Blinking and corneal sensitivity

Abstract. We have investigated the relationship between corneal sensitivity and blinking patterns. Using a group of 9 young normal subjects, measurements were made of blink patterns, central and peripheral corneal sensitivity and lid margin sensitivity both before and after use of topical corneal anaesthetic, proxymetacaine hydrochloride (Alcaine). Blink patterns were recorded through concealed filming and were later analysed in terms of blink frequency and the type of blinks (proportion of complete, incomplete, twitch and forced blinks). Blink rate was significantly lower following anaesthetic administration, but the relative proportion of blink types remained unchanged. We speculate that one of the factors responsible for normal involuntary blinks is the imminent break‐up of the tear film which is sensed by the cornea.

[1]  K. M. Michels,et al.  Muscular tension and the human blink rate. , 1957, Journal of experimental psychology.

[2]  J. V. van Best,et al.  Corneal epithelial permeability after instillation of ophthalmic solutions containing local anaesthetics and preservatives. , 1988, Current eye research.

[3]  M. Millodot.  Psychophysical scaling of corneal sensitivity , 1968 .

[4]  F. Holly,et al.  Formation and rupture of the tear film. , 1973, Experimental eye research.

[5]  M. Millodot.  A REVIEW OF RESEARCH ON THE SENSITIVITY OF THE CORNEA * , 1984, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[6]  M. Abelson,et al.  A tentative mechanism for inferior punctate keratopathy. , 1977, American journal of ophthalmology.

[7]  M A Lemp,et al.  Factors affecting tear film breakup in normal eyes. , 1973, Archives of ophthalmology.

[8]  J. Ong,et al.  VARIATION IN BLINK RATE ASSOCIATED WITH CONTACT LENS WEAR AND TASK DIFFICULTY* , 1971, American journal of optometry and archives of American Academy of Optometry.

[9]  R. Beuerman,et al.  Corneal pain evoked by thermal stimulation , 1979, Pain.

[10]  R. Fullard,et al.  Cell sloughing with proparacaine. , 1988, Journal of the American Optometric Association.

[11]  M. Doane.  Interactions of eyelids and tears in corneal wetting and the dynamics of the normal human eyeblink. , 1980, American journal of ophthalmology.

[12]  Frank K. Moss,et al.  The eyelid reflex as a criterion of ocular fatigue , 1937 .

[13]  B. Holden,et al.  Effects of cataract surgery on corneal function. , 1982, Investigative ophthalmology & visual science.

[14]  K A Polse,et al.  Changes in Tear Flow Accompanying Aging , 1978, American journal of optometry and physiological optics.

[15]  K. Polse,et al.  Peripheral corneal staining accompanying contact lens wear. , 1969, Journal of the American Optometric Association.

[16]  M. Collins,et al.  Blinking Patterns in Soft Contact Lens Wearers Can Be Altered with Training , 1987, American journal of optometry and physiological optics.

[17]  M. Ruben,et al.  Keratoplasty sensitivity. , 1979, The British journal of ophthalmology.

[18]  N. Burstein.  Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. , 1980, Survey of ophthalmology.

[19]  Josephson Je,et al.  Corneal staining after instillation of topical anesthetic (SSII). , 1988 .

[20]  L. Carney,et al.  THE NATURE OF NORMAL BLINKING PATTERNS , 1982, Acta ophthalmologica.

[21]  J. Prause,et al.  Relation between blink frequency and break‐up time? , 1987, Acta ophthalmologica.

[22]  M. Millodot.  The influence of age onthe sensitivity of the cornea,. , 1977, Investigative ophthalmology & visual science.

[23]  E. Ruckenstein,et al.  Mechanism of Tear Film Rupture and Its Implications for Contact Lens Tolerance , 1985, American journal of optometry and physiological optics.

[24]  W. M. Lyle,et al.  POSSIBLE ADVERSE EFFECTS FROM LOCAL ANESTHETICS AND THE TREATMENT OF THESE REACTIONS* , 1975, American journal of optometry and physiological optics.

[25]  P. P. Lele,et al.  The relationship between neurohistology and corneal sensibility. , 1956, Brain : a journal of neurology.