Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

CHOP turns on ERO1-α to release calcium via IP3R and trigger cell death in response to ER stress.

[1]  Mark E. Anderson,et al.  Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. , 2009, The Journal of clinical investigation.

[2]  D. Ron,et al.  Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. , 2009, Cell metabolism.

[3]  R. Rizzuto,et al.  Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. , 2008, Molecular cell.

[4]  John Calvin Reed,et al.  Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities , 2008, Nature Reviews Drug Discovery.

[5]  Alexander S. Banks,et al.  Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress , 2008, Diabetes.

[6]  Subramaniam Pennathur,et al.  Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. , 2008, The Journal of clinical investigation.

[7]  G. Wagner,et al.  Effects of Redox Potential and Ca2+ on the Inositol 1,4,5-Trisphosphate Receptor L3-1 Loop Region , 2008, Journal of Biological Chemistry.

[8]  R. Virmani,et al.  Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo , 2008, Circulation.

[9]  G. Kroemer,et al.  Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis , 2008, Oncogene.

[10]  R. Kaufman,et al.  The endoplasmic reticulum and the unfolded protein response. , 2007, Seminars in cell & developmental biology.

[11]  Tomomi Gotoh,et al.  ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim , 2007, Cell.

[12]  Y. Aggoun,et al.  Obesity, Metabolic Syndrome, and Cardiovascular Disease , 2007, Pediatric Research.

[13]  Douglas T. Golenbock,et al.  Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages , 2006, Proceedings of the National Academy of Sciences.

[14]  G. Hajnóczky,et al.  Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. , 2006, Cell calcium.

[15]  J. Kuratsu,et al.  CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation , 2006, FEBS letters.

[16]  D. Accili,et al.  Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. , 2006, Cell metabolism.

[17]  R. Flavell,et al.  Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor , 2005, The Journal of cell biology.

[18]  K. Mikoshiba,et al.  Subtype-Specific and ER Lumenal Environment-Dependent Regulation of Inositol 1,4,5-Trisphosphate Receptor Type 1 by ERp44 , 2005, Cell.

[19]  D. Ron,et al.  CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. , 2004, Genes & development.

[20]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[21]  J. Freed,et al.  Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids , 2004, Journal of Biological Chemistry.

[22]  P. Camacho,et al.  Ca2+-dependent redox modulation of SERCA 2b by ERp57 , 2004, The Journal of cell biology.

[23]  S. Snyder,et al.  Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis , 2003, Nature Cell Biology.

[24]  J. Hamilton,et al.  The Phenotype of Inflammatory Macrophages Is Stimulus Dependent: Implications for the Nature of the Inflammatory Response1 , 2003, The Journal of Immunology.

[25]  George Kuriakose,et al.  The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages , 2003, Nature Cell Biology.

[26]  Kiyoshi Inoue,et al.  ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. , 2002, Genes & development.

[27]  Masataka Mori,et al.  Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. , 2002, The Journal of clinical investigation.

[28]  P. M. Yao,et al.  Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway* , 2001, The Journal of Biological Chemistry.

[29]  P. M. Yao,et al.  Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway* , 2000, The Journal of Biological Chemistry.

[30]  Junying Yuan,et al.  Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β , 2000, Nature.

[31]  D. Linden,et al.  Inositol-1,4,5-trisphosphate receptor-mediated Ca mobilization is not required for cerebellar long-term depression in reduced preparations. , 1998, Journal of neurophysiology.

[32]  Xiaozhong Wang,et al.  CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. , 1998, Genes & development.

[33]  A. Marks,et al.  T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis , 1997, Molecular and cellular biology.

[34]  E. Pennisi.  Linker Histones, DNA's Protein Custodians, Gain New Respect , 1996, Science.

[35]  S. Snyder,et al.  Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor , 1996, Science.

[36]  R. Morimoto,et al.  Complex regulation of heat shock- and glucose-responsive genes in human cells , 1988, Molecular and cellular biology.

[37]  P. Blackmore,et al.  Characterization of responses of isolated rat hepatocytes to ATP and ADP. , 1985, The Journal of biological chemistry.

[38]  P. Camacho,et al.  Ca 2-dependent redox modulation of SERCA 2 b by ERp 57 , 2022 .