Learning to Detect Pathogenic Microorganism of Community-acquired Pneumonia

Community-acquired pneumonia (CAP) is a major death cause for children, requiring an early administration of appropriate antibiotics to cure it. To achieve this, accurate detection of pathogenic microorganism is crucial, especially for reducing the abuse of antibiotics. Conventional gold standard detection methods are mainly etiology based, incurring high cost and labor intensity. Although recently electronic health records (EHRs) become prevalent and widely used, their power for automatically determining pathogenic microorganism has not been investigated. In this paper, we formulate a new problem for automatically detecting pathogenic microorganism of CAP by considering patient biomedical features from EHRs, including time-varying body temperatures and common laboratory measurements. We further develop a Patient Attention based Recurrent Neural Network (PA-RNN) model to fuse different patient features for detection. We conduct experiments on a real dataset, demonstrating utilizing electronic health records yields promising performance and PA-RNN outperforms several alternatives.

[1]  Igor Rudan,et al.  Causes of deaths in children younger than 5 years in China in 2008 , 2010, The Lancet.

[2]  S. Y. Lee,et al.  Optical Biosensors for the Detection of Pathogenic Microorganisms. , 2016, Trends in biotechnology.

[3]  Charles Elkan,et al.  Learning to Diagnose with LSTM Recurrent Neural Networks , 2015, ICLR.

[4]  Yoshua Bengio,et al.  Neural Machine Translation by Jointly Learning to Align and Translate , 2014, ICLR.

[5]  Jimeng Sun,et al.  Using recurrent neural network models for early detection of heart failure onset , 2016, J. Am. Medical Informatics Assoc..

[6]  Insu Song,et al.  Diagnosis of pneumonia from sounds collected using low cost cell phones , 2015, 2015 International Joint Conference on Neural Networks (IJCNN).

[7]  Jürgen Schmidhuber,et al.  Long Short-Term Memory , 1997, Neural Computation.

[8]  Mara Hvistendahl,et al.  Public health. China takes aim at rampant antibiotic resistance. , 2012, Science.

[9]  Johannes Gehrke,et al.  Intelligible Models for HealthCare: Predicting Pneumonia Risk and Hospital 30-day Readmission , 2015, KDD.

[10]  Li Li,et al.  The aetiology of community associated pneumonia in children in Nanjing, China and aetiological patterns associated with age and season , 2015, BMC Public Health.

[11]  Jiaquan Xu,et al.  Deaths: preliminary data for 2011. , 2012 .

[12]  E. Cohen Use of Electronic Health Records in U.S. Hospitals , 2010 .

[13]  Thomas A. Lasko,et al.  Predicting Medications from Diagnostic Codes with Recurrent Neural Networks , 2016, ICLR.

[14]  Svetha Venkatesh,et al.  DeepCare: A Deep Dynamic Memory Model for Predictive Medicine , 2016, PAKDD.

[15]  Sheldon P Stone,et al.  Community-acquired pneumonia , 1998, The Lancet.

[16]  Liang Wang,et al.  Blood Pressure Prediction via Recurrent Models with Contextual Layer , 2017, WWW.

[17]  Sowmya R. Rao,et al.  Use of electronic health records in U.S. hospitals. , 2009, The New England journal of medicine.

[18]  R. Lodha,et al.  Antibiotics for community-acquired pneumonia in children. , 2013, The Cochrane database of systematic reviews.