Large-scale genomics unveils the genetic architecture of psychiatric disorders
暂无分享,去创建一个
Peter M Visscher | Matthew C Keller | Naomi R Wray | Jacob Gratten | P. Visscher | N. Wray | M. Keller | J. Gratten
[1] Major Depressive,et al. A mega-analysis of genome-wide association studies for major depressive disorder , 2016 .
[2] M. Daly,et al. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis , 2013, The Lancet.
[3] Kenny Q. Ye,et al. Strong Association of De Novo Copy Number Mutations with Autism , 2007, Science.
[4] Alexander Hoischen,et al. Prioritization of neurodevelopmental disease genes by discovery of new mutations , 2014, Nature Neuroscience.
[5] R. Handsaker,et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder , 2012, Molecular Psychiatry.
[6] C. Gillberg,et al. The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. , 2010, The American journal of psychiatry.
[7] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[8] Simon C. Potter,et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.
[9] J. Sebat,et al. High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia , 2011, Neuron.
[10] Kenny Q. Ye,et al. De Novo Gene Disruptions in Children on the Autistic Spectrum , 2012, Neuron.
[11] Alan S. Brown,et al. Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia. , 2006, Schizophrenia bulletin.
[12] M. Swash,et al. Controversies and priorities in amyotrophic lateral sclerosis , 2013, The Lancet Neurology.
[13] Nick C Fox,et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.
[14] Esben Agerbo,et al. Bipolar disorder, schizoaffective disorder, and schizophrenia overlap: a new comorbidity index. , 2009, The Journal of clinical psychiatry.
[15] Benjamin D. Greenberg,et al. Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture , 2013, PLoS genetics.
[16] K. Kendler,et al. Incidence of cancer in patients with schizophrenia and their first-degree relatives: a population-based study in Sweden. , 2013, Schizophrenia bulletin.
[17] H. Hakonarson,et al. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa , 2011, Molecular Psychiatry.
[18] 真田 昌. 骨髄異形成症候群のgenome-wide analysis , 2013 .
[19] P. Sullivan,et al. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. , 2003, Archives of general psychiatry.
[20] Jun S. Liu,et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery , 2013 .
[21] Neda Jahanshad,et al. Whole-genome analyses of whole-brain data: working within an expanded search space , 2014, Nature Neuroscience.
[22] L. Cardon,et al. Use of genome-wide association studies for drug repositioning , 2012, Nature Biotechnology.
[23] J. Sebat,et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia , 2011, Nature.
[24] N. Craddock,et al. Genome-wide association studies: a primer , 2009, Psychological Medicine.
[25] Tanya M. Teslovich,et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.
[26] J. Barendregt,et al. Global burden of disease , 1997, The Lancet.
[27] J. Ott,et al. Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.
[28] Guoping Feng,et al. Genome-scale neurogenetics: methodology and meaning , 2014, Nature Neuroscience.
[29] Jianxin Shi,et al. Common variants on chromosome 6p22.1 are associated with schizophrenia , 2009, Nature.
[30] P. Visscher,et al. Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia. , 2013, Schizophrenia bulletin.
[31] P. Visscher,et al. Five years of GWAS discovery. , 2012, American journal of human genetics.
[32] L. Petersen,et al. A comprehensive assessment of parental age and psychiatric disorders. , 2014, JAMA psychiatry.
[33] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[34] T. Insel,et al. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? , 2012, Molecular Psychiatry.
[35] M. Keshavan. Faculty Opinions recommendation of Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. , 2014 .
[36] Kathryn Roeder,et al. Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls , 2013, PLoS genetics.
[37] P M Visscher,et al. Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses , 2012, Molecular Psychiatry.
[38] B. Crespi,et al. Comparative genomics of autism and schizophrenia , 2010, Proceedings of the National Academy of Sciences.
[39] M. Daly,et al. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants , 2008, Genetic epidemiology.
[40] D. Altshuler,et al. Validating therapeutic targets through human genetics , 2013, Nature Reviews Drug Discovery.
[41] Jianxin Shi,et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs , 2013, Nature Genetics.
[42] W. G. Hill,et al. Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits , 2008, PLoS genetics.
[43] Michael F. Walker,et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism , 2012, Nature.
[44] S. Levy,et al. De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia , 2012, Nature Genetics.
[45] P. Visscher,et al. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. , 2013, American journal of human genetics.
[46] P. Visscher,et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.
[47] 鮫島 浩,et al. Population-based study からみた神経予後不良因子の検討 , 2009 .
[48] Susanne Walitza,et al. Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3 , 2012, The American journal of psychiatry.
