New optical probe approach using mixing effect in planar photodiode for biomedical applications

The laser diode self-mixing technique is a well-known and powerful interferometric technique that has been used in biomedical applications, namely for the extraction of cardiovascular parameters. However, to construct an optical probe using the self-mixing principle which is able to acquire signals in the human carotid artery, some problems are expected. The laser diode has a small aperture area, which means that, for physiological sensing purposes, it can be considered as a point-like detector. This feature imparts difficulties to quality recording of physiological signals since the number of photons collected and mixed in the cavity of the photodiode is very small. In order to overcome this problem, a new mixing geometry based on an external large area planar photodiode (PD) is used in the probe, enabling a much larger number of photons to be collected, hence improving the quality of the signal. In this work, the possibility to obtain the mixing effect outside the laser cavity using an external photodetector, such as a planar photodiode, is demonstrated. Two test benches were designed, both with of two reflectors. The first one, which reflects the light beam with the same frequency of the original one is fixed, and the second one, is movable, reflecting the Doppler shifted light to the photodetector. The first test bench has a fixed mirror in front of the movable mirror, creating an umbra and penumbra shadow above the movable mirror. To avoid this problem, another test bench was constructed using a wedged beam splitter (WSB) instead of a fixed mirror. This new assembly ensures the separation of a single input beam into multiple copies that undergo successive reflections and refractions. Some light waves are reflected by the planar surface of WSB, while other light beams are transmitted through the WSB, reaching the movable mirror. Also in this case, the movable mirror reflects the light with a Doppler frequency shift, and the PD receives both beams. The two test benches were designed to demonstrate that it is possible to obtain mixing effect outside the laser cavity, using a planar photodiode. The Doppler spectrograms from the signals acquired in the test benches show that the signal frequency changes along time which correspond to the modulus of the derivative of the mirror movement, as expected in the self-mixing signals. Nevertheless, the test bench A showed better results than the test bench B. This fact probably results from the attenuation that the original beam suffers in each reflection and refraction in the WBS. Tests developed in the test benches opened the possibility to construct a probe that uses a planar photodiode with a large area to collect medical signals, and improve the quality of the acquisition with a better SNR.

[1]  U. Morbiducci,et al.  Non-contact cardiac monitoring from carotid artery using optical vibrocardiography. , 2008, Medical engineering & physics.

[2]  Kalju Meigas,et al.  Pulse profile registration using self-mixing in a diode laser , 1998, Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).

[3]  Guido Giuliani,et al.  Laser diode self-mixing technique for sensing applications , 2002 .

[4]  Patrick Segers,et al.  Laser Doppler vibrometry for in vivo assessment of arterial stiffness , 2011, 2011 IEEE International Symposium on Medical Measurements and Applications.

[5]  Jukka Hast,et al.  Arterial pulse shape measurement using self-mixing effect in a diode laser , 2002 .

[6]  João Cardoso,et al.  Optical Methods for Local Pulse Wave Velocity Assessment , 2011, BIOSIGNALS.

[7]  Kalju Meigas,et al.  Continuous blood pressure monitoring using pulse wave delay , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[8]  H. Sorvoja Noninvasive blood pressure pulse detection and blood pressure determination , 2006 .

[9]  M. Grigioni,et al.  Optical Vibrocardiography: A Novel Tool for the Optical Monitoring of Cardiac Activity , 2006, Annals of Biomedical Engineering.

[10]  João Cardoso,et al.  Empirical mode decomposition for self-mixing Doppler signals of hemodynamic optical probes. , 2013, Physiological measurement.

[11]  M.D. Fox,et al.  No touch pulse measurement by optical interferometry , 1994, IEEE Transactions on Biomedical Engineering.

[12]  Risto Myllylä,et al.  Fiber-optic biosensor based on self-mixing interferometry , 2008, International Conference on Advanced Optical Materials and Devices.

[13]  F. Bony,et al.  Photodiode-free Doppler velocimeter based on self-mixing effect in commercial VCSELs , 2008, 2008 IEEE Sensors.

[14]  Jukka Hast,et al.  SELF-MIXING INTERFEROMETRY AND ITS APPLICATIONS IN NONINVASIVE PULSE DETECTION , 2003 .

[15]  Tiancai Zhang,et al.  Phase noise of diode laser in self-mixing interference. , 2005, Optics express.