论文信息 - Amelioration of Cardiac Morphology and Function in Type 1 Diabetic Patients With Sustained Success of Pancreas Transplant Alone

Amelioration of Cardiac Morphology and Function in Type 1 Diabetic Patients With Sustained Success of Pancreas Transplant Alone

Pancreas transplant alone (PTA) is coming of age for the treatment of selected type 1 diabetic (T1D) patients (1). By restoring endogenous insulin secretion, it eliminates acute diabetes complications and may improve late microvascular complications (1,2). However, the impact of PTA on the recipient’s heart is largely unknown. Here, we report that successful PTA is associated with long-term amelioration of cardiac morphology and function. As of December 2013, 93 PTAs have been performed in our center, with 5-year patient and pancreas survival of 97 and 76%, respectively (2). Indications and contraindications for PTA, surgery, and immunosuppression were as previously reported (1,2). From this cohort, 30 consecutive successfully transplanted patients (males 50%; age 38 ± 8 years; BMI 24.0 ± 2.8 kg/m2; diabetes duration 25 ± 9 years; insulin dose 47 ± …

[1] U. Boggi,et al. Follow-up of secondary diabetic complications after pancreas transplantation , 2013, Current opinion in organ transplantation.

[2] J. Skupień,et al. The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end stage renal disease , 2012, Kidney international.

[3] U. Boggi,et al. Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients1 , 2003, Transplantation.

[4] R. MacIsaac,et al. Prevalence, predictors and evolution of echocardiographically defined cardiac abnormalities in adults with type 1 diabetes: an observational cohort study. , 2014, Journal of diabetes and its complications.