Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

[1]  Da-Qiang Li,et al.  Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer—Opportunities, Challenges, and Limitations , 2012, Clinical Cancer Research.

[2]  W. Schmiegel,et al.  The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway. , 2012, Carcinogenesis.

[3]  Baiqu Huang,et al.  A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells , 2012, Oncogene.

[4]  B. Jiang,et al.  PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation , 2012, Tumor Biology.

[5]  T. Deroo,et al.  A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition , 2011, PloS one.

[6]  Judy H. Cho,et al.  Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. , 2011, Gastroenterology.

[7]  Judy H. Cho,et al.  Recent insights into the genetics of inflammatory bowel disease. , 2011, Gastroenterology.

[8]  C. Bernstein,et al.  5-Aminosalicylate Is Not Chemoprophylactic for Colorectal Cancer in IBD: A Population Based Study , 2011, The American Journal of Gastroenterology.

[9]  G. Baldwin,et al.  P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways. , 2010, Biochimica et biophysica acta.

[10]  Christopher R Weber,et al.  Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. , 2010, Gastroenterology.

[11]  E. Kandel,et al.  PAK1 as a therapeutic target , 2010, Expert opinion on therapeutic targets.

[12]  Linheng Li,et al.  Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. , 2010, Gastroenterology.

[13]  R. Zini,et al.  Mesalazine inhibits the β‐catenin signalling pathway acting through the upregulation of μ‐protocadherin gene in colo‐rectal cancer cells , 2010, Alimentary pharmacology & therapeutics.

[14]  A. Lyakhovich,et al.  Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine , 2009, Alimentary pharmacology & therapeutics.

[15]  Sharmistha Sarkar,et al.  A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss , 2009, Cell.

[16]  G. Baldwin,et al.  PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins. , 2008, Biochimica et biophysica acta.

[17]  S. Deacon,et al.  An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. , 2008, Chemistry & biology.

[18]  U. Knaus,et al.  PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac , 2008, Journal of Cell Science.

[19]  A. Rizzo,et al.  Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid. , 2008, Biochemical pharmacology.

[20]  D. Richel,et al.  Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity. , 2006, Carcinogenesis.

[21]  Gerd Schmitz,et al.  Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease , 2006, Journal of Molecular Medicine.

[22]  B. Gumbiner,et al.  Regulation of cadherin-mediated adhesion in morphogenesis , 2005, Nature Reviews Molecular Cell Biology.

[23]  J. Terdiman,et al.  Effect of 5-Aminosalicylate Use on Colorectal Cancer and Dysplasia Risk: A Systematic Review and Metaanalysis of Observational Studies , 2005, The American Journal of Gastroenterology.

[24]  J. Auwerx,et al.  Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ , 2005, The Journal of experimental medicine.

[25]  J. Hauser,et al.  Autocrine Transforming Growth Factor α Regulates Cell Adhesion by Multiple Signaling via Specific Phosphorylation Sites of p70S6 Kinase in Colon Cancer Cells* , 2004, Journal of Biological Chemistry.

[26]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[27]  J. Deddens,et al.  Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis , 2004, Clinical Cancer Research.

[28]  R. Rao,et al.  Expression of Kinase-inactive c-Src Delays Oxidative Stress-induced Disassembly and Accelerates Calcium-mediated Reassembly of Tight Junctions in the Caco-2 Cell Monolayer* , 2003, The Journal of Biological Chemistry.

[29]  W. Sandborn,et al.  Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity* , 1999, The Journal of Biological Chemistry.

[30]  A. Weaver,et al.  Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[31]  W. Doe,et al.  5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells , 1999, Gut.

[32]  W. Bodmer,et al.  Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells , 1998 .

[33]  K. Kinzler,et al.  Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.

[34]  C. Lo,et al.  Impedance analysis of MDCK cells measured by electric cell-substrate impedance sensing. , 1995, Biophysical journal.

[35]  E. Stange,et al.  Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. , 1991, Scandinavian journal of gastroenterology.

[36]  N. Svartz.  Sulfasalazine: II. Some notes on the discovery and development of salazopyrin. , 1988, The American journal of gastroenterology.

[37]  T. Kunkel,et al.  5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. , 2007, Gastroenterology.

[38]  Jian Ni,et al.  Applications of the MTT assay to functional studies of mouse intestinal intraepithelial lymphocytes , 1996, Journal of clinical laboratory analysis.