mHERC6 is the essential ISG15 E3 ligase in the murine system.

[1]  Ivan Dikic,et al.  The spatial and temporal organization of ubiquitin networks , 2011, Nature Reviews Molecular Cell Biology.

[2]  G. Sauter,et al.  Control of bone formation by the serpentine receptor Frizzled-9 , 2011, The Journal of cell biology.

[3]  Zhijian J. Chen,et al.  Emerging Role of ISG15 in Antiviral Immunity , 2010, Cell.

[4]  J. Huibregtse,et al.  The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15 , 2010, Molecular Cell.

[5]  A. García-Sastre,et al.  Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein , 2010, Journal of Virology.

[6]  Rei-Lin Kuo,et al.  ISG15 conjugation system targets the viral NS1 protein in influenza A virus–infected cells , 2010, Proceedings of the National Academy of Sciences.

[7]  R. Krug,et al.  Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells , 2009, Journal of Virology.

[8]  M. Hochstrasser,et al.  Origin and function of ubiquitin-like proteins , 2009, Nature.

[9]  Bryan R. G. Williams,et al.  Interferon-inducible antiviral effectors , 2008, Nature Reviews Immunology.

[10]  Robert Ménard,et al.  Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease , 2007, Archives of Biochemistry and Biophysics.

[11]  Dong-er Zhang,et al.  Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. , 2007, Biochemical and biophysical research communications.

[12]  K. Knobeloch,et al.  IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses , 2007, Proceedings of the National Academy of Sciences.

[13]  T. Junt,et al.  Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. , 2006, Blood.

[14]  N. Sze,et al.  HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[15]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.

[16]  Dong-er Zhang,et al.  The Interferon-inducible Ubiquitin-protein Isopeptide Ligase (E3) EFP Also Functions as an ISG15 E3 Ligase* , 2006, Journal of Biological Chemistry.

[17]  R. Krug,et al.  Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells* , 2006, Journal of Biological Chemistry.

[18]  E. Borden,et al.  Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. , 2005, Biochemical and biophysical research communications.

[19]  K. Knobeloch,et al.  ISG15, an Interferon-Stimulated Ubiquitin-Like Protein, Is Not Essential for STAT1 Signaling and Responses against Vesicular Stomatitis and Lymphocytic Choriomeningitis Virus , 2005, Molecular and Cellular Biology.

[20]  Steven Gygi,et al.  Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  B. Beutler,et al.  Enhanced Antibacterial Potential in UBP43-Deficient Mice against Salmonella typhimurium Infection by Up-Regulating Type I IFN Signaling1 , 2005, The Journal of Immunology.

[22]  J. L. Rosa,et al.  The HERC proteins: functional and evolutionary insights , 2005, Cellular and Molecular Life Sciences CMLS.

[23]  B. Binder,et al.  The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. , 2005, Genomics.

[24]  H. Virgin,et al.  Interferon-Inducible Ubiquitin E2, Ubc8, Is a Conjugating Enzyme for Protein ISGylation , 2004, Molecular and Cellular Biology.

[25]  R. Krug,et al.  The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein , 2004 .

[26]  R. Krug,et al.  Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)‐induced ubiquitin‐like ISG15 protein , 2001, The EMBO journal.

[27]  P. Howley,et al.  Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity* , 1997, The Journal of Biological Chemistry.

[28]  M. Scheffner,et al.  A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[29]  A. Haas,et al.  Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin. , 1987, The Journal of biological chemistry.

[30]  P. Lengyel,et al.  Accumulation of an mRNA and protein in interferon-treated Ehrlich ascites tumour cells , 1979, Nature.

[31]  R. Krug,et al.  Herc 5 , an Interferon-induced HECT E 3 Enzyme , Is Required for Conjugation of ISG 15 in Human Cells * , 2006 .

[32]  R. Krug,et al.  The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. , 2004, Proceedings of the National Academy of Sciences of the United States of America.