Lovastatin production: From molecular basis to industrial process optimization.
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[1] A. Abbas,et al. Lovastatin and (+)‐geodin production by Aspergillus terreus from crude glycerol , 2015 .
[2] Li Liu,et al. Design and in vitro evaluation of simvastatin-hydroxyapatite coatings by an electrochemical process on titanium surfaces. , 2014, Journal of biomedical nanotechnology.
[3] H. Mukhtar,et al. Upstream and Downstream Processing of Lovastatin by Aspergillus terreus , 2014, Cell Biochemistry and Biophysics.
[4] O. Haworth,et al. Modulation of Lung Immune Response , 2013, BioMed Research International.
[5] Carolina Chegwin-Angarita,et al. Evaluation of a method using high performance liquid chromatography with ultraviolet detection for the determination of statins in macromycetes of the genus Pleurotus cultivated by fermentation processes. , 2013, Talanta.
[6] M. Helmus,et al. Bioresorbable polystatin fourth-generation stents , 2013, Coronary artery disease.
[7] K. Radha,et al. A REVIEW: LOVASTATIN PRODUCTION AND APPLICATIONS , 2013 .
[8] J. Vederas,et al. LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. , 2013, Angewandte Chemie.
[9] U. Christians,et al. Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter. , 2013, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
[10] K. Rothman,et al. Statins may reduce femoral osteolysis in patients with total Hip arthroplasty , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[11] B. Nigović,et al. Simultaneous determination of lovastatin and citrinin in red yeast rice supplements by micellar electrokinetic capillary chromatography. , 2013, Food chemistry.
[12] Y. Goh,et al. Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii , 2013, BioMed research international.
[13] B. Kaufmann,et al. Noninvasive Ultrasound Molecular Imaging of the Effect of Statins on Endothelial Inflammatory Phenotype in Early Atherosclerosis , 2013, PloS one.
[14] L. Gómez-Quiroz,et al. Oxidative state in idiophase links reactive oxygen species (ROS) and lovastatin biosynthesis: differences and similarities in submerged- and solid-state fermentations. , 2013, Fungal biology.
[15] Y. Goh,et al. Lovastatin-Enriched Rice Straw Enhances Biomass Quality and Suppresses Ruminal Methanogenesis , 2013, BioMed research international.
[16] elwal,et al. Screening and Molecular Characterization of Natural Fungal Isolates Producing Lovastatin , 2013 .
[17] M. Bizukojć,et al. Effect of pH on biosynthesis of lovastatin and other secondary metabolites by Aspergillus terreus ATCC 20542. , 2012, Journal of biotechnology.
[18] Axel A. Brakhage,et al. Regulation of fungal secondary metabolism , 2012, Nature Reviews Microbiology.
[19] Y. Goh,et al. Lovastatin Production by Aspergillus terreus Using Agro-Biomass as Substrate in Solid State Fermentation , 2012, Journal of biomedicine & biotechnology.
[20] L. Žilnik,et al. Solvent extraction of lovastatin from a fermentation broth , 2012 .
[21] J. Mau,et al. Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia , 2012 .
[22] Paolo Carloni,et al. Advanced Computational Methods in Molecular Medicine , 2012, Journal of biomedicine & biotechnology.
[23] S. Ledakowicz,et al. Impact of bioreactor scale on lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture , 2012 .
[24] W. Mangunwardoyo,et al. Bioprospect of lovastatin in Aspergillus spp. from University of Indonesia Culture Collection (UICC) , 2012 .
[25] Robert E. Smith,et al. Fast screening of lovastatin in red yeast rice products by flow injection tandem mass spectrometry. , 2012, Journal of pharmaceutical and biomedical analysis.
[26] A. Ariff,et al. Nutritional Requirements for the Improvement of Growth and Sporulation of Several Strains of Monascus purpureus on Solid State Cultivation , 2011, Journal of biomedicine & biotechnology.
[27] A. Ariff,et al. Assessment of Monacolin in the Fermented Products Using Monascus purpureus FTC5391 , 2011, Journal of biomedicine & biotechnology.
