Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

[1]  R. Dahlstrom,et al.  Challenges and opportunities , 2021, Foundations of a Sustainable Economy.

[2]  Xiangyin Kong,et al.  ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression , 2019, Scientific Reports.

[3]  R. Eferl,et al.  Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer , 2019, Angiogenesis.

[4]  Siwei Wang,et al.  Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy , 2019, Journal of Hematology & Oncology.

[5]  P. Robson,et al.  Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. , 2019, Cancer discovery.

[6]  Johannes L. Schönberger,et al.  SciPy 1.0: fundamental algorithms for scientific computing in Python , 2019, Nature Methods.

[7]  Yun-Gui Yang,et al.  Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma , 2019, Cell Research.

[8]  R. Hruban.  Is the Early Detection of Pancreatic Cancer Possible? It Is Good News, Bad News. , 2019, Pancreas.

[9]  V. Balachandran,et al.  Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities. , 2019, Gastroenterology.

[10]  Virginia Savova,et al.  Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. , 2019, Immunity.

[11]  M. Stepp,et al.  Desmin deficiency is not sufficient to prevent corneal fibrosis , 2019, Experimental eye research.

[12]  A. Maitra,et al.  Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution , 2019, bioRxiv.

[13]  Simon G. Coetzee,et al.  ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis , 2018, Nature Medicine.

[14]  Johannes G. Reiter,et al.  Precancerous neoplastic cells can move through the pancreatic ductal system , 2018, Nature.

[15]  A. Maitra,et al.  Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. , 2018, Gastroenterology.

[16]  D. Torigian,et al.  Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. , 2018, Gastroenterology.

[17]  P. Scheet,et al.  Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression , 2018, Clinical Cancer Research.

[18]  C. June,et al.  Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. , 2018, JCI insight.

[19]  Paul Hoffman,et al.  Integrating single-cell transcriptomic data across different conditions, technologies, and species , 2018, Nature Biotechnology.

[20]  Hongyan Chen,et al.  BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. , 2017, Gastroenterology.

[21]  Hannah A. Pliner,et al.  Reversed graph embedding resolves complex single-cell trajectories , 2017, Nature Methods.

[22]  Jingqin Luo,et al.  Tissue‐Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression , 2017, Immunity.

[23]  Hans Clevers,et al.  Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer , 2017, The Journal of experimental medicine.

[24]  Mariella G. Filbin,et al.  Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq , 2017, Science.

[25]  C. Heeschen,et al.  ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation , 2016, Oncogene.

[26]  C. Wright,et al.  Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A , 2016, Molecular and Cellular Biology.

[27]  Sisi Li,et al.  Forkhead box Q1: A key player in the pathogenesis of tumors (Review). , 2016, International journal of oncology.

[28]  Xinjian Peng,et al.  Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors , 2016, Journal of Cell Science.

[29]  T. Wang,et al.  Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression. , 2016, The Journal of clinical investigation.

[30]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[31]  R. Shivdasani,et al.  Stomach development, stem cells and disease , 2016, Development.

[32]  Marco Bruschi,et al.  Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites , 2016, Nature.

[33]  Monika S. Kowalczyk,et al.  Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells , 2015, Genome research.

[34]  Masato Tanaka,et al.  Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes , 2015, Nature Communications.

[35]  Qing-Yu He,et al.  ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization , 2015, Bioinform..

[36]  M. Smit,et al.  Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17 , 2015, The Journal of Immunology.

[37]  C. Wright,et al.  Dominant and context-specific control of endodermal organ allocation by Ptf1a , 2014, Development.

[38]  Daniel Öhlund,et al.  Fibroblast heterogeneity in the cancer wound , 2014, The Journal of experimental medicine.

[39]  Stephen A. Sastra,et al.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.

[40]  Umar Mahmood,et al.  Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. , 2014, Cancer cell.

[41]  Cole Trapnell,et al.  The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells , 2014, Nature Biotechnology.

[42]  J. Gribben,et al.  Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. , 2013, Gastroenterology.

