Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin

[1]  B. Seliger,et al.  Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies? , 1998, Cancer research.

[2]  M. Sy,et al.  Down-regulation of the transporter for antigen presentation, proteasome subunits, and class I major histocompatibility complex in tumor cell lines. , 1998, Cancer research.

[3]  P. Cresswell,et al.  Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220. , 1998, Immunity.

[4]  Robert Tampé,et al.  Down‐regulation of the MHC class I antigen‐processing machinery after oncogenic transformation of murine fibroblasts , 1998, European journal of immunology.

[5]  R. Tampé,et al.  A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. , 1997, Science.

[6]  U. Hellman,et al.  Cloning and functional characterization of a subunit of the transporter associated with antigen processing. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[7]  B. Seliger,et al.  TAP off--tumors on. , 1997, Immunology today.

[8]  P. Cresswell,et al.  Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. , 1996, Immunity.

[9]  R. Tampé,et al.  Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[10]  J. Monaco,et al.  Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit. , 1996, Journal of immunology.

[11]  A. Harris,et al.  Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer. , 1996, British Journal of Cancer.

[12]  P. Kloetzel,et al.  The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro(*) , 1995, The Journal of Biological Chemistry.

[13]  A. Rivett,et al.  LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes , 1995, Current Biology.

[14]  R. Obst,et al.  Analysis of the fine specificity of rat, mouse and human TAP peptide transporters , 1995, European journal of immunology.

[15]  S. Beck,et al.  Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter , 1995, The Journal of experimental medicine.

[16]  J. Trowsdale,et al.  Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins , 1994, Current Biology.

[17]  K. Rajewsky,et al.  MHC class I expression in mice lacking the proteasome subunit LMP-7. , 1994, Science.

[18]  C. Meijer,et al.  Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas , 1994, The Journal of experimental medicine.

[19]  J. Neefjes,et al.  Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. , 1993, Science.

[20]  J. Yewdell,et al.  Identification of human cancers deficient in antigen processing , 1993, The Journal of experimental medicine.

[21]  S. Tonegawa,et al.  TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells , 1992, Cell.

[22]  P. Cresswell,et al.  Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. , 1992, Journal of immunology.

[23]  J. Neefjes,et al.  Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation , 1992, Nature.

[24]  Günter J. Hämmerling,et al.  Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex , 1991, Nature.

[25]  R. Demars,et al.  A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway , 1990, Nature.

[26]  S. Beck,et al.  Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters , 1990, Nature.

[27]  Hans-Georg Rammensee,et al.  Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells , 1990, Nature.

[28]  Hidde L. Ploegh,et al.  Empty MHC class I molecules come out in the cold , 1990, Nature.

[29]  R M Zinkernagel,et al.  MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. , 1979, Advances in immunology.