Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology

Chapter 1. Introduction: Metabolic Hydrolysis and Prodrug Design. Chapter 2. Classification, Localization, and Some Physiological Roles of Hydrolytic Enzymes. Chapter 3. Catalytic Mechanisms of Hydrolytic Enzymes. Chapter 4. The Hydrolysis of Amides. Chapter 5. The Hydrolysis of Lactams. Chapter 6. The Hydrolysis of Peptides. Chapter 7. The Hydrolysis of Carboxylic Acid Esters. Chapter 8. The Hydrolysis of Carboxylic Acid Ester Prodrugs. Chapter 9. The Cleavage of Esters of Inorganic Acids. Chapter 10. The Hydration of Epoxides. Chapter 11. Miscellaneous Reactions of Hydration and Dehydration. Chapter 12. Conclusion: The Biochemistry of Water. Index.