[43]  R. Gibbs,et al.  Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor. , 2013, Gastroenterology.

[44]  Y. Kajiyama,et al.  ERC/mesothelin is expressed in human gastric cancer tissues and cell lines , 2013, Oncology reports.

[45]  Thomas R Cox,et al.  LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis. , 2013, Cancer research.

[46]  J. Liao.  Linking endothelial dysfunction with endothelial cell activation. , 2013, The Journal of clinical investigation.

[47]  K. Jensen,et al.  Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[48]  R. Hruban,et al.  Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer , 2012, Oncogene.

[49]  Carlos Cuevas,et al.  Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[50]  G. Semenza,et al.  Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.

[51]  C. Wright,et al.  Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. , 2012, Developmental biology.

[52]  J. Hald,et al.  Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia , 2012, Gut.

[53]  Hans Clevers,et al.  Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium , 2011, The Journal of cell biology.

[54]  D. Banerjee,et al.  Chemokines at the crossroads of tumor‐fibroblast interactions that promote malignancy , 2011, Journal of leukocyte biology.

[55]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[56]  M. Hebrok,et al.  KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma , 2010, Nature Reviews Cancer.

[57]  B. Nelson,et al.  Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia , 2010, Molecular Cancer.

[58]  Allan R. Jones,et al.  A robust and high-throughput Cre reporting and characterization system for the whole mouse brain , 2009, Nature Neuroscience.

[59]  David Allard,et al.  Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.

[60]  R. Shivdasani,et al.  Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. , 2008, Gastroenterology.

[61]  J. Reynolds,et al.  Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation. , 2008, Oral diseases.

[62]  J. Merchant,et al.  Prospective identification of a multilineage progenitor in murine stomach epithelium. , 2007, Gastroenterology.

[63]  S. Leach,et al.  Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. , 2007, Developmental biology.

[64]  M. Barbacid,et al.  Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. , 2007, Cancer cell.

[65]  P. Malfertheiner,et al.  Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia: differentiation of two types of gastric pit cells along the rostro-caudal axis , 2007, Cell and Tissue Research.

[66]  Michael Goggins,et al.  Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. , 2005, Cancer research.

[67]  W. Frankel,et al.  Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles , 2004, Oncogene.

[68]  E. Petricoin,et al.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.

[69]  G. Rousseau,et al.  Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2. , 2003, Gene expression patterns : GEP.

[70]  M. Washington,et al.  Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas , 2002 .

[71]  A. Oldberg,et al.  Abnormal collagen fibrils in tendons of biglycan/fibromodulin‐deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[72]  T. Jacks,et al.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.

[73]  J. Murray,et al.  Pitx2 Regulates Procollagen Lysyl Hydroxylase (Plod) Gene Expression , 2001, The Journal of cell biology.

[74]  H. S. Kim,et al.  Somatic mutations of the trefoil factor family 1 gene in gastric cancer. , 2000, Gastroenterology.

[75]  R. Hruban,et al.  Genetic progression in the pancreatic ducts. , 2000, The American journal of pathology.

[76]  P. Chambon,et al.  Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein , 1996, Science.

[77]  G. Demetri,et al.  Granulocyte colony-stimulating factor and its receptor. , 1991, Blood.

[78]  M. Elices,et al.  VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site , 1990, Cell.

[79]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[80]  J. Barkin,et al.  Stomach , 2015, The American Journal of Gastroenterology.

[81]  B. Necela,et al.  Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions. , 2015, Cancer discovery.

[82]  M. Washington,et al.  Identification and manipulation of biliary metaplasia in pancreatic tumors. , 2014, Gastroenterology.

[83]  A. Maitra,et al.  DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. , 2014, Gastroenterology.

[84]  S. Kunkel,et al.  Chemokines and innate immunity. , 2000, Reviews in immunogenetics.

[85]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[86]  E CARBONETTO,et al.  [Colon Cancer]. , 1958, El Dia medico.

[87]  H. Friess,et al.  Copyright © American Society for Investigative Pathology Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis , 2022 .