad,et al.  Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy. , 2018, ACS nano.

[61]  J. Zou,et al.  Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy. , 2017, ACS applied materials & interfaces.

[62]  Xianfan Xu,et al.  Phosphorene: an unexplored 2D semiconductor with a high hole mobility. , 2014, ACS nano.

[63]  O. Farokhzad,et al.  Two‐Dimensional Antimonene‐Based Photonic Nanomedicine for Cancer Theranostics , 2018, Advanced materials.

[64]  Peng Wang,et al.  MXene Ti3C2: An Effective 2D Light-to-Heat Conversion Material. , 2017, ACS nano.

[65]  Yong-Wei Zhang,et al.  Nanoscale Transition Metal Dichalcogenides: Structures, Properties, and Applications , 2014 .

[66]  Susan Wijnhoven,et al.  Risk assessment frameworks for nanomaterials: Scope, link to regulations, applicability, and outline for future directions in view of needed increase in efficiency , 2018 .

[67]  Suresh C Pillai,et al.  2D nanostructures for water purification: graphene and beyond. , 2016, Nanoscale.

[68]  Thomas Heine,et al.  Influence of quantum confinement on the electronic structure of the transition metal sulfide T S 2 , 2011, 1104.3670.

[69]  Istvan Toth,et al.  Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. , 2011, Nature nanotechnology.

[70]  José M. Morachis,et al.  Physical and Chemical Strategies for Therapeutic Delivery by Using Polymeric Nanoparticles , 2012, Pharmacological Reviews.

[71]  I. Wistuba,et al.  Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment , 2015, Proceedings of the National Academy of Sciences.

[72]  Xiaoyuan Chen,et al.  Suppressing Nanoparticle-Mononuclear Phagocyte System Interactions of Two-Dimensional Gold Nanorings for Improved Tumor Accumulation and Photothermal Ablation of Tumors. , 2017, ACS nano.

[73]  Han Lin,et al.  Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation. , 2017, ACS nano.

[74]  David G. Evans,et al.  Assembly Chemistry of Anion-intercalated Layered Materials , 2011 .

[75]  Han Lin,et al.  A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows. , 2017, Journal of the American Chemical Society.

[76]  Vinayak Sant,et al.  Graphene-based nanomaterials for drug delivery and tissue engineering. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[77]  Xianfan Xu,et al.  Phosphorene: an unexplored 2D semiconductor with a high hole mobility. , 2014, ACS nano.

[78]  Hua Zhang,et al.  Wet-chemical synthesis and applications of non-layer structured two-dimensional nanomaterials , 2015, Nature Communications.

[79]  Thalappil Pradeep,et al.  Anisotropic nanomaterials: structure, growth, assembly, and functions , 2011, Nano reviews.

[80]  C. Rao,et al.  Transition metal sulfides , 1976 .

[81]  Han Zhang,et al.  Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics , 2017, Advanced materials.

[82]  O. Farokhzad,et al.  Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy. , 2017, Angewandte Chemie.

[83]  A. Sikorski,et al.  Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challenges , 2015, International journal of nanomedicine.

[84]  Y. Jiao,et al.  Emerging Two-Dimensional Nanomaterials for Electrocatalysis. , 2018, Chemical reviews.

[85]  Y. Gogotsi,et al.  Synthesis of two-dimensional materials by selective extraction. , 2015, Accounts of chemical research.

[86]  F. Pan,et al.  Few-Layer Tin Sulfide: A New Black-Phosphorus-Analogue 2D Material with a Sizeable Band Gap, Odd–Even Quantum Confinement Effect, and High Carrier Mobility , 2016 .

[87]  R. Banerjee,et al.  Targeted Drug Delivery in Covalent Organic Nanosheets (CONs) via Sequential Postsynthetic Modification. , 2017, Journal of the American Chemical Society.

[88]  Lele Peng,et al.  Two dimensional nanomaterials for flexible supercapacitors. , 2014, Chemical Society reviews.

[89]  A. Ciesielski,et al.  Graphene via sonication assisted liquid-phase exfoliation. , 2014, Chemical Society reviews.

[90]  Z. Qian,et al.  The in vitro and in vivo toxicity of gold nanoparticles , 2017 .

[91]  Marco P Monopoli,et al.  Biomolecular coronas provide the biological identity of nanosized materials. , 2012, Nature nanotechnology.

[92]  H. Dai,et al.  PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. , 2009, Journal of the American Chemical Society.

[93]  H. Hillebrecht,et al.  Bor – elementare Herausforderung für Experimentatoren und Theoretiker , 2009 .

[94]  U. Nielsen,et al.  Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. , 2006, Cancer research.

[95]  Steven D. Lacey,et al.  Tuning two-dimensional nanomaterials by intercalation: materials, properties and applications. , 2016, Chemical Society reviews.

[96]  R. C. Campos,et al.  Direct determination of tin in whole blood and urine by GF AAS. , 2013, Clinical biochemistry.

[97]  Alessandro Molle (Invited) Xenes: A New Emerging Two-Dimensional Materials Platform for Nanoelectronics , 2016 .

[98]  A. Amiri,et al.  Promoting Role of MXene Nanosheets in Biomedical Sciences: Therapeutic and Biosensing Innovations , 2018, Advanced healthcare materials.

[99]  P. Vogt Silicene, germanene and other group IV 2D materials , 2018, Beilstein journal of nanotechnology.

[100]  X. Duan,et al.  Van der Waals heterostructures and devices , 2016 .

[101]  A. Gaharwar,et al.  Two‐Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects , 2015, Advanced materials.

[102]  A. N. Gandi,et al.  Thermal conductivity of bulk and monolayer MoS2 , 2016 .