Optoacoustic imaging using interferometric measurement of surface displacement

We describe an optoacoustic imaging technique based on time-resolved measurements of laser-induced thermoelastic expansion. Tomographic images of tissue phantoms are formed using such measurements made at several locations following irradiation with a Q-switched Nd:YAG (λ=1064nm) laser pulse. Our system is based on a modified Mach–Zehnder interferometer that measures surface displacement with a temporal resolution of 4ns and a displacement sensitivity of 0.3nm. Images formed from data sets acquired from several highly scattering tissue phantoms provide better than 200μm resolution and show great promise for high-resolution noninvasive imaging of heterogeneous tissues at depths approaching 1cm.

[1]  R. Kruger,et al.  Photoacoustic ultrasound (PAUS)--reconstruction tomography. , 1995, Medical physics.

[2]  Vasan Venugopalan,et al.  Optoacoustic tomography using time-resolved interferometric detection of surface displacement. , 2003, Journal of biomedical optics.

[3]  Alexander A. Oraevsky,et al.  Optoacoustic tomography: New modality of laser diagnostic systems , 2003 .

[4]  K. P. Köstli,et al.  Two-dimensional photoacoustic imaging by use of Fourier-transform image reconstruction and a detector with an anisotropic response. , 2003, Applied optics.

[5]  Robert A Kruger,et al.  Thermoacoustic molecular imaging of small animals. , 2003, Molecular imaging.

[6]  Martin Frenz,et al.  Real-time optoacoustic imaging using a Schlieren transducer , 2002 .

[7]  Vasan Venugopalan,et al.  Optoacoustic determination of optical attenuation depth using interferometric detection. , 2003, Journal of biomedical optics.

[8]  Martin Frenz,et al.  Optical method for two-dimensional ultrasonic detection , 1999 .

[9]  Minghua Xu,et al.  Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment. , 2002, Medical physics.

[10]  H. Weber,et al.  Optoacoustic imaging using a three-dimensional reconstruction algorithm , 2001 .

[11]  S. Jacques,et al.  Iterative reconstruction algorithm for optoacoustic imaging. , 2002, The Journal of the Acoustical Society of America.

[12]  Heinz Schmidt-Kloiber,et al.  Light distribution measurements in absorbing materials by optical detection of laser‐induced stress waves , 1996 .

[13]  B. Mikic,et al.  Measurement of tissue absorption coefficients by use of interferometric photothermal spectroscopy. , 1999, Applied optics.

[14]  Wiendelt Steenbergen,et al.  Analysis of three-dimensional photoacoustic imaging of a vascular tree in vitro , 2003 .

[15]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[16]  F. D. de Mul,et al.  Image reconstruction for photoacoustic scanning of tissue structures. , 2000, Applied optics.

[17]  H Schmidt-Kloiber,et al.  Optoacoustic tomography: time-gated measurement of pressure distributions and image reconstruction. , 2001, Applied optics.