[28] Shi-Weng Li,et al. Induction of a High-Yield Lovastatin Mutant of Aspergillus terreus by 12C6+ Heavy-Ion Beam Irradiation and the Influence of Culture Conditions on Lovastatin Production Under Submerged Fermentation , 2011, Applied biochemistry and biotechnology.
[29] T. Egawa,et al. The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals. , 2011, European journal of pharmacology.
[30] M. Bizukojć,et al. Lovastatin biosynthesis by Aspergillus terreus with the simultaneous use of lactose and glycerol in a discontinuous fed-batch culture. , 2011, Journal of biotechnology.
[31] Xingfeng Guo,et al. Accelerated solvent extraction of monacolin K from red yeast rice and purification by high-speed counter-current chromatography. , 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[32] I. Roy,et al. Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures , 2010, Applied Microbiology and Biotechnology.
[33] B. Panda,et al. Optimization of Fermentation Parameters for Higher Lovastatin Production in Red Mold Rice through Co-culture of Monascus purpureus and Monascus ruber , 2010 .
[34] A. Endo. A historical perspective on the discovery of statins , 2010, Proceedings of the Japan Academy. Series B, Physical and biological sciences.
[35] Xuejun Cao,et al. Enhancement of Lovastatin Production by Supplementing Polyketide Antibiotics to the Submerged Culture of Aspergillus terreus , 2010, Applied biochemistry and biotechnology.
[36] R. Singhal,et al. Response surface methodology for optimization of production of lovastatin by solid state fermentation , 2010, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
[37] J. Vederas,et al. Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase , 2009, Science.
[38] H. Kaur,et al. Screening and selection of lovastatin hyper-producing mutants of Aspergillus terreus using cyclic mutagenesis. , 2009, Acta microbiologica et immunologica Hungarica.
[39] G. Szakács,et al. High lovastatin production by Aspergillus terreus in solid-state fermentation on polyurethane foam: an artificial inert support. , 2009, Journal of bioscience and bioengineering.
[40] R. Singhal,et al. Supercritical fluid extraction of lovastatin from the wheat bran obtained after solid-state fermentation. , 2009 .
[41] S. Ledakowicz,et al. Physiological, morphological and kinetic aspects of lovastatin biosynthesis by Aspergillus terreus , 2009, Biotechnology journal.
[42] Xuejun Cao,et al. Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreus in chemically defined medium , 2009 .
[43] S. Ledakowicz,et al. Biosynthesis of lovastatin and (+)-geodin by Aspergillus terreus in batch and fed-batch culture in the stirred tank bioreactor☆ , 2008 .
[44] T. Stossel. The Discovery of Statins , 2008, Cell.
[45] Y. Chisti,et al. Lovastatin production by Aspergillus terreus in a two‐staged feeding operation , 2008 .
[46] A. Covarrubias,et al. Lovastatin biosynthetic genes of Aspergillus terreus are expressed differentially in solid-state and in liquid submerged fermentation , 2008, Applied Microbiology and Biotechnology.
[47] S. Ledakowicz,et al. Simultaneous biosynthesis of (+)-geodin by a lovastatin-producing fungus Aspergillus terreus. , 2007, Journal of biotechnology.
[48] Zhinan Xu,et al. Lovastatin production by Aspergillus terreus in solid-state fermentation , 2007 .
[49] Marcin Bizukojc,et al. A macrokinetic modelling of the biosynthesis of lovastatin by Aspergillus terreus. , 2007, Journal of biotechnology.
[50] Long-Shan T. Lai,et al. Effects of lactose and glucose on production of itaconic acid and lovastatin by Aspergillus terreus ATCC 20542. , 2007, Journal of bioscience and bioengineering.
[51] Yi Tang,et al. Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB , 2007, The FEBS journal.
[52] P. Srivastava,et al. A correlative evaluation of morphology and rheology ofAspergillus terreus during lovastatin fermentation , 2007 .
[53] J. Vederas,et al. Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase. , 2007, Organic letters.
[54] M. Ali,et al. Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology , 2007, Applied Microbiology and Biotechnology.
[55] Kenji Watanabe,et al. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. , 2006, Chemistry & biology.
