Effect of a single autologous cord blood infusion on beta‐cell and immune function in children with new onset type 1 diabetes: a non‐randomized, controlled trial

The application of autologous cord blood in children with type 1 diabetes has been found to be safe, but not to preserve beta‐cell function in a previous study, which, however, had not included a control group.

[1]  Michael Schlosser,et al.  Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. , 2011, Clinical chemistry.

[2]  D. Theriaque,et al.  Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide , 2011, Diabetes Care.

[3]  P. Bingley,et al.  Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies , 2010, Diabetologia.

[4]  A. Ziegler,et al.  Loss and Preservation of β-Cell Function: Two Treatment Regimes Targeting T or B Lymphocytes , 2010, Current diabetes reports.

[5]  Dandan Wang,et al.  Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. , 2010, Arthritis and rheumatism.

[6]  E. Gluckman,et al.  Pediatric related and unrelated cord blood transplantation for malignant diseases , 2009, Bone Marrow Transplantation.

[7]  E. Bonifacio,et al.  Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk , 2009, Diabetologia.

[8]  J. Taneera,et al.  Bone marrow transplantation stimulates pancreatic β−cell replication after tissue damage , 2009, Islets.

[9]  A. Green,et al.  Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study , 2009, The Lancet.

[10]  J. Buckner,et al.  The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells1 , 2008, The Journal of Immunology.

[11]  Mohamed H. Sayegh,et al.  Immunomodulation by Mesenchymal Stem Cells , 2008, Diabetes.

[12]  M. Atkinson,et al.  Autologous umbilical cord blood infusion for type 1 diabetes. , 2008, Experimental hematology.

[13]  Michael Schlosser,et al.  Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2 , 2008, Diabetologia.

[14]  S. Watt,et al.  Directed Sibling Cord Blood Banking for Transplantation: The 10‐Year Experience in the National Blood Service in England , 2007, Stem cells.

[15]  G. Klingensmith,et al.  ISPAD Clinical Practice Consensus Guidelines 2006–2007 , 2006, Pediatric diabetes.

[16]  B. Grubeck‐Loebenstein,et al.  Imbalance of regulatory T cells in human autoimmune diseases , 2006, Immunology.

[17]  B. Zinman,et al.  Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. , 2005, The New England journal of medicine.

[18]  M. Atkinson,et al.  Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. , 2005, Diabetes.

[19]  B. Levine,et al.  Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. , 2004, Blood.

[20]  Li Li,et al.  Bone marrow–derived stem cells initiate pancreatic regeneration , 2003, Nature Biotechnology.

[21]  M. Labopin,et al.  Relevance of bone marrow cell dose on allogeneic transplantation outcomes for patients with acute myeloid leukemia in first complete remission: results of a European survey. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  J Wagner,et al.  Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. , 2002, Blood.

[23]  S. Chevret,et al.  Association of CD34 cell dose with hematopoietic recovery, infections, and other outcomes after HLA-identical sibling bone marrow transplantation. , 2002, Blood.

[24]  A. Órfão,et al.  Clinical significance of CD34+ cell dose in long-term engraftment following autologous peripheral blood stem cell transplantation , 1999, Bone Marrow Transplantation.

[25]  E. Bonifacio,et al.  Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. , 1999, Diabetes.

[26]  Diabetes Control.  Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group. , 1994, The Journal of pediatrics.

[27]  M M Tai,et al.  A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves , 1994, Diabetes Care.

[28]  M. Peakman,et al.  T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review. , 2016, Journal of autoimmunity.

[29]  M. Peakman,et al.  Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. , 2005, Diabetes.