[49] E. Banks,et al. De novo mutations in schizophrenia implicate synaptic networks , 2014, Nature.
[50] A. Eyre-Walker. Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. , 2010, Proceedings of the National Academy of Sciences of the United States of America.
[51] Matthew C Keller,et al. A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. , 2011, The American journal of psychiatry.
[52] H. Stefánsson,et al. Supplementary webappendix , 2018 .
[53] P. Visscher,et al. Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease , 2013, Nature Genetics.
[54] Jianxin Shi,et al. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. , 2011, The American journal of psychiatry.
[55] Jun Li,et al. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome‐wide association study of both common and rare variants , 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[56] M. King,et al. Genetic Heterogeneity in Human Disease , 2010, Cell.
[57] Naomi R. Wray,et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis , 2012, Human molecular genetics.
[58] R. Reading,et al. Diagnostic exome sequencing in persons with severe intellectual disability , 2013 .
[59] Boris Yamrom,et al. Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders , 2011, Neuron.
[60] Bok-Ghee Han,et al. Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans , 2013, PLoS genetics.
[61] Ayellet V. Segrè,et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.
[62] M. Lynch,et al. Genetics and Analysis of Quantitative Traits , 1996 .
[63] Bradley P. Coe,et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations , 2012, Nature.
[64] P. Visscher,et al. Sporadic cases are the norm for complex disease , 2010, European Journal of Human Genetics.
[65] Eric S. Lander,et al. A polygenic burden of rare disruptive mutations in schizophrenia , 2014, Nature.
[66] M. Daly,et al. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.
[67] T. Suppes,et al. Dimensions and the psychosis phenotype , 2007, International journal of methods in psychiatric research.
[68] G. Miller,et al. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? , 2006, The Behavioral and brain sciences.
[69] Joseph A. Gogos,et al. Strong association of de novo copy number mutations with sporadic schizophrenia , 2008, Nature Genetics.
[70] Anders D. Børglum,et al. Genome-wide association study identifies five new schizophrenia loci , 2011, Nature Genetics.
[71] Michael Wigler,et al. Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses , 2011, Neuron.
[72] N. Wray,et al. Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes , 2012, European Journal of Human Genetics.
[73] L. DeLisi,et al. Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14–18, 2012 , 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[74] Vladimir Makarov,et al. Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism , 2013, Proceedings of the National Academy of Sciences.
[75] K. Kendler,et al. The risk for psychiatric disorders in relatives of schizophrenic and control probands: a comparison of three independent studies , 1997, Psychological Medicine.
[76] David C. Wilson,et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.
[77] Christian Gilissen,et al. Diagnostic exome sequencing in persons with severe intellectual disability. , 2012, New England Journal of Medicine.
[78] Lilia M. Iakoucheva,et al. Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation , 2012, Cell.
[79] N. Wray,et al. Using Summary Data from the Danish National Registers to Estimate Heritabilities for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder , 2012, Front. Gene..
[80] M. Owen,et al. Genetics of schizophrenia , 2005, Current Opinion in Behavioral Sciences.
[81] L. Petersen,et al. Paternal age at birth of first child and risk of schizophrenia. , 2011, The American journal of psychiatry.
[82] J. Sebat,et al. Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders. , 2009, Trends in genetics : TIG.
[83] Simon C. Potter,et al. Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia , 2013, Nature Genetics.
[84] R. Kotov,et al. Diagnostic shifts during the decade following first admission for psychosis. , 2011, The American journal of psychiatry.
[85] Tyrone D. Cannon,et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study , 2009, The Lancet.
[86] P. Visscher,et al. Common SNPs explain a large proportion of heritability for human height , 2011 .
[87] Evan T. Geller,et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders , 2012, Nature.
[88] N. Wray,et al. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned , 2010, Molecular Psychiatry.
[89] Patrick F Sullivan,et al. The Psychiatric GWAS Consortium: Big Science Comes to Psychiatry , 2010, Neuron.
[90] P. Visscher,et al. Estimating missing heritability for disease from genome-wide association studies. , 2011, American journal of human genetics.
[91] Sang Hong Lee,et al. Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood , 2012, Bioinform..
[92] Ryan S. Lee,et al. Linking the SWI/SNF complex to prostate cancer , 2013, Nature Genetics.
[93] Kathryn Roeder,et al. Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism , 2011, Neuron.
[94] Angelica Ronald,et al. Autism spectrum disorders and autistic traits: A decade of new twin studies , 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[95] S Purcell,et al. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia , 2011, Molecular Psychiatry.
[96] Patrick F. Sullivan,et al. Don't give up on GWAS , 2012, Molecular Psychiatry.