[56] L. Hwang,et al. Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea. , 2006, Journal of chromatography. A.
[57] T. Pan,et al. Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. , 2006, Journal of AOAC International.
[58] Y. Chisti,et al. Effects of the sporulation conditions on the lovastatin production by Aspergillus terreus , 2006, Bioprocess and biosystems engineering.
[59] J. Bennett,et al. Fungal secondary metabolism — from biochemistry to genomics , 2005, Nature Reviews Microbiology.
[60] Yusuf Chisti,et al. Effects of pellet morphology on broth rheology in fermentations of Aspergillus terreus , 2005 .
[61] J. Gomes,et al. Lovastatin production by solid state fermentation using Aspergillus flavipes , 2005 .
[62] Teilin Wang,et al. The influence of culturing environments on lovastatin production by Aspergillus terreus in submerged cultures , 2005 .
[63] Y. Chisti,et al. Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus. , 2005, Journal of biotechnology.
[64] Y. Chisti,et al. Rapid screening of Aspergillus terreus mutants for overproduction of lovastatin , 2005 .
[65] Baojun Xu,et al. Enhanced lovastatin production by solid state fermentation ofMonascus ruber , 2005 .
[66] Y. Chisti,et al. Fermentation optimization for the production of lovastatin by Aspergillus terreus: use of response surface methodology , 2004 .
[67] R. Couch,et al. Rational elimination of Aspergillus terreus sulochrin production. , 2004, Journal of biotechnology.
[68] Y. Chisti,et al. Production of lovastatin by Aspergillus terreus: effects of the C:N ratio and the principal nutrients on growth and metabolite production , 2003 .
[69] J. Tobert,et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors , 2003, Nature Reviews Drug Discovery.
[70] E. Moriguchi,et al. National alert campaign about increased cholesterol: determination of cholesterol levels in 81,262 Brazilians. , 2003, Arquivos brasileiros de cardiologia.
[71] Long-Shan T. Lai,et al. The influence of medium design on lovastatin production and pellet formation with a high-producing mutant of Aspergillus terreus in submerged cultures , 2003 .
[72] Shrikumar Suryanarayan,et al. Current industrial practice in solid state fermentations for secondary metabolite production: the Biocon India experience , 2003 .
[73] J. Alarcón,et al. Production and Purification of Statins from Pleurotus ostreatus (Basidiomycetes) Strains , 2003, Zeitschrift fur Naturforschung. C, Journal of biosciences.
[74] Manor Askenazi,et al. Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains , 2003, Nature Biotechnology.
[75] Saeid,et al. SCREENING OF LOVASTATIN PRODUCTION BY FILAMENTOUS FUNGI , 2003 .
[76] M. Manzoni,et al. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs , 2002, Applied Microbiology and Biotechnology.
[77] P. Niederberger,et al. Lovastatin Biosynthesis by Aspergillus terreus in a Chemically Defined Medium , 2001, Applied and Environmental Microbiology.
[78] J. Deisenhofer,et al. Structural Mechanism for Statin Inhibition of HMG-CoA Reductase , 2001, Science.
[79] C. Kuo,et al. Influence of Increased Dissolved Oxygen Tensions by Agitation on Secondary Metabolite Production by a Mutant of Aspergillus Terreus in a 5L Fermentor , 2001 .
[80] C. Richard Hutchinson,et al. Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases , 2000, Antonie van Leeuwenhoek.
[81] A. Sadhukhan,et al. A rapid technique for screening of lovastatin-producing strains of Aspergillus terreus by agar plug and Neurospora crassa bioassay. , 2000, Journal of microbiological methods.
[82] S. Parsons,et al. High purity, high yield procedure for butyrolactone I production from Aspergillus terreus , 1999 .
[83] C. R. Davis,et al. Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. , 1999, Chemistry & biology.
[84] J. Vederas,et al. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. , 1999, Science.
[85] M. Manzoni,et al. Production of statins by filamentous fungi , 1999, Biotechnology Letters.
[86] M. Manzoni,et al. Production and purification of statins from Aspergillus terreus strains , 1998 .
