Nanoparticles for Detection, Imaging, and Diagnostic Applications in Animals

The conventional therapies and modalities have paved the way for the progress and advancement of comparatively finer technologies in the field of theranostics. The advents of nanotechnology have presented a much better alternative as they provide novel diagnostic and therapeutic approaches. This chapter describes the types of nanosystems available for detection, imaging, and treatment. Surface functionalization of nanomaterials makes them very flexible to use in biomedical applications and also enhances their target specificity, besides reducing the cytotoxicity which justifies their use for imaging and detection application in conventional techniques such as magnetic resonance imaging. The specificity of nanoparticles, alongside facilitating the imaging modalities, also helps in targeted treatment such as hyperthermia-based therapy. The introduction of different types of biosensor has made it easier to detect the disease at early stage and thus provide the patient an appropriate treatment timely. Therefore, this chapter puts forth the nanoparticle-based applications in detection, imaging, and diagnostics in animals.

[1]  Shaowei Chen,et al.  Surface Functionalization of Metal Nanoparticles by Conjugated Metal-Ligand Interfacial Bonds: Impacts on Intraparticle Charge Transfer. , 2016, Accounts of chemical research.

[2]  Gajendra S Shekhawat,et al.  Label-free ultra-sensitive detection of atrazine based on nanomechanics , 2008, Nanotechnology.

[3]  I. Rodríguez,et al.  Direct detection of heroin metabolites using a competitive immunoassay based on a carbon-nanotube liquid-gated field-effect transistor. , 2010, Small.

[4]  Mohammed Zourob,et al.  DNA-Based Nanobiosensors as an Emerging Platform for Detection of Disease , 2015, Sensors.

[5]  M. Berger,et al.  Extensive Distribution of Liposomes in Rodent Brains and Brain Tumors Following Convection-Enhanced Delivery , 2004, Journal of Neuro-Oncology.

[6]  Shaker A Mousa,et al.  Biosensors: the new wave in cancer diagnosis. , 2010, Nanotechnology, science and applications.

[7]  A. Caminade,et al.  A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis , 2011, Science Translational Medicine.

[8]  G. De Micheli,et al.  Aptamer-based Field-Effect Biosensor for Tenofovir Detection , 2017, Scientific Reports.

[9]  D. Demarchi,et al.  Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment , 2017, Biosensors.

[11]  Erik C. Dreaden,et al.  Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. , 2008, Cancer letters.

[12]  Sonu Gandhi,et al.  Lactoferrin conjugated iron oxide nanoparticles for targeting brain glioma cells in magnetic particle imaging. , 2015, Nanoscale.

[13]  Z. Chen,et al.  Magnetic Nanoparticle-Based Hyperthermia for Head & Neck Cancer in Mouse Models , 2012, Theranostics.

[14]  A gold nanoparticle-single-chain fragment variable antibody as an immunoprobe for rapid detection of morphine by dipstick , 2018 .

[15]  N. Hijnen,et al.  Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: an in vivo proof-of-concept study. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[16]  John B Weaver,et al.  Nanoparticles for cancer imaging: The good, the bad, and the promise. , 2013, Nano today.

[17]  Gert Storm,et al.  Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release , 2010, Pharmaceutical Research.

[18]  Sonu Gandhi,et al.  Strip-based immunochromatographic assay using specific egg yolk antibodies for rapid detection of morphine in urine samples. , 2009, Biosensors & bioelectronics.

[19]  G. Sauerbrey,et al.  Use of quartz vibration for weighing thin films on a microbalance , 1959 .

[20]  Jitendra Kawadkar,et al.  NANOBIOTECHNOLOGY: APPLICATION OF NANOTECHNOLOGY IN DIAGNOSIS, DRUG DISCOVERY AND DRUG DEVELOPMENT , 2011 .

[21]  Viney Lather,et al.  Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues , 2014, Journal of pharmacy & bioallied sciences.

[22]  Xue-Long Sun,et al.  Membrane mimetic surface functionalization of nanoparticles: methods and applications. , 2013, Advances in colloid and interface science.

