Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice.

[1]  Zhishan Cui,et al.  An osteoarthritis subtype characterized by synovial lipid metabolism disorder and fibroblast-like synoviocyte dysfunction , 2022, Journal of orthopaedic translation.

[2]  H. Weinans,et al.  Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice. , 2021, Osteoarthritis and cartilage.

[3]  M. Oosting,et al.  Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein , 2020, Journal of Molecular Medicine.

[4]  Y. Wang,et al.  Association between statin use and incidence or progression of osteoarthritis: Meta-analysis of observational studies. , 2020, Osteoarthritis and cartilage.

[5]  H. Weinans,et al.  High-Fat Feeding Primes The Mouse Knee Joint To Develop Osteoarthritis And Pathologic Infrapatellar Fat Pad Changes After Surgically Induced Injury. , 2020, Osteoarthritis and cartilage.

[6]  A. Orekhov,et al.  The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation , 2020, International journal of molecular sciences.

[7]  J. Jukema,et al.  Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice[S] , 2019, Journal of Lipid Research.

[8]  C. Cooper,et al.  Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study , 2019, Arthritis care & research.

[9]  L. Joosten,et al.  Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. , 2019, Cell metabolism.

[10]  L. Joosten,et al.  Therapeutic targeting of trained immunity , 2019, Nature Reviews Drug Discovery.

[11]  Won Kim,et al.  Association between metabolic syndrome and knee osteoarthritis: A cross-sectional nationwide survey study. , 2019, Journal of rehabilitation medicine.

[12]  J. Jukema,et al.  The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis , 2019, Journal of diabetes research.

[13]  R. Glynn,et al.  Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study , 2018, Arthritis care & research.

[14]  Odyssey Outcomes Investigators.  Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome , 2018 .

[15]  H. Brenner,et al.  Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement , 2018, Scientific Reports.

[16]  M. Oosting,et al.  Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming , 2018, Cell.

[17]  G. Herrero-Beaumont,et al.  Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis , 2017, Arthritis Research & Therapy.

[18]  P. Arasteh,et al.  Relationship between metabolic syndrome and osteoarthritis: The Fasa Osteoarthritis Study. , 2017, Diabetes & metabolic syndrome.

[19]  A. Wolk,et al.  Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies. , 2017, Osteoarthritis and cartilage.

[20]  W. B. van den Berg,et al.  WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis. , 2017, Osteoarthritis and cartilage.

[21]  H. Weinans,et al.  Metabolic dysregulation accelerates injury‐induced joint degeneration, driven by local inflammation; an in vivo rat study , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[22]  A. Märtson,et al.  Metabolic factors and oxidative stress in osteoarthritis: a case–control study , 2017, Scandinavian journal of clinical and laboratory investigation.

[23]  T. Spector,et al.  Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study , 2017, Scientific Reports.

[24]  P. Lehenkari,et al.  Subchondral bone histology and grading in osteoarthritis , 2017, PloS one.

[25]  Yin Xiao,et al.  Protective effects of mitochondria‐targeted antioxidants and statins on cholesterolinduced osteoarthritis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[26]  K. Croce,et al.  High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis. , 2016, Osteoarthritis and cartilage.

[27]  R. Xavier,et al.  Trained immunity: A program of innate immune memory in health and disease , 2016, Science.

[28]  R. Jaarsma,et al.  Metabolic syndrome and components exacerbate osteoarthritis symptoms of pain, depression and reduced knee function. , 2016, Annals of translational medicine.

[29]  J. Jukema,et al.  Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials. , 2015, European journal of pharmacology.

[30]  Jennifer G. Robinson,et al.  Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. , 2015, The New England journal of medicine.

[31]  J. Jukema,et al.  Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin[S] , 2014, Journal of Lipid Research.

[32]  L. Joosten,et al.  Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[33]  L. Havekes,et al.  APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome , 2014, Diabetes, obesity & metabolism.

[34]  Yuan-Lin Guo,et al.  Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease. , 2014, Atherosclerosis.

[35]  L. Joosten,et al.  Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis , 2013, Arthritis Research & Therapy.

[36]  E. Pieterman,et al.  Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice—a translational model for atherosclerosis , 2013, Annals of the rheumatic diseases.

[37]  D. Riddle,et al.  Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis , 2012, Annals of the rheumatic diseases.

[38]  S. Goldring,et al.  Osteoarthritis: a disease of the joint as an organ. , 2012, Arthritis and rheumatism.

[39]  T. Griffin,et al.  Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. , 2012, Arthritis and rheumatism.

[40]  A. Hofman,et al.  Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study , 2011, Annals of the rheumatic diseases.

[41]  R. Puenpatom,et al.  Increased Prevalence of Metabolic Syndrome in Individuals with Osteoarthritis: An Analysis of NHANES III Data , 2009, Postgraduate medicine.

[42]  W. B. van den Berg,et al.  Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation. , 2007, Arthritis and rheumatism.

[43]  T. Kooistra,et al.  Mouse models for atherosclerosis and pharmaceutical modifiers. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[44]  S. Jimenez,et al.  Osteoarthritis cartilage histopathology: grading and staging. , 2006, Osteoarthritis and cartilage.

[45]  R. Frants,et al.  Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice. , 1996, The Journal of clinical investigation.

[46]  E. Vollmer,et al.  Expression and complex formation of S100-like proteins MRP8 and MRP14 by macrophages during renal allograft rejection. , 1994, Transplantation.

[47]  H. Weinans,et al.  Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought. , 2018, Osteoarthritis and cartilage.