[87] M. Berovič,et al. Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process , 1997, Biotechnology Letters.
[88] Jenö Fekete,et al. Monitoring of selected metabolites and biotransformation products from fermentation broths by high-performance liquid chromatography , 1997 .
[89] M. Benčina,et al. High-performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths☆ , 1995 .
[90] V. Křen,et al. Determination of Lovastatin (mevinolin) and mevinolinic acid in fermentation liquids , 1993 .
[91] V. Vinci,et al. Mutants of a lovastatin-hyperproducingAspergillus terreus deficient in the production of sulochrin , 1991, Journal of Industrial Microbiology.
[92] A. Endo,et al. Biosynthesis of monacolins: conversion of monacolin J to monacolin K (mevinolin). , 1990, The Journal of antibiotics.
[93] A. Endo,et al. Biosynthesis of monacolins: conversion of monacolin L to monacolin J by a monooxygenase of Monascus ruber. , 1989, The Journal of antibiotics.
[94] K. Hasumi,et al. Productivity of Monacolin K(Mevinolin)in the Genous Monascus. , 1986 .
[95] Richard N. Moore,et al. Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus. Determination of the origin of carbon, hydrogen, and oxygen atoms by carbon-13 NMR and mass spectrometry , 1985 .
[96] J. Yudkovitz,et al. Mevinolinic acid biosynthesis by Aspergillus terreus and its relationship to fatty acid biosynthesis , 1985, Journal of bacteriology.
[97] A. Endo,et al. Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase. , 1985, Journal of medicinal chemistry.
[98] Richard N. Moore,et al. Biosynthesis of mevinolin. Spectral assignment by double-quantum coherence NMR after high carbon-13 incorporation , 1983 .
[99] R Monaghan,et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. , 1980, Proceedings of the National Academy of Sciences of the United States of America.
[100] Endo Akira,et al. Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals , 1979 .
[101] M. Brown,et al. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. , 1978, The Journal of biological chemistry.
[102] Y. Tsujita,et al. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. , 1976, The Journal of antibiotics.
[103] H. Raistrick,et al. Studies in the biochemistry of micro-organisms: The metabolic products of Aspergillus terreus Thom. Part II. Two new chlorine-containing mould metabolic products, geodin and erdin. , 1936, The Biochemical journal.
[104] Wen-long Huang,et al. Virtual screening for cholesterol absorption inhibitors. , 2014, Medicinal chemistry (Shariqah (United Arab Emirates)).
[105] C. Hollenbeak,et al. Association between statin use and lipid status in quality improvement initiatives: statin use, a potential surrogate? , 2012, Quality in primary care.
[106] M. A. El-Hameed. Optimization of Some Physical and Chemical Factors for Lovastatin Productivity by Local Strain of Aspergillus terreus , 2011 .
[107] A. El-hameed. Screening for the Production of Cholesterol Lowering Drugs (Lovastatin) by Some Fungi , 2011 .
[108] J. Barrios-González,et al. Biotechnological production and applications of statins , 2009, Applied Microbiology and Biotechnology.
[109] S. Ledakowicz,et al. The morphological and physiological evolution of Aspergillus terreus mycelium in the submerged culture and its relation to the formation of secondary metabolites , 2009 .
[110] Y. Chisti,et al. Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy , 2007 .
[111] S. Ledakowicz,et al. Supplementation of the cultivation media with B-group vitamins enhances lovastatin biosynthesis by Aspergillus terreus. , 2007, Journal of biotechnology.
[112] B. Borup,et al. Parallel capillary electrophoresis for the quantitative screening of fermentation broths containing natural products. , 2005, Metabolic engineering.
[113] T. Pan,et al. Production of the secondary metabolites γ-aminobutyric acid and monacolin K by Monascus , 2003, Journal of Industrial Microbiology and Biotechnology.
[114] C. Amodeo,et al. Campanha nacional de alerta sobre o colesterol elevado. Determinaçäo do nível de colesterol de 81.262 brasileiros , 2003 .
[115] Teilin Wang,et al. Application of oxygen vectors to Aspergillus terreus cultivation. , 2002, Journal of bioscience and bioengineering.