Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival

[1]  Hans Clevers,et al.  Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.

[2]  R. Richardson,et al.  Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation , 2008, Nature.

[3]  Keith L Black,et al.  Hedgehog Signaling Regulates Brain Tumor‐Initiating Cell Proliferation and Portends Shorter Survival for Patients with PTEN‐Coexpressing Glioblastomas , 2008, Stem cells.

[4]  K. Wong,et al.  Direct Orthotopic Transplantation of Fresh Surgical Specimen Preserves CD133+ Tumor Cells in Clinically Relevant Mouse Models of Medulloblastoma and Glioma , 2008, Stem cells.

[5]  Hua Tian,et al.  A paracrine requirement for hedgehog signalling in cancer , 2008, Nature.

[6]  Peter Canoll,et al.  Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. , 2008, Neurosurgery.

[7]  R. Arceci.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response , 2008 .

[8]  Mark Shackleton,et al.  Efficient tumour formation by single human melanoma cells , 2008 .

[9]  A. Joe,et al.  Oncogene addiction. , 2008, Cancer research.

[10]  A. Olivi,et al.  Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma , 2007, Stem cells.

[11]  M. Scott,et al.  Patching the gaps in Hedgehog signalling , 2007, Nature Cell Biology.

[12]  M. K. Cooper,et al.  Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells , 2007, Oncogene.

[13]  Aleksandar Dakic,et al.  Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells , 2007, Science.

[14]  B. Scheithauer,et al.  The 2007 WHO classification of tumours of the central nervous system , 2007, Acta Neuropathologica.

[15]  Hongye Liu,et al.  Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma , 2007, Neuron.

[16]  P. Sánchez,et al.  HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity , 2007, Current Biology.

[17]  Mark W. Dewhirst,et al.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response , 2006, Nature.

[18]  G. Broggi,et al.  Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells , 2006, Nature.

[19]  K. Black,et al.  Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma , 2006, Molecular Cancer.

[20]  Lee L. Rubin,et al.  Targeting the Hedgehog pathway in cancer , 2006, Nature Reviews Drug Discovery.

[21]  Irving L Weissman,et al.  Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. , 2006, Cancer research.

[22]  M. Scott,et al.  Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration , 2006, Proceedings of the National Academy of Sciences.

[23]  Eric C. Holland,et al.  Mouse Models of Brain Tumors and Their Applications in Preclinical Trials , 2006, Clinical Cancer Research.

[24]  Yuri Kotliarov,et al.  Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. , 2006, Cancer cell.

[25]  E. Maher,et al.  Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors. , 2006, Cancer research.

[26]  A. Joyner,et al.  In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog , 2005, Nature.

[27]  P. Sánchez,et al.  In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice , 2005, Mechanisms of Development.

[28]  M. Bibby,et al.  50 years of preclinical anticancer drug screening: empirical to target-driven approaches. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[29]  R. Henkelman,et al.  Identification of human brain tumour initiating cells , 2004, Nature.

[30]  A. Maitra,et al.  Urological Survey UROLOGICAL ONCOLOGY: PROSTATE CANCER Hedgehog Signalling in Prostate Regeneration, Neoplasia and Metastasis , 2005 .

[31]  H. Wichterle,et al.  Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists , 2002, Journal of biology.

[32]  Jussi Taipale,et al.  Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. , 2002, Genes & development.

[33]  Jussi Taipale,et al.  Small molecule modulation of Smoothened activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[34]  James M. Olson,et al.  Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade , 2002, Science.

[35]  G. Reifenberger,et al.  The WHO Classification of Tumors of the Nervous System , 2002, Journal of neuropathology and experimental neurology.

[36]  Andrew P. McMahon,et al.  Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node , 2001, Cell.

[37]  I. Weissman,et al.  Direct isolation of human central nervous system stem cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[38]  B. Scheithauer,et al.  Histopathology, classification, and grading of gliomas , 1995, Glia.