[23]  H. Pandey,et al.  Liposome and Their Applications in Cancer Therapy , 2016 .

[24]  Zonghai Li,et al.  Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo. , 2008, International journal of pharmaceutics.

[25]  B. D. Malhotra,et al.  Aptamer based electrochemical sensor for detection of human lung adenocarcinoma A549 cells , 2012 .

[26]  Yi Yang,et al.  Assessing clinical prospects of silicon quantum dots: studies in mice and monkeys. , 2013, ACS nano.

[27]  Deepika Singh,et al.  Nucleic Acid Based Biosensors for Clinical Applications , 2013 .

[28]  S. Shea,et al.  Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption , 2012, Science Translational Medicine.

[29]  R. Verma,et al.  Group-selective antibodies based fluorescence immunoassay for monitoring opiate drugs , 2008, Analytical and bioanalytical chemistry.

[30]  J. Gordon,et al.  Frequency of a quartz microbalance in contact with liquid , 1985 .

[31]  V. Torchilin,et al.  Current trends in the use of liposomes for tumor targeting. , 2013, Nanomedicine.

[32]  Charles B Simone,et al.  Therapeutic hyperthermia: The old, the new, and the upcoming. , 2016, Critical reviews in oncology/hematology.

[33]  Kai Yang,et al.  Carbon materials for drug delivery & cancer therapy , 2011 .

[34]  P. Skládal,et al.  Piezoelectric immunosensor for the direct and rapid detection ofFrancisella tularensis , 2008, Folia Microbiologica.

[35]  J. West,et al.  Immunotargeted nanoshells for integrated cancer imaging and therapy. , 2005, Nano letters.

[36]  Gajendra S Shekhawat,et al.  Immunoanalytical techniques for analyzing pesticides in the environment , 2009 .

[37]  C. Suri,et al.  A Flow Injection Immunosensor for the Detection of Atrazine in Water Samples , 2011 .

[38]  Leon Hirsch,et al.  Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer , 2004, Technology in cancer research & treatment.

[39]  R. O'Kennedy,et al.  Antibodies and antibody-derived analytical biosensors , 2016, Essays in biochemistry.

[40]  Yan Li,et al.  Quantum Dots for Cancer Research: Current Status, Remaining Issues, and Future Perspectives , 2012, Cancer biology & medicine.

[41]  Subinoy Rana,et al.  Surface functionalization of nanoparticles for nanomedicine. , 2012, Chemical Society reviews.

[42]  S. K. George,et al.  Nanotherapeutics in Cancer Prevention, Diagnosis and Treatment , 2014 .

[43]  P. Skládal,et al.  Electrochemical biosensors - principles and applications , 2008 .

[44]  Jinming Gao,et al.  Multifunctional Micellar Nanomedicine for Cancer Therapy , 2009, Experimental biology and medicine.

[45]  Lamiaa M. A. Ali,et al.  Polymer-coated superparamagnetic iron oxide nanoparticles as T2 contrast agent for MRI and their uptake in liver , 2017, Future science OA.

[46]  S. Griffin Biosensors for Cancer Detection Applications , 2017 .

[47]  Sabino Veintemillas-Verdaguer,et al.  The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells , 2009, Nanotechnology.

[48]  S. Curley,et al.  Targeted hyperthermia using metal nanoparticles. , 2010, Advanced drug delivery reviews.

[49]  Richard A. Revia,et al.  Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. , 2016, Materials today.

[50]  Jagriti Narang,et al.  Ultrasensitive electrochemical immuno-sensing platform based on gold nanoparticles triggering chlorpyrifos detection in fruits and vegetables. , 2018, Biosensors & bioelectronics.

[51]  Punit Kaur,et al.  Hyperthermia using nanoparticles – Promises and pitfalls , 2016, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[52]  Adam de la Zerda,et al.  Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice. , 2010, Nano letters.

[53]  I. Tohnai,et al.  Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles , 2016, Scientific Reports.

[54]  Jochen Ringe,et al.  Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking. , 2012, Biomaterials.

[55]  D. Raucher,et al.  Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy , 2015, Molecules.

