Mutations in Ig α ( CD 79 a ) result in a complete block in B-cell development

[1]  M. Conley,et al.  Mutations in btk in patients with presumed X-linked agammaglobulinemia. , 1998, American journal of human genetics.

[2]  Tetsuya Nakamura,et al.  The Igα/Igβ Heterodimer on μ-Negative ProB Cells Is Competent for Transducing Signals to Induce Early B Cell Differentiation , 1997 .

[3]  M. Neuberger,et al.  The Immunoglobulin (Ig)α and Igβ Cytoplasmic Domains Are Independently Sufficient to Signal B Cell Maturation and Activation in Transgenic Mice , 1997, The Journal of experimental medicine.

[4]  D. Campana,et al.  Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. , 1996, The New England journal of medicine.

[5]  F. Ledeist,et al.  A human non-XLA immunodeficiency disease characterized by blockage of B cell development at an early proB cell stage. , 1996, The Journal of clinical investigation.

[6]  E. Meffre,et al.  Cell surface expression of surrogate light chain (ΨL) in the absence of μ on human pro‐B cell lines and normal pro‐B cells , 1996, European journal of immunology.

[7]  K. Rajewsky.  Clonal selection and learning in the antibody system , 1996, Nature.

[8]  K. Rajewsky,et al.  Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex , 1996, Science.

[9]  A. De La Hera,et al.  A novel anti-Vpre-B antibody identifies immunoglobulin-surrogate receptors on the surface of human pro-B cells , 1996, The Journal of experimental medicine.

[10]  Michel C. Nussenzweig,et al.  Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ , 1996, Science.

[11]  M. Cooper,et al.  Fate of surrogate light chains in B lineage cells , 1996, The Journal of experimental medicine.

[12]  Heikyung Suh,et al.  The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion , 1995, The Journal of experimental medicine.

[13]  S. Burdach,et al.  Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine , 1995, The Journal of experimental medicine.

[14]  C. Ware,et al.  Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice , 1994, The Journal of experimental medicine.

[15]  F. Alt,et al.  The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice , 1994, Cell.

[16]  D. Blaise,et al.  Discrete early pro‐B and pre‐B stages in normal human bone marrow as defined by surface pseudo‐light chain expression , 1994, European journal of immunology.

[17]  M. Nussenzweig,et al.  Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta , 1993, The Journal of experimental medicine.

[18]  H. Karasuyama,et al.  A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines , 1993, The Journal of experimental medicine.

[19]  M. Reth,et al.  Differential signaling through the Ig‐α and Ig‐β components of the B cell antigen receptor , 1993 .

[20]  Ornella Parolini,et al.  Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia , 1993, Cell.

[21]  D. Bentley,et al.  The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases , 1993, Nature.

[22]  M. Cooper,et al.  Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Nussenzweig,et al.  Functional reconstitution of an immunoglobulin antigen receptor in T cells , 1992, The Journal of experimental medicine.

[24]  M. Reth,et al.  Crosslinking of the cell surface immunoglobulin (mu-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin kappa locus. , 1992, International immunology.

[25]  K. Rajewsky,et al.  A critical role of λ5 protein in B cell development , 1992, Cell.

[26]  M. Reth,et al.  The B-cell antigen receptor complex. , 1991, Immunology today.

[27]  F. Melchers,et al.  B lymphocyte lineage‐restricted expression of mb‐1, a gene with CD3‐like structural properties. , 1988, The EMBO journal.

[28]  F. Alt,et al.  Activation of V kappa gene rearrangement in pre‐B cells follows the expression of membrane‐bound immunoglobulin heavy chains. , 1987, The EMBO journal.

[29]  S. Bauer,et al.  The surrogate light chain in B-cell development. , 1993, Immunology today.

[30]  Y. Luo,et al.  Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen. , 1993, Blood.