A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma
暂无分享,去创建一个
Webster K. Cavenee | John B. Thomas | W. Cavenee | F. Furnari | R. Read | John B. Thomas | Frank B. Furnari | Renee D. Read
[1] T. Orr-Weaver,et al. Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. , 2003, Annual review of genetics.
[2] R. Henkelman,et al. Identification of human brain tumour initiating cells , 2004, Nature.
[3] M. Freeman,et al. Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis , 2002, Nature Cell Biology.
[4] Roger A Hoskins,et al. The Carnegie Protein Trap Library: A Versatile Tool for Drosophila Developmental Studies , 2007, Genetics.
[5] R. Bodmer,et al. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. , 2006, Cell metabolism.
[6] K. Wallace,et al. The pan‐neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes , 2000, Genesis.
[7] M. Freeman,et al. Glial cell biology in Drosophila and vertebrates , 2006, Trends in Neurosciences.
[8] C. Klämbt,et al. Organization and Function of the Blood–Brain Barrier in Drosophila , 2008, The Journal of Neuroscience.
[9] Li Zhang,et al. Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma , 2006, Clinical Cancer Research.
[10] B. Dickson,et al. The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation , 2001, Cell.
[11] B. Edgar,et al. Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors. , 2005, Cold Spring Harbor symposia on quantitative biology.
[12] B. Dickson,et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila , 2007, Nature.
[13] D. Prober,et al. Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. , 2002, Genes & development.
[14] P. Sicinski,et al. Cell Cycle Progression without Cyclin D-CDK4 and Cyclin D-CDK6 Complexes , 2005, Cell cycle.
[15] A. Teleman,et al. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. , 2008, Cell metabolism.
[16] T. P. Neufeld,et al. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila , 2002, Genesis.
[17] Webster K. Cavenee,et al. Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development , 2008, Cancer cell.
[18] T. Igaki,et al. Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila , 2006, Current Biology.
[19] P. Pandolfi,et al. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. , 2005, Neoplasia.
[20] D. Busam,et al. An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2008, Science.
[21] E. Hafen,et al. The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth. , 1996, The EMBO journal.
[22] L. Chin,et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. , 2007, Genes & development.
[23] N. Perrimon,et al. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.
[24] Nancy M Bonini,et al. Drosophila as a model for human neurodegenerative disease. , 2005, Annual review of genetics.
[25] R. DePinho,et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. , 2002, Cancer cell.
[26] C. Strambi,et al. Decreasing Glutamate Buffering Capacity Triggers Oxidative Stress and Neuropil Degeneration in the Drosophila Brain , 2004, Current Biology.
[27] Ethan Bier,et al. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins , 2002, Expert opinion on therapeutic targets.
[28] G M Rubin,et al. Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. , 1998, Development.
[29] P. Salvaterra,et al. Functional Analysis and Tissue‐Specific Expression of Drosophila Na+,K+‐ATPase Subunits , 1998, Journal of neurochemistry.
[30] I. Hariharan,et al. A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis , 1996, Cell.
[31] Yan Geng,et al. Requirement for CDK4 kinase function in breast cancer. , 2006, Cancer cell.
[32] B. Calvi,et al. Developmental and cell cycle regulation of the Drosophila histone locus body. , 2007, Molecular biology of the cell.
[33] Joseph Gera,et al. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. , 2007, Cancer research.
[34] Gerald C. Chu,et al. P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation , 2008, Nature.
[35] Eric C. Holland,et al. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice , 2000, Nature Genetics.
[36] I. Rebay,et al. Signal integration during development: Insights from the Drosophila eye , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.
[37] Junhyong Kim,et al. Unwrapping Glial Biology Gcm Target Genes Regulating Glial Development, Diversification, and Function , 2003, Neuron.
[38] S. Shibata,et al. Expression of the Ets-1 proto-oncogene correlates with malignant potential in human astrocytic tumors. , 1999, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[39] D. Bohmann,et al. JNK‐ and Fos‐regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila , 2006, The EMBO journal.
[40] I. Hariharan,et al. The Drosophila F Box Protein Archipelago Regulates dMyc Protein Levels In Vivo , 2004, Current Biology.
[41] J. Cerón,et al. Segregation of postembryonic neuronal and glial lineages inferred from a mosaic analysis of the Drosophila larval brain , 2007, Mechanisms of Development.
[42] Marion Müller-Borg,et al. Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling , 2005, Development.
[43] M. Stern,et al. Phosphatidylinositol 3-Kinase and Akt Nonautonomously Promote Perineurial Glial Growth in Drosophila Peripheral Nerves , 2007, The Journal of Neuroscience.
[44] I. Hariharan,et al. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. , 2006, Annual review of genetics.
[45] David M Sabatini,et al. Defining the role of mTOR in cancer. , 2007, Cancer cell.
[46] T. P. Neufeld,et al. Coordination of Growth and Cell Division in the Drosophila Wing , 1998, Cell.
[47] C. Rickert,et al. The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster. , 1995, Development.
[48] Stella Pelengaris,et al. c-MYC: more than just a matter of life and death , 2002, Nature Reviews Cancer.
[49] K. Mechtler,et al. Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells , 2006, Cell.
[50] N E Baker,et al. Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. , 1999, Developmental biology.
[51] Eric C. Holland,et al. Mouse Models of Brain Tumors and Their Applications in Preclinical Trials , 2006, Clinical Cancer Research.
[52] Joshua M. Korn,et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2008, Nature.
[53] D. Prober,et al. Ras1 Promotes Cellular Growth in the Drosophila Wing , 2000, Cell.
[54] John Tyler Bonner,et al. Morphogenesis , 1965, Cell.
[55] R. DePinho,et al. Malignant glioma: genetics and biology of a grave matter. , 2001, Genes & development.
[56] T. Schüpbach,et al. Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. , 1997, Development.
[57] V. Hartenstein,et al. Morphogenesis and proliferation of the larval brain glia in Drosophila. , 2005, Developmental biology.
[58] Christian Klämbt,et al. The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS , 1994, Cell.
[59] A. Shearn,et al. Drosophila brain tumor metastases express both neuronal and glial cell type markers. , 2007, Developmental biology.
[60] Liqun Luo,et al. Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis , 1999, Neuron.
[61] Hongye Liu,et al. Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma , 2007, Neuron.
[62] E. Hafen,et al. Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity. , 2001, Development.
[63] S. Cohen,et al. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. , 2007, Genes & development.
[64] E. Caussinus,et al. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster , 2005, Nature Genetics.
[65] Bassem A. Hassan,et al. atonal Regulates Neurite Arborization but Does Not Act as a Proneural Gene in the Drosophila Brain , 2000, Neuron.
[66] I. Mellinghoff,et al. AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression* , 2004, Journal of Biological Chemistry.
[67] I. Salecker,et al. glial cells missing and gcm2 Cell Autonomously Regulate Both Glial and Neuronal Development in the Visual System of Drosophila , 2005, Neuron.
[68] E. Petricoin,et al. Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype , 2003, Proceedings of the National Academy of Sciences of the United States of America.