[56]  Nicole Jaffrezic-Renault,et al.  Label-free impedimetric immunosensor for sensitive detection of atrazine , 2010 .

[57]  Weiling Fu,et al.  A SPR biosensor based on signal amplification using antibody-QD conjugates for quantitative determination of multiple tumor markers , 2016, Scientific Reports.

[58]  J. Janisse,et al.  Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model , 2012, Science Translational Medicine.

[59]  James F Rusling,et al.  Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. , 2009, ACS nano.

[60]  Sakhrat Khizroev,et al.  Targeted and controlled anticancer drug delivery and release with magnetoelectric nanoparticles , 2016, Scientific Reports.

[61]  Christopher W Mount,et al.  The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. , 2010, Biomaterials.

[62]  Prince Sharma,et al.  Recent advances in immunosensor for narcotic drug detection , 2015, BioImpacts : BI.

[63]  S. Gandhi,et al.  Prospects of electrochemical immunosensors for early diagnosis of preeclampsia , 2017, American journal of reproductive immunology.

[64]  W. Lu,et al.  Annexin A5–Conjugated Polymeric Micelles for Dual SPECT and Optical Detection of Apoptosis , 2011, The Journal of Nuclear Medicine.

[65]  K. Alharbi,et al.  Role and implications of nanodiagnostics in the changing trends of clinical diagnosis. , 2014, Saudi journal of biological sciences.

[66]  M. Pohanka The Piezoelectric Biosensors: Principles and Applications, a Review , 2017 .

[67]  K. Nguyen Targeted Nanoparticles for Cancer Therapy: Promises and Challenges , 2011 .

[68]  James F Rusling,et al.  Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. , 2011, Biosensors & bioelectronics.

[69]  J. Crezee,et al.  Current state of the art of regional hyperthermia treatment planning: a review , 2015, Radiation oncology.

[70]  A. Chopra,et al.  Fluoroimmunoassay based on suppression of fluorescence self-quenching for ultra-sensitive detection of herbicide diuron. , 2010, Analytica chimica acta.

[71]  S. Nie,et al.  Nanotechnology applications in cancer. , 2007, Annual review of biomedical engineering.

[72]  Sanjiv S Gambhir,et al.  A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. , 2008, Nature nanotechnology.

[73]  Pranjal Chandra,et al.  Electrochemical Nanobiosensors for Cancer Diagnosis , 2015 .

[74]  G. Sauerbrey,et al.  The use of quarts oscillators for weighing thin layers and for microweighing , 1959 .

[75]  Angela Spanu,et al.  Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids , 2016, Sensors.

[76]  H. Arami,et al.  Detection of Cancer-Specific Proteases Using Magnetic Relaxation of Peptide-Conjugated Nanoparticles in Biological Environment. , 2016, Nano letters.

[77]  Sonu Gandhi,et al.  Femtomolar detection of 2,4-dichlorophenoxyacetic acid herbicides via competitive immunoassays using microfluidic based carbon nanotube liquid gated transistor. , 2010, Lab on a chip.

[78]  In-Kyu Park,et al.  Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer , 2013, International journal of molecular sciences.

[79]  James F. Rusling,et al.  Nanoscience-Based Electrochemical Sensors and Arrays for Detection of Cancer Biomarker Proteins , 2013 .

[80]  James R Baker,et al.  Dendrimer-based nanoparticles for cancer therapy. , 2009, Hematology. American Society of Hematology. Education Program.

[81]  S. Krishnan,et al.  Nanoparticle-mediated hyperthermia in cancer therapy. , 2011, Therapeutic delivery.

[82]  J. Vörös,et al.  Electrochemical Biosensors - Sensor Principles and Architectures , 2008 .

[83]  Jeho Park,et al.  Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications , 2015, Sensors.

[84]  L. Zhang,et al.  Nanoparticles in Medicine: Therapeutic Applications and Developments , 2008, Clinical pharmacology and therapeutics.

[85]  T Lammers,et al.  Applications of nanoparticles for diagnosis and therapy of cancer. , 2015, The British journal of radiology.

[86]  I. Rodríguez,et al.  Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes , 2009 .

[87]  G. Sauerbrey Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .